Pancreatitis

This phase 2 trial is testing whether pirfenidone, a drug already used for lung scarring, can help people with chronic pancreatitis—a long-term inflammation of the pancreas that causes severe pain. The study will enroll 60 adults with chronic pancreatitis and moderate-to-severe p…

This study tests whether giving the blood thinner heparin early can prevent organ failure in people hospitalized with acute pancreatitis. The inflammation from pancreatitis can cause tiny blood clots that damage organs like the lungs and kidneys. Half of the 100 participants will…

This trial tests whether a special cooling tube placed near the pancreas can help people with acute pancreatitis recover faster. Participants are randomly assigned to receive either standard care alone or standard care plus the cooling device for up to three days. The study measu…

This trial compares fungal-based pancreatic enzymes to standard pig-derived enzymes in people with chronic pancreatitis and digestive insufficiency. Participants take either the fungal or porcine enzyme for 12 weeks to see if the fungal version works just as well. The goal is to …

This Phase 3 trial tests an investigational biologic called DR10624, given as a weekly injection, in adults with severe hypertriglyceridemia (very high blood fats) who are already on standard lipid-lowering therapy. The study compares two doses of DR10624 against a placebo to see…

This trial investigates whether flushing the bile duct opening with ice-cold water after an ERCP procedure can reduce the chance of developing pancreatitis, a frequent complication. Researchers will compare patients who receive the flush to those who do not, looking at pancreatit…

This trial tests whether a procedure called EUS-guided gallbladder drainage can prevent future gallbladder attacks in people who are too sick or frail for surgery. Participants are randomly assigned to receive either the drainage procedure or standard medical care. The study will…

This study looks at whether a preventive endoscopic procedure (sphincterotomy) can lower the risk of future bile duct problems in frail patients who cannot have their gallbladder removed after a bout of pancreatitis caused by gallstones. About 92 adults will be randomly assigned …

This study looks at 30 people with mild gallstone-related pancreatitis who choose not to have their gallbladder removed. Half will get an ERCP with sphincterotomy (a procedure that opens the bile duct), and half will receive standard care without the procedure. The goal is to see…

This early-phase study tests a surgery that removes the entire pancreas and then transplants the patient's own insulin-making cells into the liver. The goal is to treat chronic pancreatitis and benign tumors while reducing the risk of diabetes. The study includes 12 adults with a…

This study tests whether taking pancreatic enzyme pills can help people who have lost significant weight after a severe bout of pancreatitis regain a healthier body weight. The trial will enroll 188 adults aged 18-60 who have lost at least 10% of their body weight due to the dise…

This study tests a new blood test that combines genetic sequencing and immune response analysis to quickly tell if dead pancreatic tissue has become infected. Researchers will enroll 200 patients with severe pancreatitis across four hospitals. If accurate, this test could help do…

This trial tests whether a single dose of rectal indomethacin, a common anti-inflammatory drug, can prevent pancreatitis in patients undergoing a bile duct procedure (ERCP) who have had a prior sphincterotomy. About 860 adults will be randomly assigned to receive the drug or no d…

This study tests whether semaglutide (Ozempic/Wegovy) can prevent repeat episodes of acute pancreatitis caused by very high triglycerides. About 396 adults who recently had such an attack will receive either semaglutide injections or a placebo for 18 months, alongside standard ca…

This study compares two doses of a rectal anti-inflammatory drug (indomethacin) to prevent pancreatitis after an ERCP procedure in people at high risk. About 1,036 adults will be randomly assigned to receive either 100 mg or 200 mg right after the procedure. The goal is to see if…

This study tests whether using a virtual reality headset at home can help adults with chronic pancreatitis manage their pain. Twenty participants will use either a gut-directed VR therapy or a distraction-based VR for 8 weeks. The main goal is to see if people can stick with the …

This study tests whether a thoracic epidural block—a numbing injection near the spine—can help people with severe acute pancreatitis avoid or shorten the need for intensive care support like breathing machines and kidney dialysis. Participants are randomly assigned to receive eit…

This study compares home management versus standard hospital care for people with mild acute pancreatitis. Participants will be randomly assigned to either go home with daily phone check-ins and a clinic visit, or stay in the hospital. The goal is to see if home care is as safe a…

This study tests a special oxygen tube placed in the mouth during a procedure called ERCP, which is used to treat bile duct and pancreas problems. The goal is to see if this method can prevent low oxygen levels that often happen when patients are deeply sedated. About 410 adults …

This study tests whether a specially designed, better-tasting liquid diet can be used for two weeks by adults with chronic pancreatitis who have bothersome stomach symptoms. The diet is an easy-to-absorb formula that replaces all food for 14 days. Researchers want to see if peopl…

This study compares an oral carbohydrate solution (a sugar drink) to a standard clear liquid diet as the first food given to people with mild to moderate acute pancreatitis. The goal is to see which approach causes fewer problems like pain or nausea and leads to a shorter hospita…

This observational study is investigating whether certain blood markers and gut microorganisms can help identify people with chronic pancreatitis who are at higher risk of developing pancreatic cancer. Researchers will compare healthy individuals, those with chronic pancreatitis,…

This study looks at adults with acute pancreatitis, a sudden inflammation of the pancreas, to understand the different ways it presents and what happens to patients. Researchers will track 100 participants to identify patterns and potential predictors of outcomes. The goal is to …

This study looks at whether early endoscopic findings in the stomach and duodenum can help predict how severe acute pancreatitis will become. Researchers will perform an upper GI endoscopy within 24-48 hours of hospital admission in 200 adult patients with acute pancreatitis. The…

The EXPAND study is a research project that will enroll 440 adults with and without pancreatic conditions to understand why type 2 diabetes varies so much from person to person. Researchers will collect data on metabolism, genetics, and pancreas health to identify distinct diabet…

This study looks at two scoring systems, NEWS-2 and NEWS-Calcium, to see which better predicts the risk of dying in the hospital for people aged 65 and older with acute pancreatitis. Researchers will review medical records of 350 patients to compare the scores. The goal is to hel…

This study looks at why some patients develop blood clots after pancreatic surgery that also involves removing a piece of a major vein. Researchers will collect information from over 1,000 patients across many hospitals to see how surgical techniques and blood-thinning medication…

This study will follow 800 people, including those with chronic pancreatitis, pancreatic cancer, and healthy volunteers, to learn why some pancreatitis patients later get pancreatic cancer. Participants give blood samples and health info; some may also provide tissue samples. Res…

This study will check 100 adults with chronic pancreatitis or who had part of their pancreas removed. Even though they take enzyme pills, they still have stomach pain, bloating, or diarrhea. Researchers will use breath tests to see if a condition called SIBO (too much bacteria in…

This study will compare two different schedules for removing pancreatic stents placed during ERCP to prevent pancreatitis. One group will have the stent removed after 1-3 months, while the other will have it removed within 10 days. The goal is to see which timing leads to fewer c…

This study looks at whether the ratio of C-reactive protein to albumin (CAR) in the blood can help predict acute kidney injury in people with acute pancreatitis. Researchers will measure CAR in 150 adults admitted to Assiut University Hospitals and see how it relates to kidney pr…

This study will look at whether certain markers from a standard complete blood count (CBC) can help doctors assess how severe acute pancreatitis is and predict patient outcomes. Researchers will analyze data from 100 adult patients treated for acute pancreatitis. The goal is to s…

This study will review medical records of 700 adults with severe pancreatitis and sepsis who had surgery to remove dead tissue. Researchers want to see how organ function changes over time after the operation. The goal is to better understand recovery patterns and outcomes.

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…