Can new E-Cigs and a pill help dual users kick cigarettes for good?

NCT ID NCT05703672

Recruiting now Disease control Sponsor: University of Kansas Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a 4th-generation nicotine salt e-cigarette, combined with the drug varenicline, can help people who both smoke and vape reduce their exposure to harmful chemicals and quit regular cigarettes. Researchers will enroll 500 adults who smoke at least 5 cigarettes daily and are interested in switching to e-cigarettes. The goal is to see if this approach lowers cancer-causing toxins and leads to long-term cigarette abstinence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nicotine salt pod-based e-cigarette and varenicline
What this could lead to: If successful, this could provide a safer alternative for smokers who can't quit, reducing toxic exposure and helping them stop combustible cigarettes.
What could go wrong: This is a Phase 3 trial, but results may not apply to all smokers. Varenicline can cause side effects like nausea, and e-cigarettes still carry health risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Smoking Reduction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING REDUCTION

Contacts and locations

Locations

Swope Health Central
RECRUITING

Kansas City, Missouri, 64130, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Missouri, 64130, United States

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