DYSPNEA

This study tests whether using lung and heart ultrasound helps emergency doctors give the right treatment to older adults (over 65) with sudden breathing trouble. About 504 participants will be enrolled. The goal is to see if ultrasound reduces the chance of starting a treatment …

This study tests a new way to quickly tell why someone is short of breath in the emergency room. It compares a skin sensor reading with a standard blood test to see if the difference (GapCO2) can identify fluid buildup in the lungs. About 45 adults will take part, and the goal is…

This study looks at whether emergency doctors using a lung ultrasound in ambulances can better diagnose the cause of severe shortness of breath. About 40 adults with serious breathing trouble will be included. The goal is to see if the ultrasound helps doctors choose the right tr…

This study looks at whether a quick ultrasound of a large vein (the inferior vena cava) can help emergency doctors figure out why a patient is having sudden trouble breathing. The goal is to tell apart fluid in the lungs from heart problems versus other causes. Researchers will e…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for six months, and…

This study tests a device called the Lung Master to see if it can help people with breathing problems like COPD or asthma increase their lung capacity. Twenty adults (ages 19-35 or over 65) will use the device daily at home for a month and have their lung function measured before…

This study tests whether starting a structured exercise and education program soon after a hospital stay for a pulmonary embolism (a blood clot in the lungs) can improve quality of life and reduce long-term symptoms like shortness of breath. About 160 high-risk adults will be ran…

This study tests whether using a hand fan can prevent or reduce shortness of breath caused by the heart drug ticagrelor. Researchers will enroll 110 adults with acute coronary syndrome who are starting ticagrelor for the first time. Participants will receive fan therapy, and the …

This study tests a personalized treatment plan called SPOT-ON that combines oxygen therapy with other supportive care to reduce shortness of breath in cancer patients. About 150 adults with cancer who are hospitalized and have significant breathlessness will take part. The goal i…

This study tests whether breathing exercises using a small handheld device can strengthen breathing muscles and reduce shortness of breath in women receiving chemotherapy for early-stage breast cancer. About 58 participants will use the device daily and be monitored for changes i…

This study tests whether inhaling menthol can quickly reduce shortness of breath in healthy adults and people with COPD. Researchers will measure brain activity and breathing to understand how menthol works. 120 participants will compare menthol to a strawberry scent during breat…

This study looks at why people feel short of breath. Researchers will use a special breathing test called oscillometry to measure airway resistance and see if it relates to exercise test results. About 50 adults who are already scheduled for a cardiopulmonary exercise test will t…

This study uses a special MRI that tracks a harmless gas (129Xe) to see how well the lungs and heart exchange oxygen. Researchers will scan healthy people and those with lung disease, anemia, or blood clots to understand how these conditions affect breathing. The goal is to devel…

This study looks at why people with myasthenia gravis (MG) feel short of breath, even during rest or sleep. Researchers will use breathing tests, sleep studies, and questionnaires in 50 adults with MG to find the causes. The goal is to improve comfort, quality of life, and preven…

This study looks at how well the diaphragm works in 800 people with lung diseases like asthma, COPD, fibrosis, and pulmonary hypertension. Researchers want to see if diaphragm problems are linked to shortness of breath. Participants will do walking and sitting tests to measure br…