University Of Kansas Medical Center

This phase 3 trial tests sirolimus, a drug used in organ transplants, to see if it can slow or stop muscle decline in people with inclusion body myositis (IBM), a rare muscle disease. About 140 adults aged 45 and older who can walk at least 200 meters are taking part. The study m…

This study tests a drug called sacituzumab govitecan in 15 people with advanced bile duct cancer that has spread or come back. The drug works like a smart bomb, attaching to a protein on cancer cells and delivering a toxic payload to kill them. The main goal is to see how many pa…

This study compares two approaches to help rural adults with obesity lose weight. One group meets one-on-one with their doctor every three months. The other joins a group lifestyle program on Zoom and has team meetings with their doctor and a coach. Researchers will see which met…

This early-stage trial tests two drugs, alpelisib and sacituzumab govitecan, together in people with advanced HER2-negative breast cancer that has spread or come back. The main goal is to find the safest dose and see how the body handles the drugs. 18 adults are taking part in th…

This study aimed to see if the drug rituximab could help people with a nerve condition called CIDP stop their current medications and stay in remission. Researchers planned to treat three groups of 16 patients each. However, the study was withdrawn before any participants were en…

This study looks at whether the number of immune cells in and around a triple-negative breast cancer tumor can predict how well the tumor shrinks with chemotherapy and immunotherapy given before surgery. About 139 women with early-stage triple-negative breast cancer will receive …

This study tests whether combining two drugs, regorafenib and durvalumab, can help people with advanced bile duct cancer that has stopped responding to chemotherapy. About 40 participants will receive the combination to see if it slows tumor growth and how safe it is. The goal is…

This study looks at whether tirzepatide, a drug used for weight loss, can change certain markers in the blood and breast tissue that are linked to breast cancer risk. The study includes 20 women with obesity who also have other breast cancer risk factors. Researchers will measure…

This study tests whether a combination of bazedoxifene and conjugated estrogens can lower breast cancer risk in women going through menopause who have hot flashes. About 120 women at higher risk for breast cancer will take the drug for 6 months or be placed on a waiting list. Res…

This study explores whether regular heat therapy (like using a sauna) can improve how the body and brain handle sugar in healthy older adults at risk for Alzheimer's. Researchers will measure blood sugar control and brain energy use in 60 volunteers aged 65 and older. The goal is…

This study tests whether adding a mild electrical stimulation device (NMES) to standard physical therapy helps people regain muscle strength more quickly after ACL knee surgery. Researchers will compare muscle size and function between the operated and non-operated legs in 25 par…

This study tests an online training program for nursing home staff to improve how they talk with residents who have Alzheimer's or other dementias. The goal is to reduce challenging behaviors like agitation or refusal of care. Over 5,000 staff members from nursing homes across th…

This study compares two treatments for chronic low back pain caused by facet joints: standard radiofrequency ablation (RFA), which burns pain-signaling nerves, and a newer therapy called iovera°, which freezes those nerves temporarily without causing permanent damage. The goal is…

This study looks at whether giving nutrition through a feeding tube for only 12 hours a day is safe and works well for critically ill adults in the ICU. Researchers will compare this approach to the standard 24-hour feeding method. The goal is to see if the shorter schedule affec…

This study planned to compare removing a urinary catheter early versus later after minimally invasive lower back surgery. The goal was to see how timing affects how soon patients can walk. The study was withdrawn before enrolling any participants, so no results are available.

This study looks at whether drinking a special carbohydrate drink just before major urologic surgery can improve recovery and blood sugar control. About 30 adults without diabetes will be randomly assigned to get either a specialized sports drink or a standard one. Researchers wi…

This study looks at how different exercise programs affect thinking skills and brain structure in healthy adults aged 65 to 80. Researchers will measure changes in memory, attention, and brain volume over 12 months. The goal is to understand which types of exercise best support b…

This study looks at how blood pressure changes affect chronic pain in people who already have a spinal cord stimulator. About 36 adults with chronic low back pain and high blood pressure will take a standard blood pressure drug for 2 weeks and a placebo for 2 weeks. Researchers w…

This study is not testing a new treatment. Instead, it aims to make future drug trials for facioscapulohumeral muscular dystrophy (FSHD) faster and more effective. Researchers are testing new ways to measure muscle function and refining who should be included in trials. 324 adult…

This study planned to bring together teens aged 13-18 with insomnia to help design and test a new version of a mobile app called Firefly. The app was meant to teach healthy sleep habits using a type of therapy that works well for insomnia. However, the study was withdrawn before …

This study looks at how to help rural primary care doctors give better follow-up care to cancer survivors. It involves 16 clinics in Kansas and focuses on making sure survivors get recommended check-ups and screenings. The goal is to find practical strategies that improve care wi…

This small study looks at why some people on statins don't get the full benefits of exercise. Five overweight or obese adults taking high-dose atorvastatin will do supervised exercise for 6 weeks. Researchers will measure changes in fitness and link them to each person's genetic …

This study tests a web-based system called CATSystem that helps doctors follow guidelines for cervical cancer screening and treatment. About 6600 women at 10 Kenyan hospitals will take part. The goal is to see if the tool increases the number of women who get proper care after a …