Helium-3 MRI reveals hidden airflow secrets in lungs

NCT ID NCT02154568

Completed Knowledge-focused Sponsor: University of Virginia Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study uses a special MRI technique with inhaled helium-3 gas to measure how fast air moves through the windpipe and lungs. Researchers will compare airflow in healthy volunteers and people with COPD or constrictive bronchitis. The goal is to gather real-world data to improve computer models that predict breathing problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyperpolarized helium-3 gas
What this could lead to: If successful, this could help doctors better understand and predict airflow problems in lung diseases like COPD, potentially improving diagnosis and treatment planning.
What could go wrong: This is a small, early-stage study focused on measuring airflow, not testing a treatment. The results may not directly lead to new therapies or apply to all patients with lung disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bronchiolitis obliterans syndrome chronic obstructive pulmonary disease COPD, severe early onset

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONSTRICTIVE BRONCHITIS COPD HEALTHY

Contacts and locations

Locations

Snyder Translation Fontaine Research Center 480 Ray C. Hunt Drive

Charlottesville, Virginia, 22908, United States
University of Virginia Health System

Charlottesville, Virginia, 22908, United States

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