Pancreatitis

This study tested two anti-inflammatory drugs (etanercept and alpha-1 antitrypsin) in 43 adults with severe chronic pancreatitis who had their pancreas removed and their insulin-making cells (islets) transplanted into the liver. The goal was to see if these drugs could protect th…

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study tested an experimental drug called CM4620-IE in 21 people with severe pancreatitis that caused body-wide inflammation (SIRS). The goal was to see if the drug is safe and to find the best dose for future studies. Participants received the drug plus standard care or stan…

This study looked at whether using low-acid contrast media (dye) during ERCP can lower the chance of developing pancreatitis afterward. Researchers reviewed records of nearly 4,000 patients from five hospitals. They compared patients who received low-acid contrast media to those …

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study compared robotic-assisted pancreatic surgery to the standard open approach for people with pancreatic and related tumors. Researchers wanted to see if robotic surgery could help patients recover faster after the operation. A total of 268 patients took part across multi…

This study tested a drug called Auxora in 216 people hospitalized with acute pancreatitis and systemic inflammatory response syndrome (SIRS), a serious body-wide inflammation. Participants received either Auxora or a placebo daily for three days. The main goal was to see if Auxor…

This study looked at 50 adults with infected, walled-off dead tissue in the pancreas from severe pancreatitis. Researchers compared doing endoscopic removal right away versus waiting until needed. The goal was to see which approach leads to complete recovery and fewer complicatio…

This study tested whether injecting epinephrine around the bile duct opening, combined with a standard rectal anti-inflammatory drug, could reduce pancreatitis after ERCP—a common procedure to treat bile duct blockages. Over 500 adults with a first-time ERCP took part. The goal w…

This study tested two types of endoscopes used in ERCP, a procedure to treat bile duct and pancreas problems. One scope had a single-use plastic cover on its tip, while the other was a standard reusable scope. Researchers compared how well each worked and how often complications …

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study looked at new markers in blood and urine to detect and predict the severity of drug-associated acute pancreatitis in adults. Researchers compared these markers in 175 patients with drug-induced pancreatitis, other pancreatic diseases, and healthy volunteers. The goal i…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This study tested whether giving rectal indomethacin (an anti-inflammatory drug) along with extra fluids before an ERCP procedure could prevent pancreatitis, a painful complication. The trial included 60 patients who needed ERCP. The goal was to see if this simple, low-cost appro…

This study tested whether taking oral N-Acetyl cysteine before an ERCP procedure could prevent pancreatitis as well as the standard treatment, rectal diclofenac. Forty-six adults at risk for pancreatitis after ERCP received one of the two drugs. The goal was to see which drug bet…

This study looked at 192 children having an ERCP procedure to see which drug—rectal indomethacin or IV ketorolac—better prevents post-ERCP pancreatitis. Both are anti-inflammatory medicines given before the procedure. The goal is to find the most effective option for kids.

This study looked at whether giving more IV fluids (aggressive hydration) during an ERCP procedure can prevent pancreatitis, a common complication. 126 adults having their first ERCP were randomly assigned to receive either standard or extra fluids. The goal was to see if extra f…

This study tested whether rinsing the duodenal papilla with cold (3°C) sterile saline right after an ERCP procedure can lower the risk of post-ERCP pancreatitis. 900 adults in Colombia were randomly assigned to receive the cold saline rinse or standard care. The main goal was to …

This study tested whether a procedure called ERCP with sphincterotomy can lower the risk of repeat pancreatitis attacks in people with pancreas divisum, a condition where the pancreas ducts don't join normally. 181 adults who had at least two pancreatitis episodes were randomly a…

This study compared two devices used during a procedure called ERCP to remove stones from the pancreatic duct in people with chronic pancreatitis. One group used a basket first, the other a balloon first. The goal was to see which tool cleared more stones. A total of 104 adults w…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether a web-based self-management program is feasible and acceptable for people with chronic pancreatitis who have ongoing abdominal pain. Thirty-one participants were given access to a tailored website with pain management modules over 12 weeks. The goal was …

This study tested a web-based program to help children aged 10-19 with chronic or recurring pancreatitis manage their abdominal pain. The program teaches cognitive behavioral skills to reduce pain and improve quality of life. 90 participants were enrolled, and the study measured …

This study tested a non-invasive device that stimulates a nerve in the ear (taVNS) to see if it can calm inflammation and improve gut function in people with acute pancreatitis. Sixty adults with early-stage pancreatitis received either the real stimulation or a sham device. The …

This study tested a small, needle-free device that sends mild electrical pulses to specific points on the skin to relieve abdominal pain in people with chronic pancreatitis. 42 adults with long-term pancreas pain used the device at home for several weeks. The goal was to see if t…

This small pilot study tested a safe, non-invasive device that uses mild electrical pulses on the skin to help reduce belly pain in people with chronic pancreatitis. The goal was to see if patients would use the device at home and if it could be a drug-free option for pain. The s…

This study looked at 220 adults with chronic pancreatitis and large pancreatic stones to find the best time to perform an endoscopic procedure after shock wave lithotripsy (ESWL). The goal was to improve stone clearance and reduce complications. Results help doctors plan treatmen…

This study tested whether using forceps to help guide a tube into the bile duct during an ERCP procedure makes the process easier and reduces the chance of pancreatitis afterward. 152 patients were randomly assigned to either standard cannulation or forceps-assisted cannulation. …

This study tested whether a procedure called pancreatic endotherapy can reduce pain in people with chronic pancreatitis whose main pancreatic duct is blocked by stones or narrowings. Fourteen adults with severe daily pain were randomly assigned to get either an ultrasound alone o…

This study tested a mobile app that gives personalized encouragement and health insights based on blood sugar, exercise, mood, and sleep patterns. The goal was to help 24 middle-aged adults with type 1 diabetes or similar conditions exercise more often and confidently. The app ai…

This study compares two procedures for breaking up large stones in the pancreatic duct of people with chronic pancreatitis. One method uses shock waves from outside the body, while the other uses a tiny scope and laser during an ERCP. The goal is to see which technique clears sto…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study reviewed medical records of 148 adults admitted to the ICU with severe acute pancreatitis. The goal was to find risk factors for infected pancreatic necrosis, a serious complication that raises the risk of death. By identifying these factors, doctors hope to diagnose a…

This study creates a registry of adults with pancreatic exocrine insufficiency (PEI), a condition where the pancreas does not produce enough enzymes to digest food properly. Researchers at eight specialist centers across Europe will track how doctors prescribe pancreatic enzyme r…

This completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…

This completed study looked at 141 people with acute pancreatitis to understand how blood clotting changes during the illness. Researchers took blood samples over several days and will analyze them for markers that might predict whether the disease becomes mild, moderate, or seve…

This study looked at how emergency general surgery affects pregnant women and their unborn babies. Researchers planned to follow pregnant women who needed surgery for problems like appendicitis or gallbladder disease. The goal was to learn more about the safety of these surgeries…

This completed study created a registry of 400 adults with exocrine pancreatic insufficiency (EPI) caused by chronic pancreatitis. Researchers collected real-world data on disease history, treatment patterns, and quality of life through patient reports and clinic visits. The goal…

This study looked at whether measuring pancreatic polypeptide levels after a meal can help doctors tell the difference between type 1 diabetes and type 3c diabetes (caused by pancreas damage). Thirty-six adults with either type 1 or type 3c diabetes gave blood and stool samples. …

This study looked at 445 patients with mild acute biliary pancreatitis to compare having gallbladder removal surgery during the same hospital stay versus waiting for a later date. The goal was to see which approach leads to fewer repeat hospital visits for gallstone-related probl…

This study looked at whether enzyme therapy helps people with chronic pancreatitis absorb protein better. Eleven participants took part to measure how their bodies used dietary nitrogen. The goal was to understand if current enzyme treatments are effective for protein digestion.

This study tested a computer model (XGBoost) to predict whether suspicious spots on CT scans in people with chronic pancreatitis are cancerous. Researchers analyzed data from 113 patients to see how accurate the model was. The goal is to help doctors make better decisions without…

This study tested the EchoTip AcuCore, a needle used during endoscopic ultrasound to collect tissue samples from the pancreas, liver, and other organs. 183 adults with conditions like cancer or chronic pancreatitis took part. The main goal was to see if the needle could get a goo…

This completed study looked at data from over 723,000 older adults (70+) worldwide to understand how common pancreatic cancer and pancreatitis are, and how deadly they are. Researchers analyzed trends from 1990 to 2021 and made projections to 2040. The goal was to see how these d…