Can new E-Cigs and a pill help dual users kick cigarettes for good?
NCT ID NCT05703672
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a 4th-generation nicotine salt e-cigarette, combined with the drug varenicline, can help people who both smoke and vape reduce their exposure to harmful chemicals and quit regular cigarettes. Researchers will enroll 500 adults who smoke at least 5 cigarettes daily and are interested in switching to e-cigarettes. The goal is to see if this approach lowers cancer-causing toxins and leads to long-term cigarette abstinence.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nicotine salt pod-based e-cigarette and varenicline
What this could lead to
If successful, this could provide a safer alternative for smokers who can't quit, reducing toxic exposure and helping them stop combustible cigarettes.
What could go wrong
This is a Phase 3 trial, but results may not apply to all smokers. Varenicline can cause side effects like nausea, and e-cigarettes still carry health risks.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Swope Health Central
RECRUITINGKansas City, Missouri, 64130, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Medical Center
RECRUITINGKansas City, Missouri, 64130, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••