Which Pre-Surgery combo works best for HER2+ breast cancer? new trial aims to find out

NCT ID NCT07220135

Recruiting now Disease control Sponsor: University of Kansas Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing two standard chemotherapy combinations given before surgery for people with HER2-positive early breast cancer. One group gets docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP); the other gets the same without carboplatin (THP). The main goal is to see which regimen leads to a higher rate of complete tumor disappearance (pathologic complete response). About 100 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Docetaxel, Carboplatin, Trastuzumab, Pertuzumab
What this could lead to: If it works, this could help doctors choose the most effective pre-surgery drug combination for HER2-positive breast cancer, potentially improving outcomes.
What could go wrong: This is a small, early-phase study (100 participants) comparing already standard treatments, so it may not lead to a new approach. Side effects from chemotherapy can be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm HER2 positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

KUCC - Briarcliff
RECRUITING

Westwood, Kansas, 66205, United States
KUCC - Indian Creek
RECRUITING

Overland Park, Kansas, 66211, United States
KUCC - Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States
KUCC - Olathe
RECRUITING

Westwood, Kansas, 66205, United States
KUCC - Overland Park
RECRUITING

Overland Park, Kansas, 66215, United States
The University of Kansas Cancer Center (KUCC)
RECRUITING

Fairway, Kansas, 66205, United States
The University of Kansas Cancer Center - North
RECRUITING

Kansas City, Missouri, 64154, United States
The University of Kansas Cancer Center - Westwood
RECRUITING

Kansas City, Kansas, 66205, United States

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