Protein power: new study tests Muscle-Building meals for COPD patients

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria COPD subjects: * Ability to walk, sit down and stand up independently * Age 45 years or older * Ability to lie in supine or elevated position for 5.5 hours * Diagnosis of moderate to very severe chronic airflow limitation and compliant to the following criteria: Forced Expiratory Volume(FEV1)/Forced Vital Capacity (FVC) \< 0.70 and FEV1 \< 70% of reference FEV1 * Clinically stable condition and not suffering from a respiratory tract infection or exacerbation of their disease (defined as a combination of increased cough, sputum purulence, shortness of breath, systemic symptoms such as fever, and a decrease in FEV1 \> 10% compared with values when clinically stable in the preceding year) at least 4 weeks prior to the first test day * Shortness of breath on exertion * Willingness and ability to comply with the protocol, including: * Adhering to fasting state from 10 pm ± 2h onwards the day prior to each study visit Inclusion criteria healthy control subjects: * Healthy male or female according to the investigator's or appointed staff's judgment * Ability to walk, sit down and stand up independently * Age 45 years or older * Ability to lay in supine or elevated position for 5.5 hours * No diagnosis of chronic airflow limitation and compliant to the following criteria: FEV1/FVC \> 0.70 and FEV1 ≥ 80% of reference FEV1 * Willingness and ability to comply with the protocol, including: * Adhering to fasting state from 10 pm ± 2h onwards the day prior to each study visit Exclusion Criteria all subjects: * Any condition that may interfere with the definition 'healthy subject' according to the investigator's judgment (for healthy control group only) * Established diagnosis of malignancy * Established diagnosis of Insulin Dependent Diabetes Mellitus * History of untreated metabolic diseases including hepatic or renal disorder * Presence of acute illness or metabolically unstable chronic illness * Recent myocardial infarction (less than 1 year) * Any other condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient * BMI of \< 18.5 or ≥ 35 kg/m2 * Dietary or lifestyle characteristics: * Use of protein or amino acid containing nutritional supplements within 5 days of first test day * Current alcohol or drug abuse * Indications related to interaction with study products: * Known allergy to milk or milk products * Use of long-term oral corticosteroids or short course of oral corticosteroids 4 weeks preceding first test day * Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements * (Possible) pregnancy