Simple supplement could ease COPD breathlessness

NCT ID NCT05412160

Completed Symptom relief Sponsor: University of Milan Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking a daily arginine supplement (Bioarginine) for 6 weeks can improve breathing and daily activities in people with COPD. 153 participants were randomly assigned to receive the supplement or a placebo on top of their usual inhaled medications. The goal was to see if the supplement could reduce shortness of breath and improve quality of life, as measured by questionnaires and a walking test.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bioarginine (arginine supplement)
What this could lead to: If it works, this could offer a simple, daily supplement to help people with COPD breathe easier and do daily activities with less shortness of breath.
What could go wrong: This is a small, early proof-of-concept study, not a large definitive trial. The supplement may show no meaningful benefit over placebo, and results may not apply to all COPD patients.

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Conditions

The condition(s) this trial relates to.

arginase deficiency chronic obstructive pulmonary disease COPD, severe early onset Dyspnea

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARGININEMIA COPD DYSPNEA

Contacts and locations

Locations

L. Sacco Hospital

Milan, Italy, 20157, Italy

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