Simple breath change could boost COPD inhaler power

NCT ID NCT05381415

Not yet recruiting Symptom relief Sponsor: University of Milan Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether inhaling a bronchodilator (salbutamol) at a different lung volume helps it work better in people with COPD. 30 participants will inhale the medication either from a low lung volume (as usually done) or from a higher, more relaxed volume. The goal is to see if the higher volume leads to better airflow and more even drug distribution, potentially making inhalers easier to use effectively.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: salbutamol (a bronchodilator) inhaled via a spacer
What this could lead to: If it works, this could simplify how COPD patients take their inhalers, making treatment easier and possibly more effective.
What could go wrong: This is a very small, early study (30 people) that has not started yet. It only tests a single dose of one drug, so results may not apply to other medications or long-term use.

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Conditions

The condition(s) this trial relates to.

acute lung injury chronic obstructive pulmonary disease COPD, severe early onset Lung Injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COPD LUNG INJURY

Contacts and locations

Locations

L. Sacco Hospital

Milan, 20157, Italy

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