University Of Kansas Medical Center

This study tests a virtual clinic where pharmacists monitor blood pressure, adjust medications, and provide telehealth support to older adults (65+) with high blood pressure. The goal is to see if better blood pressure control can also help prevent cognitive decline. About 1,000 …

This early-phase trial investigates whether itraconazole, a common antifungal medication, can reduce the risk of cancer in people with high-risk Barrett's esophagus who have already undergone endoscopic ablation. Barrett's esophagus often returns after treatment, increasing the c…

This early-stage trial tests two drugs, alpelisib and sacituzumab govitecan, together in people with advanced HER2-negative breast cancer that has spread or come back. The main goal is to find the safest dose and check for side effects. About 18 adults are taking part in this stu…

This phase 2 trial tests whether the number of immune cells in and around a triple-negative breast cancer tumor can help doctors personalize chemotherapy and immunotherapy. About 139 women with early-stage triple-negative breast cancer will receive standard chemotherapy drugs plu…

This study tests whether regular warm-water baths can improve blood sugar control and brain energy use in healthy adults aged 65 and older who are at risk for Alzheimer's disease. Over 10 weeks, 60 participants will soak in warm water three times a week. Researchers will measure …

This study tests whether a parent-only weight loss program followed by a family healthy lifestyles program works better than the family program alone. It involves 480 rural families with a child aged 6-11 who is overweight and a parent with a BMI between 25 and 50. The goal is to…

This study tests a web-based tool called the Cancer Tracking System (CATSystem) that sends automated texts and alerts to help women in Kenya get timely cervical cancer screening and follow-up care. About 6,600 women across 10 hospitals will take part, with half the hospitals usin…

This phase II trial tests a drug called sacituzumab govitecan in 15 people with advanced bile duct cancer that has spread or returned after treatment. The drug works like a smart bomb, attaching to a protein on cancer cells and delivering a toxic payload to kill them. Researchers…

This study tests whether combining two drugs—regorafenib (a targeted therapy) and durvalumab (an immunotherapy)—can help people with advanced biliary tract cancer that has stopped responding to chemotherapy. About 40 participants will receive both drugs to see if the combination …

This phase 3 trial tests whether sirolimus, a drug used in organ transplants, can slow disease progression in people with inclusion body myositis (IBM), a rare muscle-weakening condition. The study involves 140 adults aged 45 and older who can walk at least 200 meters. Over 84 we…

This study planned to test the drug rituximab in people with chronic inflammatory demyelinating polyneuropathy (CIDP), a nerve condition that causes weakness and numbness. The goal was to see if rituximab could help certain patients stop their current treatments and achieve long-…

This study will test a telehealth group prenatal care program called Centering HER in 72 low-income, predominantly Black pregnant women in Kansas who are at moderate or high risk for preeclampsia. Participants will receive routine care plus seven doula-led virtual group sessions,…

This phase 2 trial tests whether a daily pill combining bazedoxifene and conjugated estrogens can reduce breast cancer risk in 120 women aged 45-64 who have menopausal hot flashes and are at increased risk for breast cancer. Participants take the drug for 6 months or join a waitl…

This study tests whether combining walking on a treadmill with virtual reality challenges can improve both movement and thinking in older adults with motoric cognitive risk syndrome (MCR). Ten participants will do 18 sessions over six weeks, either with VR or standard treadmill t…

This study tests whether daily exposure to different scents can retrain the sense of smell in 250 adults with smell disorders, including those from traumatic brain injury. Participants will use scented inhaler sticks at home and take smell tests before and after 12 weeks. The goa…

This pilot study is testing whether taking 24 grams of whey protein daily for three months can improve brain antioxidant levels, physical function, and thinking skills in pre-frail adults aged 65 to 85. Twenty participants will be randomly assigned to receive either whey protein …

This study looks at whether drinking a special carbohydrate drink before major urologic surgery can help control blood sugar and improve recovery. Thirty adults without diabetes will be randomly assigned to get either the special drink or a standard sports drink. Researchers will…

This study tests whether a neuromuscular electrical stimulation (NMES) device, used alongside standard physical therapy, can help people regain muscle strength more quickly after ACL reconstruction surgery. Twenty-five participants aged 15 to 50 will use the Zynex NexWave device …

This study compares two treatments for chronic low back pain caused by facet joints: standard radiofrequency ablation (RFA), which burns pain nerves, and a newer freezing method called iovera°. Both aim to block pain signals temporarily. About 30 adults with long-term back pain w…

This study compares two approaches to help rural adults with obesity lose weight. One method involves quarterly one-on-one visits with a primary care doctor. The other adds a group lifestyle program over Zoom plus quarterly team meetings with the doctor and a lifestyle coach. Res…

This study tests whether wearable sensors worn on the wrist and as a pendant can accurately track changes in arm and leg function in people with inclusion body myositis (IBM), a rare muscle disease that causes progressive weakness. Researchers aim to see if these sensors can prov…

This study tests new ways to help rural primary care clinics provide better follow-up care for cancer survivors. Researchers will give clinics telementoring, quality improvement coaching, and an obesity management toolkit. The goal is to see if these tools help clinics follow nat…

This study looks at whether taking CT scans of the lower back while standing up gives doctors more useful information than the usual lying-down scans. About 20 adults who are already scheduled for a standard CT scan will also get a standing scan. The goal is to see if the standin…

This study collects blood samples and medical information from 201 adults diagnosed with COVID-19. The goal is to create a resource that researchers can use to study the virus and improve understanding of the disease. Participants provide samples and allow their health data to be…

This study is creating a biobank of blood samples and health data from 100 people who have recovered from COVID-19. Researchers will use this information to better understand recovery and long-term effects. No new treatments are being tested; the goal is to provide resources for …

This study aimed to see if singing-based exercises could help older adults with swallowing problems (dysphagia) as much as traditional speech therapy exercises. Researchers planned to measure muscle activity and brain responses during both types of exercises. However, the study w…

This study compares a 12-hour feeding schedule to the usual 24-hour schedule in 20 critically ill adults in the ICU. Researchers want to see if the shorter schedule is safe and works well, looking at feeding tolerance, blood sugar control, and sleep. The goal is to gather knowled…

This study planned to work with teens to improve a mobile app called Firefly, which uses cognitive behavioral therapy to help with insomnia. The goal was to make the app more engaging for teenagers. However, the study was withdrawn before any participants were enrolled, so no res…

This study involves 324 adults with facioscapulohumeral muscular dystrophy (FSHD) across 14 international sites. Researchers are testing two new measurement tools—a functional test called FSHD-COM and a muscle-impedance device—to better track disease progression. The goal is to i…

This study tests a program called the Sexual Health Empowerment (SHE) Project for women who are about to leave jail. The goal is to improve their understanding of cervical cancer, breast cancer, contraception, and sexually transmitted diseases. About 279 women will take part, and…

This study looks at whether genetic differences change how well exercise works for people taking statins. Five overweight or obese adults on high-dose atorvastatin will do supervised exercise for 6 weeks. Researchers will measure fitness changes and link them to each person's gen…

This study was designed to compare removing a urinary catheter early versus later after minimally invasive lumbar spine surgery. The goal was to see which approach helps patients get up and walk sooner. However, the trial was withdrawn before enrolling any participants, so no res…

This early-phase study looks at whether a common blood pressure drug, hydrochlorothiazide, can affect chronic pain in people who already have a spinal cord stimulator implant. About 36 adults with chronic low back pain and high blood pressure will take the drug or a placebo for t…