New DNA test could spot hidden TB in chest fluid, reducing invasive procedures
NCT ID NCT06439810
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing a new laboratory method that looks for DNA fragments from tuberculosis bacteria in fluid around the lungs (pleural effusion). The goal is to see if this test can diagnose tuberculous pleurisy more accurately than current tests. Researchers will study 400 adults with new-onset pleural effusion who need a fluid sample taken. If the test works well, it could lead to quicker diagnosis, fewer invasive procedures, and earlier treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Mycobacterium tuberculosis cell-free DNA (MTB cfDNA) assay
- What this could lead to
- If successful, this could provide a faster, less invasive way to diagnose tuberculous pleurisy, helping patients start treatment sooner and avoid unnecessary procedures.
- What could go wrong
- This is an early-stage diagnostic study, not a treatment trial. The new test may not prove more accurate than existing methods, and results may vary across different populations.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chinese University of Hong Kong
RECRUITINGShatin, Hong Kong, 000, Hong Kong
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