Blood pressure drug may offer clues to chronic pain relief
NCT ID NCT04676399
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-phase study looks at whether a common blood pressure drug, hydrochlorothiazide, can affect chronic pain in people who already have a spinal cord stimulator implant. About 36 adults with chronic low back pain and high blood pressure will take the drug or a placebo for two weeks each, and researchers will track changes in pain and blood pressure. The goal is not to test a new treatment, but to better understand the link between blood pressure and pain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hydrochlorothiazide 12.5mg
What this could lead to
If it works, this could point toward a better understanding of how blood pressure influences chronic pain, potentially leading to improved pain management strategies.
What could go wrong
This is a very small, early-phase study with only 36 participants. It is not testing a new treatment, just exploring a possible link, so results may not lead to any direct benefit.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The Marc A. Asher Comprehensive Spine Center at the Kansas University Medical Center
Kansas City, Kansas, 66160, United States