COPD

This phase 2 trial investigates the safety and tolerability of EP395, an oral capsule taken once daily for 12 weeks, in people with chronic obstructive pulmonary disease (COPD). The study includes 61 adults aged 45 and older and compares EP395 against a placebo. Researchers monit…

This study tested whether mepolizumab, an asthma drug, can reduce lung inflammation and flare-ups in people with COPD who have high levels of eosinophils (a sign of asthma-like inflammation). Thirty-one participants received mepolizumab every 4 weeks for a year and had MRI scans …

This early-stage trial tested whether EP395, an oral capsule, can reduce lung inflammation in healthy adults. All 49 participants inhaled a substance that causes temporary airway inflammation, mimicking a key feature of COPD. Researchers measured inflammation levels and collected…

This study tested whether a drug called mepolizumab, given after a severe COPD flare-up that required hospital care, could prevent future hospital stays or death. It involved 238 adults with eosinophilic COPD (a type with high levels of certain white blood cells). Participants re…

This study tested whether giving live vaccines (BCG and MMR) to people with COPD can train their immune system to produce less harmful inflammation. Sixty adults with COPD received either the vaccines or a placebo. Researchers measured changes in immune cell activity over four mo…

This study looked at whether using a HEPA air purifier at home can improve lung health in adults with a type of COPD called eosinophilic COPD. 178 people took part, with half getting real purifiers and half getting fake ones. The main goal was to see if the purifiers helped with …

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This study compared two different triple-combination inhalers (BGF and FUV) in 22 people with stable COPD. The goal was to see which one better improves small airway function. Participants used each inhaler for a period and then switched, allowing a direct comparison of their eff…

This study tested a new inhaler that combines three medicines (CHF 5993) against a two-medicine inhaler (CHF 1535) in over 3,400 people with COPD. The goal was to see if the triple combination improves lung function and reduces serious breathing attacks over 52 weeks. Participant…

This study tested a personalized approach for people with severe COPD. Doctors used a simple blood test (eosinophil count) to decide whether to reduce inhaled steroids, and some patients also received the antibiotic azithromycin. The goal was to see if this strategy could reduce …

This study tested whether inhaling a solution containing ectoin, a natural substance, can reduce inflammation in the lungs and help prevent further loss of lung function. It involved 36 postmenopausal women aged 75–80 with mild airway obstruction and signs of inflammation. Partic…

This study tested a once-daily inhaler called Trelegy Ellipta in 80 adults hospitalized for a COPD flare-up. The goal was to see if it reduces the need for extra rescue breathing treatments and shortens hospital stays. Participants took the inhaler daily along with short-term ste…

This study looked at whether adding casein protein and leucine (an amino acid) to meals could help people with COPD and healthy older adults build more muscle. Weight loss and muscle loss are common in COPD and can make the disease worse. Researchers tested different meal combina…

This study tested whether the drug vapendavir can reduce breathing problems in people with COPD who catch a rhinovirus (common cold). Fifty-two adults with COPD were given either vapendavir or a placebo after being exposed to the virus. The main goal was to see if vapendavir lowe…

This study followed over 1,300 people with moderate to severe COPD whose symptoms were not controlled by standard dual inhalers. Researchers measured how Trimbow, a triple-combination inhaler, affected their quality of life and lung function over six months. The goal was to see i…

This study tested a device that teaches people with COPD or asthma how to use their inhalers correctly. About 140 adults aged 18-85 who already use specific inhalers will be trained with either the device or standard brief instruction. The goal is to see if the device improves in…

This study tested whether sleeping with the head and trunk raised (using an adjustable bed backrest) improves sleep quality in people with chronic obstructive pulmonary disease (COPD). Twenty-four adults with severe COPD and sleep difficulties each tried the raised position and t…

This study tested whether a home-based exercise program using an exergaming (video-game exercise) system, supervised remotely by a physiotherapist, could improve physical fitness and quality of life in people with COPD. 92 participants were randomly assigned to either the exergam…

This study tested whether taking a daily arginine supplement (Bioarginine) for 6 weeks can improve breathing and daily activities in people with COPD. 153 participants were randomly assigned to receive the supplement or a placebo on top of their usual inhaled medications. The goa…

This study tested whether specific osteopathic techniques (rib rising and thoracic lymphatic pump) combined with a manual diaphragmatic release could improve breathing in 66 people with stable moderate-to-severe COPD, aged 60-75. Participants received the hands-on therapy, and re…

This study looked at whether adding balance exercises to standard lung rehab can help prevent falls in people over 80 with COPD. 21 participants were split into two groups: one did the usual rehab, the other added balance training. The goal was to see if balance improved and fall…

This study tested whether an internet-based walking program with a pedometer could help veterans with COPD who cannot attend hospital rehab become more active. 146 veterans took part, and their daily step counts were measured. The goal was to see if this approach improves physica…

This study tested two breathing techniques—Wim Hof method and box breathing—in 60 people with mild COPD. The goal was to see if these exercises could reduce anxiety and breathlessness and improve lung function. Participants practiced one of the two techniques, and researchers mea…

This study tested whether using virtual reality (VR) glasses for 30 minutes each evening could improve sleep quality, reduce anxiety, and stabilize vital signs in intensive care patients with COPD. Fifty patients were split into two groups: one received VR sessions for a week, th…

This Phase 2a study tested an inhaled drug called JKN2304 in 42 adults with moderate-to-severe COPD. Participants received either JKN2304, a placebo, or an active comparator (formoterol) for 14 days. The main goal was to check safety, and researchers also measured changes in lung…

This study followed 661 Italian adults with moderate to severe COPD who were prescribed the Trimbow inhaler. Researchers measured changes in health status using the COPD Assessment Test (CAT) and how well patients stuck to their medication over 12 months. The goal was to see if t…

This small pilot study looked at whether a 12-week tai chi program is practical and helpful for people with chronic obstructive pulmonary disease (COPD). Ten adults with COPD were randomly assigned to either tai chi or usual care. The study focused on whether tai chi could improv…

This study looked at whether playing the harmonica could help people with COPD improve their breathing muscle strength, reduce shortness of breath during activity, and boost quality of life. Fifteen people who had completed a pulmonary rehab program took part in a 12-week harmoni…

This study tested whether learning self-hypnosis can help people with severe COPD manage anxiety and shortness of breath during pulmonary rehabilitation. 133 participants took part, with some learning hypnosis techniques in two group sessions. The goal was to see if hypnosis coul…

This Phase 1 trial tested the safety and tolerability of a new drug called 9MW1911 in 48 healthy adults. The drug is being developed for asthma, COPD, and atopic dermatitis. Participants received either the drug or a placebo by IV infusion, and researchers monitored side effects …

This study tested two methods to strengthen leg muscles in 102 people with severe COPD: electrical stimulation (using pads on the skin) and stationary cycling. Both were part of a 3-4 week hospital rehab program. The goal was to see which better improves leg function and exercise…

This pilot study tested a 15-minute controlled breathing routine (REST) in 20 adults with COPD who reported high stress. Participants learned three yoga breathing techniques and practiced them twice daily for a week with remote guidance. The study aimed to see if the routine was …

This study tested a telephone-based program called EPIC, where nurse coaches guide older adults with COPD and their caregivers through sessions on managing symptoms and planning care. The goal was to see if the program is feasible and acceptable. Fifty participants were split int…

This study tested whether a breathing training device (IMT/PEP) could improve lung function and reduce breathlessness in people with severe, exacerbation-prone COPD. 61 stable patients used the device twice daily for 12 weeks alongside their usual medications. Researchers measure…

This study tested whether a home-based pulmonary rehabilitation programme could help people with COPD in areas with limited healthcare resources. 128 participants either received the 8-week home programme (exercise, education, and phone support) or standard care. Researchers meas…

This small study tested whether a painless brain stimulation technique called tDCS could reduce shortness of breath in people hospitalized with a COPD flare-up. Thirty participants received either real tDCS or a sham version, plus standard physiotherapy, over three days. Research…

This study tested whether using a hand fan for 10 minutes daily over six weeks could reduce shortness of breath, anxiety, and depression in people with COPD. Fifty-nine patients from a hospital in Turkey took part, with half using the fan and half receiving standard care. The goa…

This study tested two types of exercise programs in 36 people with COPD: one focused on breathing muscles and the other on core (abdominal and back) muscles. The goal was to see which better improves diaphragm function, breathing strength, exercise ability, and quality of life. P…

This study looked at how the nasal immune system of people with COPD reacts to a live flu vaccine (FluMist). Researchers compared those who have frequent COPD flare-ups to those who do not, to see if differences in immune response or viral replication might explain the flare-ups.…

This study looks at how exercise training affects the growth and maturation of tiny blood vessels in the leg muscles of people with COPD. Researchers will compare healthy volunteers and COPD patients doing different exercise intensities for 5 to 10 weeks. The goal is to understan…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study tested whether taking two common blood thinners (aspirin and clopidogrel) for two weeks can improve blood flow in the lungs of smokers with COPD. Fifteen current or former smokers with and without COPD participated. The goal was to see changes on a special CT scan, not…

This study looked at how a new medicine called EP395, being developed for COPD, interacts with other common drugs. It involved 37 healthy adults aged 18 to 55. The goal was to see if EP395 changes how other drugs work in the body, which helps doctors use it safely in the future.

This study looked at how one night of no sleep affects shortness of breath and exercise ability in 20 people with COPD. Participants did exercise tests after a normal night and after a sleepless night to compare. The goal was to understand if sleep loss makes breathing harder dur…

This study looked at 37 people with COPD who were having a lung-attack (sudden worsening of breathing). Researchers compared two treatment strategies: using only short-acting rescue inhalers versus adding long-acting inhalers. They used a safe, easy breathing test called oscillom…

This study tested whether a large language model (like GPT-4) could help doctors follow official treatment guidelines for COPD. 78 hospitalized COPD patients were randomly assigned to either receive standard care or have their discharge treatment reviewed by the AI. The goal was …

This study uses a special MRI technique with inhaled helium-3 gas to measure how fast air moves through the windpipe and lungs. Researchers will compare airflow in healthy volunteers and people with COPD or constrictive bronchitis. The goal is to gather real-world data to improve…

This study looked at whether doing virtual reality exercises with other people (multi-player) is more motivating than doing them alone. It included 86 participants: healthy teens, children with motor disorders, and older adults with conditions like stroke or COPD. Researchers mea…

This completed study from Fudan University looked at 200 older adults with COPD who also have sarcopenic obesity — a condition where muscle loss and excess fat occur together. Researchers used a device called InBody S10 to measure body composition and phase angles, aiming to buil…

This study tested a new way to find early signs of lung damage in people with COPD or ILD by analyzing carbon dioxide (CO2) in their breath in real time. Researchers aimed to detect changes before standard lung function tests show any problems. The study included 40 adults, inclu…

This study looked at whether a family of proteins called GPCRs, found on the surface of cells, can be used as biomarkers to diagnose or track chronic lung diseases like asthma and COPD. Researchers analyzed blood samples from 205 people (healthy volunteers and patients) to see if…

This study looked at whether short bursts of exercise (interval training) help keep oxygen levels higher in people with COPD who experience drops in oxygen during activity. Twelve patients completed both an interval and a continuous exercise session while their oxygen levels were…

This study looked at 150 adults with COPD to see if a drop in exercise ability during pulmonary rehabilitation could predict when a flare-up (exacerbation) might happen. Researchers tracked changes in physical performance and compared them to hospital visits for COPD attacks. The…

This completed study looked at whether an online tool called the COPD Optimiser could help general practitioners find ways to improve care for people with COPD. Researchers enrolled 100 patients in the Netherlands and used the tool during a regular check-up to see where treatment…

This study measured breathing patterns in 163 adults with asthma or COPD to help computers predict how much of an inhaled drug actually reaches the lungs. Researchers used these real-world breathing measurements to improve simulations of aerosol drug deposition. The goal is to ma…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can accurately count coughs in people with lung conditions like COPD, asthma, or COVID-19. Researchers compared the app's cough counts to patients' own reports and expert listening. The goal was to improve …

This study tested whether a questionnaire called VQ11 can accurately measure changes in quality of life for people with COPD who start taking a long-acting bronchodilator. Fifty-seven stable COPD patients filled out the VQ11 before and after three months of treatment. The goal wa…

This study looked at how a mix of home and on-site resistance training affects muscle loss and fatigue in people with chronic respiratory diseases like COPD, obstructive sleep apnea, or lingering COVID-19 symptoms. 72 adults aged 30-85 completed 18 exercise sessions. Researchers …

This study reviewed medical records of 59 adults with COPD to see if a standard pulmonary rehabilitation program is safe and effective for those who also have pulmonary hypertension (high blood pressure in the lungs). Researchers compared how much walking distance improved in peo…

This study looked at whether adding a mental task (like counting or word games) to standard exercise helps people with COPD improve their physical and mental abilities. 42 participants were split into two groups: one did standard pulmonary rehab, the other added cognitive tasks d…

This study tested whether a quick, non-invasive breathing test called impulse oscillometry (IOS) can track lung function during COPD exacerbations and recovery. 38 patients were tested during a flare-up and again 6-12 weeks later. The results suggest IOS can detect changes in sma…

This study looked at whether doing two 6-minute walk tests at the end of a pulmonary rehabilitation program gives a more accurate measure of exercise capacity in people with COPD. Researchers compared the distance walked in the first and second tests to see if there was a meaning…

This study tested whether showing older hospitalized patients their own activity levels on a bedside screen could encourage them to move more. 130 adults aged 60+ with conditions like COPD, heart failure, or Parkinson's wore a small sensor and saw real-time feedback on time spent…