Blood pressure drug may offer clues to chronic pain relief
NCT ID NCT04676399
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-phase study looks at whether a common blood pressure drug, hydrochlorothiazide, can affect chronic pain in people who already have a spinal cord stimulator implant. About 36 adults with chronic low back pain and high blood pressure will take the drug or a placebo for two weeks each, and researchers will track changes in pain and blood pressure. The goal is not to test a new treatment, but to better understand the link between blood pressure and pain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Hydrochlorothiazide 12.5mg
- What this could lead to
- If it works, this could point toward a better understanding of how blood pressure influences chronic pain, potentially leading to improved pain management strategies.
- What could go wrong
- This is a very small, early-phase study with only 36 participants. It is not testing a new treatment, just exploring a possible link, so results may not lead to any direct benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Marc A. Asher Comprehensive Spine Center at the Kansas University Medical Center
Kansas City, Kansas, 66160, United States
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