Pancreatitis

This study investigates whether giving phosphate through an IV can reduce the severity of acute pancreatitis in adults. Researchers want to know if low phosphate levels make the disease worse and if replenishing it helps. Participants receive either standard care or IV phosphate …

This trial investigates whether flushing the bile duct opening with ice-cold water after an ERCP procedure can reduce the chance of developing pancreatitis, a frequent complication. Researchers will compare patients who receive the flush to those who do not, looking at pancreatit…

This trial tests whether a procedure called EUS-guided gallbladder drainage can prevent future gallbladder attacks in people who are too sick or frail for surgery. Participants are randomly assigned to receive either the drainage procedure or standard medical care. The study will…

This study tests whether giving the blood thinner heparin early can prevent organ failure in people hospitalized with acute pancreatitis. The inflammation from pancreatitis can cause tiny blood clots that damage organs like the lungs and kidneys. Half of the 100 participants will…

This study looks at whether a preventive endoscopic procedure (sphincterotomy) can lower the risk of future bile duct problems in frail patients who cannot have their gallbladder removed after a bout of pancreatitis caused by gallstones. About 92 adults will be randomly assigned …

This study looks at 30 people with mild gallstone-related pancreatitis who choose not to have their gallbladder removed. Half will get an ERCP with sphincterotomy (a procedure that opens the bile duct), and half will receive standard care without the procedure. The goal is to see…

This early-phase study tests a surgery that removes the entire pancreas and then transplants the patient's own insulin-making cells into the liver. The goal is to treat chronic pancreatitis and benign tumors while reducing the risk of diabetes. The study includes 12 adults with a…

This study tests whether taking pancreatic enzyme pills can help people who have lost significant weight after a severe bout of pancreatitis regain a healthier body weight. The trial will enroll 188 adults aged 18-60 who have lost at least 10% of their body weight due to the dise…

This study tests a new blood test that combines genetic sequencing and immune response analysis to quickly tell if dead pancreatic tissue has become infected. Researchers will enroll 200 patients with severe pancreatitis across four hospitals. If accurate, this test could help do…

This trial tests whether a single dose of rectal indomethacin, a common anti-inflammatory drug, can prevent pancreatitis in patients undergoing a bile duct procedure (ERCP) who have had a prior sphincterotomy. About 860 adults will be randomly assigned to receive the drug or no d…

This study tests whether semaglutide (Ozempic/Wegovy) can prevent repeat episodes of acute pancreatitis caused by very high triglycerides. About 396 adults who recently had such an attack will receive either semaglutide injections or a placebo for 18 months, alongside standard ca…

This study compares two doses of a rectal anti-inflammatory drug (indomethacin) to prevent pancreatitis after an ERCP procedure in people at high risk. About 1,036 adults will be randomly assigned to receive either 100 mg or 200 mg right after the procedure. The goal is to see if…

This study tests a special oxygen tube placed in the mouth during a procedure called ERCP, which is used to treat bile duct and pancreas problems. The goal is to see if this method can prevent low oxygen levels that often happen when patients are deeply sedated. About 410 adults …

This study compares home management versus standard hospital care for people with mild acute pancreatitis. Participants will be randomly assigned to either go home with daily phone check-ins and a clinic visit, or stay in the hospital. The goal is to see if home care is as safe a…

This study tests whether a specially designed, better-tasting liquid diet can be used for two weeks by adults with chronic pancreatitis who have bothersome stomach symptoms. The diet is an easy-to-absorb formula that replaces all food for 14 days. Researchers want to see if peopl…

This study tests whether using a virtual reality headset at home can help adults with chronic pancreatitis manage their pain. Twenty participants will use either a gut-directed VR therapy or a distraction-based VR for 8 weeks. The main goal is to see if people can stick with the …

This study compares an oral carbohydrate solution (a sugar drink) to a standard clear liquid diet as the first food given to people with mild to moderate acute pancreatitis. The goal is to see which approach causes fewer problems like pain or nausea and leads to a shorter hospita…

The EXPAND study is a research project that will enroll 440 adults with and without pancreatic conditions to understand why type 2 diabetes varies so much from person to person. Researchers will collect data on metabolism, genetics, and pancreas health to identify distinct diabet…

This study looks at two scoring systems, NEWS-2 and NEWS-Calcium, to see which better predicts the risk of dying in the hospital for people aged 65 and older with acute pancreatitis. Researchers will review medical records of 350 patients to compare the scores. The goal is to hel…

This study looks at why some patients develop blood clots after pancreatic surgery that also involves removing a piece of a major vein. Researchers will collect information from over 1,000 patients across many hospitals to see how surgical techniques and blood-thinning medication…

This study will follow 800 people, including those with chronic pancreatitis, pancreatic cancer, and healthy volunteers, to learn why some pancreatitis patients later get pancreatic cancer. Participants give blood samples and health info; some may also provide tissue samples. Res…

This study will check 100 adults with chronic pancreatitis or who had part of their pancreas removed. Even though they take enzyme pills, they still have stomach pain, bloating, or diarrhea. Researchers will use breath tests to see if a condition called SIBO (too much bacteria in…

This study aims to detect and measure microplastics in pancreas tissue from 10 patients having pancreatic surgery. Researchers will also check fat tissue and blood samples. The goal is to see if microplastics are present and whether they might be linked to metabolic problems or c…

This study aims to create an artificial intelligence (AI) system that can combine medical images (like CT and MRI scans) with patient records and lab results to help doctors more accurately diagnose diseases of the liver, gallbladder, and pancreas. The researchers will use data f…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will compare two different schedules for removing pancreatic stents placed during ERCP to prevent pancreatitis. One group will have the stent removed after 1-3 months, while the other will have it removed within 10 days. The goal is to see which timing leads to fewer c…

This study looks at whether the ratio of C-reactive protein to albumin (CAR) in the blood can help predict acute kidney injury in people with acute pancreatitis. Researchers will measure CAR in 150 adults admitted to Assiut University Hospitals and see how it relates to kidney pr…

This study will look at whether certain markers from a standard complete blood count (CBC) can help doctors assess how severe acute pancreatitis is and predict patient outcomes. Researchers will analyze data from 100 adult patients treated for acute pancreatitis. The goal is to s…

This study will review medical records of 700 adults with severe pancreatitis and sepsis who had surgery to remove dead tissue. Researchers want to see how organ function changes over time after the operation. The goal is to better understand recovery patterns and outcomes.

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…