COPD

This pilot trial tests whether tirzepatide, a once-weekly injection used for diabetes and weight loss, can improve lung function and muscle health in overweight adults with COPD. About 30 participants will receive either tirzepatide or standard care for 12 months, with tests meas…

This trial investigates whether a 7-day course of antibiotics works as well as the standard 14-day course for adults hospitalized with a sudden worsening of COPD. The study involves over 500 participants and measures clinical success at 30 days, including symptom improvement and …

This study tests a program called Snacktivity, which involves doing very short bursts of moderate exercise—like brisk walking for 2 to 5 minutes, several times a day—to see if it can improve thinking skills and the ability to manage daily health in people aged 60 and older with C…

This trial investigates whether adding an astaxanthin-based dietary supplement to a standard pulmonary rehabilitation program can improve exercise capacity in people with moderate to very severe COPD. Participants take two capsules of the supplement daily for 8 weeks while comple…

This study tests whether a dedicated clinic for COPD flare-ups can reduce the number of future attacks and improve quality of life. About 240 people who recently had a severe COPD attack will be split into two groups: one gets follow-up at the special clinic, the other gets stand…

This study tests whether frequent sauna baths can reduce or eliminate bacteria that cause stubborn lung infections in people with conditions like COPD, asthma, or bronchiectasis. Researchers will track how long participants go without needing antibiotics and whether the bacteria …

This study tests a new inhaled drug called HRS-9821 in people with moderate to severe COPD. About 90 participants will receive either the drug or a placebo for 28 days. The main goal is to see if the drug improves lung function, measured by how much air they can exhale in one sec…

This study tests a device that targets nerves in the lungs to help people with moderate to severe COPD breathe easier. About 300 participants will be randomly assigned to receive the real treatment or a sham procedure. Researchers will track symptoms, exercise ability, and flare-…

This study will test whether the drug erdosteine, added to standard COPD treatment, can reduce inflammation and oxidative stress in the body. Thirty adults with moderate-to-severe COPD will take either erdosteine or their usual inhaled therapy for 30 days. Researchers will analyz…

This study tests whether a single dose of the RSV vaccine (Arexvy) can reduce moderate-to-severe COPD flare-ups in people who have frequent attacks. Researchers will enroll 320 high-risk patients aged 50+ and follow them for one year. Half will get the vaccine plus standard care,…

This study tests an experimental drug called XKH001 in 75 people with moderate to severe COPD. The drug is given as an injection to see if it can improve lung function and reduce symptoms over 24 to 48 weeks. Participants are randomly assigned to receive either the drug or a plac…

This study tests whether a pharmacist-led mobile game can improve health in adults aged 50 and older with COPD. 126 participants will either receive usual care or use the game at home for 2 weeks with pharmacist guidance. The goal is to see if the game helps with symptoms, inhale…

This study looks at whether the inhaled drug iloprost can safely lower blood pressure in the lungs and improve exercise ability in adults with severe COPD. Fifteen participants will take iloprost 6 to 9 times daily for 12 weeks, with tests before and after treatment. There is no …

This study tests whether using a BiPAP breathing machine at home can help people with severe COPD who have high carbon dioxide levels. Forty adults will use the machine nightly for a year while continuing standard medications. Researchers will track blood gas levels, breathing sy…

This study tests a 12-week pulmonary rehabilitation program for people with stable COPD. The program includes hospital sessions (education, exercise, nutrition advice, smoking cessation) and home exercises (walking, strength training). Researchers will measure how far participant…

This study tests a 20-week program combining a low-calorie diet with exercise in 70 people who have both obesity and COPD. The goal is to see if weight loss can improve how far they can walk in 6 minutes, as well as their lung function, symptoms, and inflammation. If it works, it…

This study evaluates a portable device that measures lung function using oscillometry—a technique that sends gentle sound waves into the lungs—to diagnose chronic respiratory diseases like COPD, asthma, and bronchiectasis. Researchers will enroll about 4,000 adults across 50 cent…

This study looks at whether adding a continuous saltwater mist to warm, humidified air can make thick lung mucus easier to clear. 35 adults hospitalized with lung conditions like COPD or cystic fibrosis will receive both treatments on separate days. Researchers will measure mucus…

This study explores whether a mild electrical stimulation on the face (trigeminal nerve) can reduce the feeling of breathlessness. It first tests the technique in healthy volunteers to understand how it affects breathing control, then checks if it is feasible and helpful for peop…

This study looks at whether a pulmonary rehab program for COPD patients that meets only once a week is as good as one that meets three times a week. About 158 people with COPD will take part, doing supervised exercises plus home workouts for 8 weeks. The goal is to make rehab eas…

This study looks at whether inhaling a bronchodilator (salbutamol) at a different lung volume helps it work better in people with COPD. 30 participants will inhale the medication either from a low lung volume (as usually done) or from a higher, more relaxed volume. The goal is to…

This study compares two breathing devices—the Breather and an incentive spirometer—to see which better reduces shortness of breath, improves lung function, and boosts quality of life in people with mild-to-moderate COPD. Eighty adults aged 45 to 65 will use one of the devices and…

This study tests whether a nurse-guided breathing exercise called Pursed Lip Breathing can help people with COPD feel less anxious and have better vital signs (like heart rate and oxygen levels) right after a bronchoscopy. Sixty-four adults with COPD will be randomly assigned to …

This study tests if a gentle, non-invasive brain stimulation method can improve memory and attention in people with COPD who have thinking problems. Twenty-four adults with stable COPD and mild cognitive issues will receive either real or fake stimulation for 20 minutes a day, 5 …

This study tests a lightweight, battery-powered device called MoblO2 that automatically adjusts oxygen flow to keep blood oxygen at a healthy level during exercise. It is designed for people with COPD or interstitial lung disease who need supplemental oxygen. Over two weeks, 48 p…

This study tests whether placing a whiteboard at the bedside with key care information (nurse/doctor names, treatment times, and discharge plans) can reduce anxiety and depression in COPD patients and improve their satisfaction with nursing care. About 128 hospitalized adults wit…

This study will follow up to 840 people with heart disease or COPD who join a group rehab program. Researchers want to see how many patients take part, how often they attend, and how their test results and quality of life change. The goal is to find out what helps patients improv…

This study tests a new computer system that helps pharmacists provide better care for people with COPD, a serious lung disease. The system guides pharmacists to check symptoms, adjust medications, and create action plans. About 25 pharmacy staff and their COPD patients will use t…

This study aims to find early signs of diseases like heart disease, diabetes, and cancer by analyzing blood samples over time. Researchers will collect health data and blood from 15,000 adults aged 40-70 to create personalized health baselines using artificial intelligence. The g…

This study tests whether giving people with heart or lung conditions real-time air pollution data helps them exercise outdoors more safely. 80 participants will use a smartphone platform that tracks their walking and local air quality. The goal is to see if this approach reduces …

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will take a single blood sample from 100 adults to study immune cell changes during inflammation and infection. Participants won't receive dire…

This study tests whether a special ultrasound technique called shear wave elastography can measure how hard someone is working to breathe. Currently, doctors must insert a balloon-tube into the esophagus to measure breathing effort, which is uncomfortable. Researchers will compar…

This study will enroll 120 adults with asthma or COPD to see how changes in lung function tests (spirometry and impulse oscillometry) relate to how much their breathing improves after using a bronchodilator. Participants will take a standard reversibility test and report their sy…

This study looks at 150 adults hospitalized for a COPD flare-up to find hidden heart and kidney problems. Researchers will use a special discharge care plan and compare readmission rates to past patients. The goal is to understand how often these hidden issues occur and improve f…

This study will analyze lung tissue from 150 people with and without COPD using single-cell sequencing. The goal is to understand the molecular changes that drive the disease. Researchers hope this knowledge will point toward new ways to diagnose or treat COPD in the future.

This study looks at whether certain substances in the blood, like surfactant protein-D (SP-D), can help doctors predict how severe a COPD attack will be in hospitalized patients. Researchers will measure these markers in 75 adults admitted for a COPD flare-up and compare them to …