Scientists hunt for clues to prevent deadly transfusion reaction in ICU

NCT ID NCT06444750

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 28 times

Summary

This study aims to find biological markers (biomarkers) in the blood that can help doctors quickly identify a rare but serious lung injury called TRALI, which can occur after a blood transfusion in intensive care patients. Researchers will compare blood samples from 210 ICU patients with and without lung injury, both before and after transfusion, as well as from healthy volunteers. The goal is to better understand what causes TRALI and to develop a diagnostic test that could make transfusions safer.

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Conditions

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