Pancreas disorder

This early-stage study tests a vaccine designed to train the immune system to attack cells with a mutated KRAS gene, which is common in pancreatic cancer. The vaccine is given to people at high risk due to family history or pancreatic cysts. The main goals are to see if the vacci…

This study is testing whether limiting all food intake to a 10-hour window each day can help people with type 2 diabetes better manage their blood sugar. About 102 adults will follow this eating pattern for one year, tracking their first and last meals by text. Researchers will c…

This phase 2 trial tests whether specially selected immune cells taken from a patient's own tumor, grown in large numbers in the lab, and given back along with the drug pembrolizumab (Keytruda) can shrink tumors in people with metastatic colorectal, pancreatic, ovarian, breast, o…

This study tests a new automatic insulin pump (Omnipod M) in 350 adults with type 2 diabetes who already use insulin. The pump adjusts insulin delivery on its own to keep blood sugar in a healthy range. The goal is to see if it improves blood sugar control and is safe to use.

This study compares a new insulin pump system, Omnipod 6, to the current Omnipod 5 in 200 people with type 1 or type 2 diabetes who have poor blood sugar control. Participants will use both pumps for a set time to see which one helps keep blood sugar in a healthy range more effec…

This early-phase trial tests a new drug called metarrestin in people with advanced solid tumors that have spread (metastasized). The goal is to find a safe dose and see if it can shrink tumors. The study includes adults with pancreatic, breast, or other solid tumors, and children…

This early-phase study tests an experimental drug called DM002 in about 160 people with advanced solid tumors (ovarian, prostate, endometrial, colorectal, or other solid cancers). The study has two parts: first, finding a safe dose by giving small groups gradually higher doses; s…

This study tests a new medicine called HM15275 in people with type 2 diabetes. The goal is to see if it can lower blood sugar levels (HbA1c) safely over 36 weeks. About 180 adults who manage their diabetes with diet, exercise, or metformin will take part. Half will get the drug, …

This study tests a new medicine called ANG003 for people with cystic fibrosis who have trouble digesting food (exocrine pancreatic insufficiency). The medicine is a type of enzyme replacement therapy, similar to the current standard treatment Creon. About 113 participants will re…

This early-stage trial is testing an experimental drug called BMS-986488, alone or combined with other cancer drugs, in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and find the right dose. About 437 adults w…

This study tests whether a real-time continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes keep their blood sugar in a healthy range better than standard finger-prick testing. About 240 women in early pregnancy will either wear the CGM device for most of thei…

This 12-month pilot study tests whether a nurse-led smartphone app can help Medicaid patients with insulin-treated type 2 diabetes improve their blood sugar control. The program combines educational messages, phone-based problem-solving with a nurse, and remote monitoring via a d…

This study tests a new drug called ASP546C in people with advanced stomach, gastroesophageal junction, pancreatic, or certain other solid tumors. The drug is given as an infusion every 3 weeks. The study has two parts: Part 1 finds the best dose in stomach/GEJ cancer patients, an…

This study tests a new oral drug, VS-7375, alone or with another drug (cetuximab), in 180 people with metastatic pancreatic cancer that has a specific genetic change called KRAS G12D. The goal is to see if the drug shrinks tumors and is safe. Participants must have this mutation …

This phase II trial is testing whether the drug olaparib can help prevent pancreatic cancer from coming back in people who have already had surgery and chemotherapy and carry a BRCA1, BRCA2, or PALB2 mutation. Olaparib is a targeted therapy that blocks a repair enzyme cancer cell…

This study looks at how well the Omnipod 5 Automated Insulin Delivery System works in real-world settings for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar levels in a h…

This study tests a new drug, CNP-103, in people aged 12 to 35 who were diagnosed with stage 3 type 1 diabetes within the last 6 months. The goal is to see if the drug is safe and can help control the disease. Participants will receive either the drug or a placebo, and researchers…

This study tests whether adding a targeted, tumor-destroying treatment (like focused radiation or heat ablation) can help people with certain gastrointestinal cancers—such as colorectal, small bowel, or pancreatic cancer—continue their current systemic therapy longer when only a …

This study looks at how well the drug cabozantinib works and how safe it is for adults with neuroendocrine tumors (NETs) that have continued to grow after at least one prior treatment. About 150 participants in Germany and Austria will be followed during their routine care. Docto…

This study tests whether teplizumab, a drug already approved in the US, can safely delay the start of full-blown type 1 diabetes in Japanese people aged 8 to 34 who are at high risk (Stage 2). Participants will receive a 14-day IV treatment and be monitored for side effects and h…

This early-stage trial tests a new type of immunotherapy where a patient's own T cells are genetically engineered to recognize and attack cancer cells with a specific KRAS G12D mutation. The study includes adults with advanced lung, colorectal, pancreatic, or endometrial cancers …

This study is testing a new biologic drug called sacituzumab tirumotecan (MK-2870), alone or with chemotherapy, in people with advanced colorectal, pancreatic, or biliary tract cancers that cannot be removed by surgery. The main goals are to check safety and see if tumors shrink.…

This study will follow 2,200 children and adults with type 1 diabetes who are using the Omnipod 5 system, a tubeless insulin pump that automatically adjusts insulin based on continuous glucose monitor readings. Over 12 months, researchers will track how often severe low or high b…

This Phase 3 trial will test a new once-daily insulin, GZR33, against the standard insulin degludec (Tresiba) in 350 adults with type 2 diabetes whose blood sugar is not well controlled by oral medications. The main goal is to see how well GZR33 lowers blood sugar over 26 weeks c…

This study offers a free 3-month diabetes education program at a local faith-based organization for adults with diabetes or prediabetes in Jefferson County, Alabama. Participants attend group sessions on diet, exercise, and coping, and are paired with a community health worker fo…

This trial tests whether a pulse electric field ablation system can help adults with type 2 diabetes whose blood sugar is not well controlled by oral medications. The study enrolls 20 people aged 18 to 70 with a specific range of blood sugar levels. Researchers will measure chang…

This early-stage study tests a new oral drug, DEG6498, in about 100 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and understand side effects. Participants take the drug once daily and are closely monitore…

This study tests a new drug called BMS-986340, alone or with other cancer treatments, in people with advanced solid tumors like lung, colon, or breast cancer. The goal is to find safe doses and check for side effects. About 1,100 adults with tumors that have worsened after standa…

This study tests whether placing a small tube (stent) in the pancreas during Whipple surgery can prevent a common complication called pancreatic fistula, where digestive fluid leaks out. The trial will compare 100 patients with a soft pancreas who either get the stent or not. The…

This Phase 3 trial is testing whether adding a new targeted pill (INCB161734) to standard chemotherapy helps people with a specific type of advanced pancreatic cancer (KRAS G12D mutation) live longer. About 588 participants who have not had prior treatment for metastatic disease …

This study looks at whether adding GLP-1 receptor agonists or SGLT inhibitors to insulin helps adults with type 1 diabetes manage their blood sugar better. Researchers will track 300 participants for one year, measuring changes in HbA1c and other health markers. The goal is to se…

This study tests a program for adults with type 2 diabetes who are leaving the hospital. Participants will work with a patient navigator to address unmet social needs like food, housing, or transportation. The goal is to see if this support reduces emergency visits and readmissio…

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps adults with prediabetes better control their blood sugar and stick to lifestyle changes compared to standard finger-prick testing. About 80 participants will be randomly assigned to use a CGM o…

This study will give 800 pregnant women biweekly food kits with fruits, vegetables, and other healthy foods to see if it improves their diet and pregnancy outcomes. Participants will be followed from early pregnancy through birth. The goal is to learn whether providing healthy fo…

This large Phase 2/3 trial is testing whether adding an investigational drug called telisotuzumab adizutecan to standard chemotherapy (FOLFOX) can help people with metastatic pancreatic cancer live longer or shrink their tumors. About 900 participants will be randomly assigned to…

This study tests whether a 12-week personalized exercise program done at home and guided by a mobile app and wearable device can improve blood sugar control and physical fitness in adults with type 2 diabetes. Participants are 40 to 69 years old, newly diagnosed or with diabetes …

This early-stage trial tests whether TIX100, a daily oral pill, is safe and tolerable in healthy adults who are overweight or obese. Over 28 days, participants receive either TIX100 or a placebo, and researchers monitor for side effects and how the drug moves through the body. Th…

This study compares two lifestyle programs for people with type 2 diabetes or prediabetes: one using a ketogenic diet and the other a low-fat diet. Over 12 months, researchers will track changes in weight, blood sugar, blood pressure, and heart health. The goal is to see which di…

This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. About 130 adults with uncontrolled high blood pressure will receive the quicker procedure. The goal is to see if it works…

This study investigates whether combining intranasal insulin (delivered as a nose spray) with high-intensity exercise can improve brain blood flow, insulin sensitivity, and thinking skills in older adults with type 2 diabetes. Participants aged 55–80 will receive either insulin o…

This study tests a new smartphone-based system that automatically delivers insulin for people with type 1 diabetes. Six adults who already use insulin pumps will try the system for a short time under close supervision. The goal is to see if the technology works safely and reliabl…

This study tests a treatment called VX-880 for people with type 1 diabetes who have dangerous low blood sugar episodes. The therapy uses donor cells that can produce insulin, aiming to let participants stop taking insulin shots and avoid severe hypoglycemia. About 52 adults with …

This phase 2 study tests an experimental drug called BT5528 in adults with metastatic pancreatic cancer that has spread and worsened after one prior treatment. The drug targets a specific protein on cancer cells. Researchers will measure how well it shrinks tumors and track side …

This study tests a new once-weekly injection called NNC0662-0419 in 270 adults with type 2 diabetes. It compares the drug against a placebo and an approved medication, semaglutide, to see how well it controls blood sugar and promotes weight loss. The trial is currently recruiting…

This study tests whether giving people access to healthy foods, personalized dietitian coaching, and a home blood pressure monitor can help Black and Hispanic adults with high blood pressure (and often diabetes) get their numbers down. About 100 participants will be randomly assi…

This study tests whether montelukast, a common allergy medication, can lower protein levels in urine and improve kidney and blood vessel function in people with type 1 diabetes who have early signs of kidney disease. Inflammation is thought to play a role in diabetic kidney damag…

This study compares continuous glucose monitoring (CGM) to standard fingerstick testing for pregnant women with type 2 diabetes. Researchers want to see if CGM leads to better blood sugar control and fewer complications for both mother and baby. Participants wear a CGM device or …

This study follows 630 people with type 1 diabetes in Japan who are already prescribed Awiqli, a once-weekly injection. Researchers will track side effects and blood sugar control over one year to see how the drug works in everyday life. The goal is to manage diabetes, not cure i…

This study tests whether a continuous glucose monitor (CGM) paired with a coaching app helps pregnant women with type 2 diabetes achieve better blood sugar control compared to standard care. Participants use a Dexcom G7 CGM sensor and receive guidance through a mobile app and car…

This study compares a new insulin that is injected once a week (insulin icodec) to a standard daily insulin (insulin glargine) in about 877 adults with type 1 diabetes. The goal is to see if the weekly insulin controls blood sugar just as well as the daily one. Participants will …

This early-stage trial tests a new drug called YL211 in 155 people with advanced solid tumors who have no standard treatment options left. The study has three parts: first, finding a safe dose; then, confirming that dose; and finally, testing how well it works. The main goals are…

This early-phase trial is testing an experimental oral drug called KST-6051 in adults with advanced or metastatic solid tumors that have a KRAS mutation, including certain lung, pancreatic, and colorectal cancers. The main goal is to check the drug's safety and how the body proce…

This study tests a new care model for 80 young adults with type 1 diabetes who are moving from pediatric to adult healthcare. The program includes a nurse educator, psychologist, and transition navigator working together to provide support over six months. The goal is to see if t…

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and …

This study tests whether semaglutide, a diabetes drug, is safe and tolerable for people with type 2 diabetes who are on dialysis. About 100 participants will either receive weekly semaglutide injections or standard care for 26 weeks. The goal is to see if patients can stick with …

This study tests whether a fully closed-loop insulin system (which automatically adjusts insulin delivery) works better than a standard insulin pump for people with type 2 diabetes. Eighty adults who have used an insulin pump for at least six months will try both methods for 12 w…

This phase 3 trial is testing a once-weekly injection called enicepatide in 300 Chinese adults who are obese or overweight, with or without type 2 diabetes. The drug works by mimicking two gut hormones to reduce appetite and improve blood sugar control. Participants will receive …

This phase 3 trial tests a drug called plozasiran in 288 adults with severe hypertriglyceridemia (very high blood fats) who have had at least two pancreatitis attacks. Participants receive either the drug or a placebo every three months. The main goal is to see if the drug can pr…

This phase 2 study tests belzutifan, a daily pill that blocks a protein called HIF-2α, in people with advanced rare cancers like pheochromocytoma/paraganglioma, pancreatic neuroendocrine tumors, VHL disease-associated tumors, and certain other solid tumors. The goal is to see if …

This study tests a new daily pill, GFH375, against standard chemotherapy in 320 people with advanced pancreatic cancer that has a specific KRAS G12D gene mutation. Participants must have already tried at least one standard treatment. The goal is to see if the new drug helps peopl…

This Phase 2 trial tests two experimental drugs, ALN-ANG3 and evinacumab, in 270 people with diabetic kidney disease. The drugs block a protein called ANGPTL3 to lower blood fats. Researchers will measure changes in urine protein and kidney function over time to see if the drugs …

This study tests an experimental drug called ARO-INHBE in 180 adults with obesity, some of whom also have type 2 diabetes. The drug is given as a shot under the skin, either alone or combined with the existing weight-loss drug tirzepatide. The main goal is to check safety and how…

This early-stage trial is testing whether adding an experimental cancer vaccine (ELI-002 7P) and an immunotherapy drug (tislelizumab) to standard chemotherapy (mFOLFIRINOX) is safe and effective for people with a specific type of pancreatic cancer that has a KRAS mutation. The st…

This study tests whether providing money specifically for healthy foods helps pregnant women avoid gaining too much weight. About 1,440 women will either get standard nutrition advice or that plus up to $3,000 for healthy groceries. Researchers will compare weight gain between th…

This study tests whether taking three cholesterol-lowering drugs together works better than taking two in people with type 2 diabetes and high LDL cholesterol. 126 adults aged 35-60 will be split into three groups: one gets rosuvastatin plus ezetimibe, another gets bempedoic acid…

This study tests a freezing device called a cryoprobe to remove dead tissue from the pancreas in people with a serious complication of acute pancreatitis. Instead of using standard tools like forceps or snares, the cryoprobe freezes the dead tissue so it can be pulled out more ea…

This study tests whether baricitinib, a pill, can help preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes. About 300 children and young adults (ages 1 to under 36) will take either baricitinib or a placebo for 60 weeks. The goal is to see i…

This study tests a new once-weekly medicine called eloralintide to help people with obesity or overweight and type 2 diabetes lose weight. About 1035 adults will receive either the drug or a placebo for around 75 weeks. Researchers will measure changes in body weight, fat, waist …

This study explores whether growing miniature versions of a patient's own pancreatic tumor in the lab (called organoids) can help doctors choose the most effective drug for that individual. About 25 adults with advanced, inoperable pancreatic cancer will have their tumor organoid…

This study tests a new approach for locally advanced pancreatic cancer: tiny radioactive sources placed directly into the tumor to deliver alpha radiation. The treatment is combined with standard chemotherapy. The main goal is to check safety in 40 participants, but researchers w…

This phase III trial tests whether giving a higher dose of radiation can help people with locally advanced pancreatic cancer live longer. Participants must have already had 4-6 months of chemotherapy. The study compares higher-dose radiation to standard care (more chemo, observat…

This study compares two blood sugar targets for overweight or obese women with gestational diabetes. One group aims for stricter goals (fasting under 90 mg/dL, after meals under 120 mg/dL), while the other follows standard targets (fasting under 95 mg/dL, after meals under 140 mg…

This early-stage trial tests whether injecting an immune-boosting drug (mitazalimab) directly into the tumor during a special electrical ablation procedure (IRE) is safe for people with locally advanced pancreatic cancer. The goal is to see if this approach can strengthen the bod…

This study tests whether a 12-week low-calorie meal replacement diet can improve heart function and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) who are also obese. 63 adults will be randomly assigned to either the diet or standard care. …

This phase 3 trial tests a new drug called daraxonrasib, taken as a pill, either alone or with standard chemotherapy, against chemotherapy alone for people with metastatic pancreatic cancer. About 900 adults with confirmed pancreatic cancer that has spread will be randomly assign…

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…

This study looks at whether a second islet transplant can safely improve blood sugar control in adults with type 1 diabetes whose first transplant stopped working. Researchers will follow 20 patients for up to 5 years, checking graft function, insulin use, and severe low blood su…

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will receive the drugs or a placebo for 48 weeks. The main goal is to see how much weight the…

This phase 3 trial tests whether adding setidegrasib (ASP3082) to standard chemotherapy helps people with a specific KRAS G12D mutation in metastatic pancreatic cancer live longer. About 614 adults will be randomly assigned to receive either setidegrasib or a placebo, along with …

This study looks at whether removing the entire pancreas is better than removing just part of it for people with certain cancers in the head of the pancreas who are at high risk of complications. The main goal is to see if total removal helps patients live longer without hurting …

This study tests a device called the iLet Bionic Pancreas, which automatically adjusts insulin delivery based on continuous glucose monitor readings, in people with cystic fibrosis-related diabetes. About 150 participants aged 14 and older will either use the bionic pancreas or t…

This early-stage study tests a new drug called azirkitug, alone or with other cancer medicines, in people with advanced solid tumors like lung, head/neck, and pancreatic cancers. The goal is to find safe doses and check side effects. About 694 adults will take part worldwide, rec…

This study tests a device that uses radiofrequency energy to disrupt nerve signals in the kidney and liver arteries, aiming to lower blood pressure in people with uncontrolled hypertension. About 175 adults aged 18-80 with high blood pressure despite medication will be enrolled. …

This study compares two advanced heart procedures—stenting guided by imaging and blood flow tests (PCI) versus bypass surgery (CABG)—in 1,500 people with diabetes and three blocked coronary arteries. The goal is to see which approach better prevents major events like death, heart…

This study compares two treatments for gestational diabetes: oral metformin pills and injectable insulin. Researchers want to see if metformin is as good as insulin at preventing problems for mothers and babies, like high birth weight or low blood sugar. About 1,500 pregnant wome…

This early-stage study tests a new drug, AMG 127, to see if it is safe for people. It involves 162 healthy adults and people with type 2 diabetes. Researchers will give single or multiple doses and watch for side effects. This is a first step to see if the drug can be developed f…

This study is testing a new approach for people with obesity and type 2 diabetes. It combines two procedures done through the mouth: one uses mild electric pulses to regenerate the lining of the upper intestine, and the other reduces stomach size by stitching it like a sleeve. Th…

This study tests whether meals designed for South Asian and Filipino cultures, following diabetes guidelines, can improve blood sugar control in people with type 2 diabetes. Thirty participants will wear a continuous glucose monitor for a month while eating their usual diet and t…

This study tests a three-drug chemotherapy regimen given at lower, continuous doses for people with metastatic pancreatic cancer. The drugs—capecitabine, oxaliplatin, and irinotecan—are dosed based on a patient's genetic profile to reduce side effects. The goal is to see if this …

This phase 2 trial is testing whether giving two immunotherapy drugs, durvalumab and oleclumab, before surgery can boost the immune system's attack on pancreatic cancer. The study involves people with resectable pancreatic ductal adenocarcinoma (PDAC) who will receive the drugs i…

This early-stage trial is testing a new drug called IDE892, alone or with another drug (IDE397), in people with advanced solid tumors that have a specific genetic deletion (MTAP). The study aims to find safe doses and see if the drugs shrink tumors. It includes 260 adults with ca…

This study tests a new medicine called LY3938577 against a standard insulin (degludec) in 100 adults with type 2 diabetes who already use basal insulin. The goal is to see if the new drug helps keep blood sugar in a healthy range more safely and effectively over about 26 weeks. P…

This Phase 2 trial tests an experimental drug called LY3457263 in 240 adults with type 2 diabetes who still have high blood sugar despite taking stable doses of semaglutide or tirzepatide. Participants receive weekly injections of either the new drug or a placebo for about 9 mont…

This Phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 1600 people who are obese or overweight and also have type 2 diabetes. The drug works by mimicking natural hormones that help control appetite and blood sugar. Participants will receive eit…

This early-phase trial tests an experimental drug called RSC-1255, given alone or with hydroxychloroquine, in people with advanced solid tumors (like lung, colon, or pancreatic cancer) who have run out of standard options. The study has two parts: first, finding a safe dose, and …

This study compares two ways of tracking blood sugar in people with type 2 diabetes who use insulin after leaving the hospital. One group uses a continuous glucose monitor (CGM) that shows real-time levels and trends, while the other group uses traditional fingerstick tests. The …

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This early-stage study is testing a new drug called M0324, a bispecific antibody designed to target cancer cells. The trial will look at M0324 alone, with the immunotherapy pembrolizumab, and with chemotherapy in about 77 people with advanced solid tumors that have not responded …

This study is testing a mobile app called Adhera Caring Digital Program for Obesity (ACDP-O) in 280 families. The app provides personalized education, mental health monitoring, and wearable device integration to support weight management and well-being in adolescents and young ad…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study tests whether removing as much tumor as possible through surgery before giving a targeted radioactive drug (Lutetium Lu 177 dotatate) works better for people with slow-growing neuroendocrine tumors that have spread to the liver. Six adults with grade 1 or 2 tumors will…

This early-phase study tests a new oral drug called GS-4571 in healthy people, non-diabetic obese individuals, and non-obese people with type 2 diabetes. The main goals are to see how the drug moves through the body, how safe it is, and how food or acid-reducing drugs affect it. …

This Phase 3 trial tests whether adding an experimental oral drug called atebimetinib to a modified chemotherapy regimen helps people with metastatic pancreatic cancer live longer. About 510 adults who have not had prior treatment will receive either the new combination or standa…

This early-stage trial tests IM-1021, an antibody-drug conjugate designed to deliver a cancer-killing drug directly to tumor cells. It enrolls 117 adults with advanced solid tumors or B-cell lymphomas that have not responded to standard treatments. The main goals are to check saf…

This study tests whether wearing a continuous glucose monitor (CGM) helps pregnant women with gestational diabetes control their blood sugar and improve outcomes for both mother and baby. Researchers will also examine how socioeconomic status, diet, and culture affect results. Th…

This phase 2 trial is testing the drug talazoparib in people with advanced solid tumors that have specific mutations in DNA repair genes. Talazoparib works by blocking a protein called PARP, which cancer cells use to fix their damaged DNA, leading to cancer cell death. The study …

This study compares two different strength training schedules—non-linear and linear periodization—in people with type 2 diabetes. Over 8 weeks, 48 participants will do supervised workouts three times a week or receive usual care. Researchers will measure changes in exercise capac…

This study tests a device called ReCET that delivers gentle electric pulses to the first part of the small intestine. The goal is to trigger cell regeneration and improve blood sugar control in people with type 2 diabetes who are not on insulin. Participants are randomly assigned…

This study tests a new drug called daraxonrasib in people with pancreatic cancer who have already had surgery and chemotherapy. The goal is to see if taking the drug can delay or prevent the cancer from returning compared to just watching and waiting. About 500 adults will be ran…

This early-stage trial is testing a new experimental medicine called NNC1679-0001 for type 2 diabetes. Researchers want to see if it is safe and how well the body tolerates it. The study includes both healthy volunteers and people with type 2 diabetes, who will receive either a s…

This phase 2 trial tests whether a series of procedures to remove cancerous tumors, given one after another, can improve outcomes for people with stage IV foregut cancers (like stomach, pancreas, or bile duct cancer) who have no detectable cancer DNA in their blood after initial …

This early-phase study tests a new drug, LY3962673, in people with advanced solid tumors that have a specific KRAS G12D mutation, including pancreatic, lung, and colorectal cancers. The main goals are to check safety and see if the drug shrinks tumors, given alone or with chemoth…

This study tests an experimental oral drug called S241656 (BDTX-4933) in people with advanced solid tumors that have certain genetic changes (KRAS, BRAF, or other RAS/MAPK mutations). The trial has two parts: first, finding a safe dose, then testing how well it works alone or wit…

This study tests whether adding the drug relacorilant to standard chemotherapy can help people with metastatic pancreatic cancer live longer without their disease getting worse. About 60 adults who have not yet been treated for advanced pancreatic cancer will receive the combinat…

This Phase 2 trial tests a drug called rezpegaldesleukin in people recently diagnosed with type 1 diabetes (within 100 days). The goal is to see if it can help the body keep producing some insulin, reducing the need for injected insulin. 66 participants will receive either the dr…

This Phase 3 trial tests a new drug called KAI-9531, given as a weekly injection, in 1700 adults who are overweight or obese and have type 2 diabetes. The study compares KAI-9531 to a placebo to see if it leads to greater weight loss and better blood sugar control over 76 weeks. …

This study compares two digital approaches—live video classes and simple text messages—against traditional in-person classes to help 150 Hispanic/Latino adults with type 2 diabetes better manage their condition. The goal is to see if these digital tools can improve blood sugar co…

This early-stage trial is testing a new radioactive drug (177Lu-DFC413) to see if it is safe and can shrink tumors in people with advanced solid cancers like pancreatic, lung, breast, colorectal, and sarcoma. About 180 adults whose cancer has progressed after standard treatments …

This early-stage trial tests a new drug called LY4052031, which is designed to deliver a cancer-killing agent directly to tumor cells that have a protein called Nectin-4. The study includes 420 adults with advanced or metastatic solid tumors such as bladder, breast, lung, and oth…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors that have high levels of a protein called mesothelin, including mesothelioma. Participants' own immune cells are collected, modified in a lab to better attack cancer, and then gi…

This study tests two higher doses (3.0 mg and 4.5 mg) of the diabetes drug dulaglutide in teenagers aged 10 to 17 with type 2 diabetes. The goal is to see if these doses are safe and help control blood sugar and weight. Participants will receive weekly injections for about 8 mont…

This study tests a new drug, LY4170156, designed to attack cancer cells with a specific marker (folate receptor alpha). It is for people with advanced solid tumors like ovarian, lung, or breast cancer that have not responded to other treatments. The trial has two parts: first fin…

This trial compares two types of keyhole surgery to remove the tail of the pancreas. One uses a dye called indocyanine green that glows under special lights, helping surgeons see blood flow and decide where to cut. The other is the standard procedure without the dye. The goal is …

This study tests whether a special anti-inflammatory diet can lower inflammation and improve blood sugar control in people with type 2 diabetes. 88 adults will be randomly assigned to either the anti-inflammatory diet or standard diabetes dietary advice for 4 weeks. Researchers w…

This study tests whether peer coaching can help older adults (55+) with uncontrolled type 2 diabetes in rural Kentucky better manage their condition. Participants are paired with trained peer coaches who call them weekly or bi-weekly to discuss self-care and goals. The study will…

This phase 2 trial tests clofutriben, a drug that lowers cortisol, in 1500 adults with hard-to-control type 2 diabetes and signs of high cortisol. Participants receive either clofutriben or a placebo daily for 24 weeks. The study measures changes in blood sugar and cortisol level…

This study tests if leg exercise (like pedaling) is better than arm exercise for controlling blood sugar, weight, and stress in pregnant women with gestational diabetes. 108 women in their second trimester will exercise three times a week for eight weeks. The goal is to find a sa…

This study tests a combination of two drugs, pembrolizumab and olaparib, in people with advanced pancreatic cancer that has spread to other parts of the body. To join, participants must have tumors with high mutation levels or specific DNA repair problems. The goal is to see if t…

This study tests whether regular phone calls from a trained peer coach can help older adults (55+) with type 2 diabetes in rural Kentucky improve their self-care. Participants are divided into groups that receive weekly or bi-weekly coaching calls to discuss goal-setting and diab…

This study tests a new treatment for adults with certain cancers (pancreatic, kidney, breast, melanoma, or ovarian) that have a protein called CD70. Doctors take a sample of your blood, modify your white blood cells in a lab to recognize and attack CD70, and then give them back t…

This study tests an experimental oral medication, KAI-7535, taken once daily to help people with obesity or overweight lose weight. About 320 adults with at least one weight-related condition (like high blood pressure or sleep apnea) will receive either the drug or a placebo for …

This study tests a new drug called AZD4360 in adults with advanced solid tumours that have a specific marker (CLDN18.2). The drug is an antibody-drug conjugate designed to deliver a toxic payload directly to cancer cells. The trial aims to find the safest dose and see if it shrin…

This study tests a new treatment called EGFR FPBMC for people with advanced pancreatic cancer that cannot be removed by surgery or has spread. The treatment uses a patient's own immune cells, which are modified in the lab to better attack cancer cells, then given back through an …

This study tests a new device that delivers a special type of radiation directly into pancreatic tumors. The goal is to see if it's safe and possible to place these tiny seeds in people with advanced pancreatic cancer that can't be removed by surgery. The study will enroll 15 par…

This study tests a new approach for teens (ages 10-17) recently diagnosed with type 1 diabetes. They will use an inhaled insulin called Afrezza along with a long-acting injected insulin. The goal is to see if this combination helps keep blood sugar in a healthy range and is safe …

This study tests a new daily pill, icovamenib, for people with type 2 diabetes who still have high blood sugar despite taking Ozempic. About 60 adults will receive either the pill or a placebo for 12 weeks. The main goal is to see if the pill lowers HbA1c (a measure of blood suga…

This study looks at whether THC, the active part of marijuana, can change how the body handles sugar and affects blood vessel health in people with type 2 diabetes. About 30 adults will take THC or a placebo for two weeks, then have their blood sugar and blood vessel function tes…

This study compares a continuous glucose monitor (CGM) to standard fingerstick testing in 270 adults with type 1 or type 2 diabetes who use insulin injections. Participants wear the Accu-Chek SmartGuide sensor to track blood sugar levels continuously. The goal is to see if the CG…

This early-phase trial tests an experimental drug called ES502 in people with advanced pancreatic cancer that has a specific genetic change (RAS G12V) and who have run out of standard treatments. ES502 is a lab-made protein designed to guide the body's immune T-cells to attack ca…

This study tests a new device that delivers a special type of radiation directly into pancreatic tumors. It is for people with advanced pancreatic cancer that cannot be removed by surgery. The main goals are to see if the procedure is safe and possible to do. About 15 participant…

This study tests a new device called DaRT that delivers a special type of radiation directly into pancreatic tumors. It is being combined with standard chemotherapy in 30 people with advanced or metastatic pancreatic cancer. The main goal is to see if the combination is safe, and…

This study is testing an education program for people with type 2 diabetes who also have chronic kidney disease. The program provides patients with information about their kidney health and suggests medications that could slow kidney damage. Researchers will see if this approach …

This study tests whether adding an experimental drug called zoldonrasib to standard chemotherapy helps people with a specific genetic form of metastatic pancreatic cancer (KRAS G12D mutation) live longer without their cancer growing. About 670 adults with advanced pancreatic canc…

This study tests whether a 12-week sleep-focused behavioral program can help adults with type 1 diabetes improve their sleep and blood sugar control. Participants learn sleep hygiene, stress management, and routines to target 7-9 hours of quality sleep. The study tracks sleep wit…

This early-phase study tests a new combination treatment for people with advanced pancreatic cancer that has spread or cannot be removed by surgery. The treatment uses specially engineered immune cells (NK cells) from donated cord blood, given through a belly infusion and a vein,…

This early-phase trial tests a new drug called ASP2138, which helps the immune system attack cancer cells that have a specific marker (CLDN18.2). It is for people with advanced stomach, gastroesophageal junction (GEJ), or pancreatic cancer that cannot be removed by surgery or has…

This early-phase trial is testing a new treatment called MEM-288, a virus designed to infect and kill cancer cells while also boosting the immune system. The study involves 40 adults with advanced solid tumors, including lung, skin, and breast cancers, who have not responded to s…

This study tests a single dose of a new drug, ALN-4324, to see if it improves how the body uses insulin in people with type 2 diabetes. About 40 adults who are on a stable dose of metformin will take part. The main goal is to measure changes in insulin sensitivity using a glucose…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 is made from a patient's own immune cells, which are …

This study tests a drug called M3814 combined with a special type of radiation for people with locally advanced pancreatic cancer (cancer that has spread nearby but not to distant organs). The goal is to find the safest dose and see if the combination helps stop tumor growth long…

This early-phase study tests an experimental drug called OKN4395, taken as a pill, alone or together with the immunotherapy pembrolizumab. The goal is to find a safe dose and see if the combination can shrink tumors in people with advanced solid cancers like lung, colorectal, sto…

This early-stage study tests an experimental drug called ALN-4324 in two groups: healthy overweight volunteers and overweight patients with type 2 diabetes. The goal is to check the drug's safety and how well it controls blood sugar. Participants receive either the drug or a plac…

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This early study tests a new catheter system that delivers the chemotherapy drug Gemcitabine directly into or near pancreatic tumors. It includes 9 patients with advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this approach is safe and feasible…

This study tests an experimental drug called HRS-7058 in people with advanced pancreatic cancer that has a specific mutation in the KRAS gene (G12C). Participants must have already tried at least one prior treatment. The goal is to see if the drug can shrink tumors and how safe i…

This study is testing a new robotic system that uses just one small incision to perform surgeries on the liver, pancreas, stomach, and esophagus. The goal is to see if this single-port approach is safe and works well for these complex operations. The study will enroll 35 adults w…

This early-phase study tests a new drug called CT-95 in people with advanced cancers that have a protein called mesothelin on their cells. The main goals are to find a safe dose and see if the drug can shrink tumors. About 70 adults with ovarian, lung, pancreatic, or other mesoth…

This study tests a new treatment using a patient's own immune cells, called CAR T cells, that are specially designed to target and kill solid tumor cells while leaving healthy cells unharmed. It is for adults with certain advanced cancers, including lung, colon, pancreatic, ovari…

This early-phase study tests a new radioactive drug called NRT6008, given alongside standard chemotherapy, for people with advanced pancreatic cancer that cannot be removed by surgery or has spread to nearby lymph nodes. The trial will enroll 58 adults to find the safest dose and…

This early-stage trial tests a new drug called M7437 in people with advanced solid tumors that have not responded to standard treatments. M7437 is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells that have a specific marker (Ly6E). The study ai…

This Phase 2 trial tests a combination of two immunotherapy drugs, odetiglucan and mitazalimab, as a maintenance treatment for people with unresectable pancreatic cancer that has not worsened after 4-8 months of standard chemotherapy. The study will enroll 100 adults and measure …

This study will test if a 'produce prescription' program, called Eat Well, helps veterans with high blood pressure and food insecurity. About 1,500 veterans in North Carolina will either get money for fruits and vegetables for 6 or 12 months, or standard care. Researchers will tr…

This early-stage trial is testing a new drug called THE-0504 in 30 adults with advanced solid tumors, including lung, colon, stomach, breast, and pancreatic cancers. The main goal is to see if the drug is safe and to find the best dose. Researchers will also watch for any signs t…

This pilot study is testing whether combining cognitive behavioral therapy (CBT) with guided exercise can improve blood sugar control, reduce depression, and boost quality of life in Black men with type 2 diabetes. Eighty participants will receive 8 sessions of CBT, with half als…

This early-phase trial tests an oral drug called ALTA3263 in about 448 adults with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a KRAS mutation. The main goals are to check safety, find the right dose, and see how the body processes the drug. Part…

This study tests a new drug called INV-8989 in people with advanced solid tumors that have a specific genetic change called KRAS G12D. The trial has two phases: the first finds the safest dose, and the second checks how well the drug shrinks tumors. About 178 adults with cancers …

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to standard care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device for 13 weeks or continue their usual routine. The goal is to see if the devic…

This Phase 2 trial tests whether adding a personalized cancer vaccine (autogene cevumeran) and an immunotherapy drug (atezolizumab) to standard chemotherapy (mFOLFIRINOX) can keep pancreatic cancer from coming back after surgery. About 260 people whose tumors were completely remo…

This study tests a new combination of drugs for people with advanced pancreatic cancer that has spread or come back. The treatment includes an experimental antibody (BMS-986340) plus immunotherapy and two chemotherapy drugs. The goal is to see if this mix is safe and shrinks tumo…

This study tests a drug called teplizumab in people aged 1 to 25 who were recently diagnosed with type 1 diabetes. The goal is to see if teplizumab can help control blood sugar and reduce the need for insulin at mealtimes. Participants will receive either teplizumab or a placebo …

This phase 2 trial tests whether giving a powerful chemotherapy regimen called NALIRIFOX along with targeted radiation and the drug capecitabine can shrink pancreatic tumors enough to allow successful surgery. The study enrolls 60 people with borderline resectable or locally adva…

This early-phase trial is testing an experimental drug called CX-5461 (Pidnarulex) in people with advanced solid tumors (pancreatic, prostate, breast, or ovarian) that have specific BRCA2 or PALB2 gene mutations. The main goal is to find a safe and tolerable dose for future studi…

This study tests a digital tool that helps children under 12 with type 1 diabetes calculate their insulin doses. The tool considers factors like carbs, blood sugar levels, and trends. Researchers will compare blood sugar control (HbA1c) over 6 months between kids using the tool p…

This early-phase trial tests whether adding pegcetacoplan to standard chemotherapy (mFOLFIRINOX) is safe and effective for people with metastatic pancreatic cancer. Pegcetacoplan targets part of the immune system to possibly slow tumor growth and reduce blood clots, a common comp…

This study is checking if a new insulin pump (NMX8) and continuous glucose monitor (DS5/Simplera Sync) are safe for people with type 1 or type 2 diabetes. About 400 participants, ages 7 to 85, will first wear the sensor for up to 40 days, then use the pump for about 90 days while…

This study tests whether a program called Sisters for Heart Health can help farmworker women ages 18-50 reduce stress, feel less isolated, and improve their heart health. Participants will join weekly peer support groups led by trained community health workers for 10 weeks. The s…

This early-stage trial tests a new therapy that takes a patient's own immune T-cells, engineers them to recognize and attack pancreatic cancer cells with specific KRAS mutations, and infuses them back. The study includes 96 adults with advanced pancreatic cancer who have the righ…

This phase 2 trial tests whether adding the immunotherapy drug cemiplimab to standard chemotherapy gemcitabine can help people with a certain genetic type of advanced pancreatic cancer live longer. The study enrolls 43 adults whose cancer has spread and who have already tried one…

This phase 2 trial tests a drug called zanidatamab in about 200 adults with advanced HER2-positive cancers, including breast, lung, stomach, and others. Participants have already tried at least one standard treatment. The study measures how many tumors shrink or disappear. Zanida…

This early-stage trial tests a new drug called KO-2806, alone or with other cancer drugs, in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find safe doses and check for early signs of tumor shrinkage. About 300 participants wi…

This early-phase study tests whether dichloroacetate (DCA), a drug used safely for decades in a rare metabolic disorder, can improve brain function during low blood sugar (hypoglycemia) in people with type 1 diabetes. Sixteen participants with a history of severe hypoglycemia or …

This early-phase study tests a new gene therapy for people with pancreatic cancer that has returned after standard treatment. The therapy uses a patient's own immune cells, modified to target a protein called B7-H3 on cancer cells, and includes a safety switch to control side eff…

This early-stage study tests an experimental oral drug called ONO-3310 in healthy Japanese men and in people with type 2 diabetes who also have chronic kidney disease. The main goal is to check the drug's safety and how the body processes it. Researchers will also measure its eff…

This early-phase trial tests a new radioactive drug called RYZ401 in people with neuroendocrine tumors and other solid tumors that have a specific protein on their surface. The drug delivers a powerful radioactive particle directly to cancer cells. The study aims to find the safe…

This early-stage study is testing a new insulin pill (SCD0503) in 16 men with type 1 diabetes. The goal is to see how well the pill works compared to standard injected insulin and whether it is safe. Participants will have their blood sugar carefully controlled during the study t…

This study tests whether a continuous glucose monitor (CGM) can improve pregnancy outcomes for women with gestational diabetes compared to standard finger-prick testing. About 386 women from Belgium and Australia will be randomly assigned to use either a CGM or a regular glucomet…

This phase 3 trial tests whether adding radiotherapy to standard chemotherapy after pancreatic cancer surgery can prevent the cancer from coming back. It enrolls 288 high-risk patients who have had surgery but still have factors like positive margins or lymph node involvement. Pa…

This study tests whether adding the drug BMS-986504 to standard chemotherapy can help control pancreatic cancer in people with a specific genetic change (MTAP deletion). About 60 adults with this type of pancreatic cancer will receive the combination before and after surgery or w…

This study tests whether a special nutritional supplement, designed using artificial intelligence, can help adults with type 2 diabetes lower their blood sugar over 24 weeks. One hundred participants will receive either the active supplement or a placebo, alongside their usual di…

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This early-stage study tests a new type of cancer vaccine made from irradiated tumor and nearby cells. It aims to see if the vaccine is safe and can help the immune system fight advanced solid tumors like osteosarcoma, pancreatic cancer, and others. About 54 people will take part…

This study tests whether regularly screening for diabetes-related emotional distress and offering support can improve blood sugar control in adults with type 2 diabetes. About 1,250 participants with high blood sugar (A1C over 8%) will take part. The goal is to see if addressing …

This study tests an experimental drug called BLU-924 (SAR449336) in people with advanced pancreatic, lung, or colorectal cancers that have specific KRAS mutations. The drug is designed to block the cancer-driving KRAS protein. The trial will enroll about 265 participants to evalu…

This early-phase study tests a new radioactive drug, LY4337713, in people with advanced cancers that have high levels of a protein called FAP. The cancers include certain types of ovarian, breast, pancreatic, colorectal, esophageal, stomach, and bile duct cancers. The study aims …

This study tests a new drug that delivers a tiny dose of radiation directly to cancer cells that have a specific marker called FAP. The trial involves 112 adults with advanced cancers of the pancreas, stomach, esophagus, colon, ovary, head/neck, sarcoma, or mesothelioma. First, a…

This early-phase trial tests a new drug called MRG007 (ARR-217) in people with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and check if the drug can shrink tumors. About 405 participants with colorectal, gastric, or pan…

This early-stage trial tests a new drug called NNC0497-0040 in healthy people, those with overweight or obesity, and people with type 1 diabetes who are also overweight. The goal is to see if the drug is safe and tolerable when given as a weekly injection. About 146 participants …

This program provides the experimental drug ulixertinib to people with advanced solid tumors that have certain gene mutations (MAPK pathway). It is for patients who have not responded well to or have run out of standard treatments. The goal is to control the disease and possibly …

This early-stage trial tests a new drug called PHN-012 in people with advanced colon, pancreatic, or lung cancer that has stopped responding to standard treatments. The drug is an antibody-drug conjugate, designed to deliver a powerful cancer-killing agent directly to tumor cells…

This study looks at whether adding menopausal hormone therapy to a GLP-1 drug (semaglutide) improves blood sugar control in early postmenopausal women who have or are at risk for type 2 diabetes. About 96 women with menopausal symptoms and a BMI of 27 or higher will be enrolled. …

This study tests if a new insulin that is injected just once a week works as well as daily insulin shots to control blood sugar in people with type 2 diabetes. About 586 adults who have never used insulin before will take either the weekly insulin or a standard daily insulin for …

This early-phase trial is testing a new type of cell therapy for people with advanced pancreatic cancer that has spread or cannot be removed by surgery. The treatment uses specially engineered natural killer (NK) cells that target two proteins found on cancer cells. Up to 42 part…

This study tests whether adding tivozanib (a drug that targets blood vessel growth) to atezolizumab (an immunotherapy) can help the immune system attack cancers that normally resist immunotherapy. The trial includes people with several cancer types like bile duct, pancreatic, pro…

This Phase 2 trial tests an oral drug called BAY 2927088 (sevabertinib) in about 111 adults with advanced solid tumors that have HER2 gene mutations. The drug aims to block the abnormal HER2 protein and stop cancer growth. Participants take a 20 mg tablet daily in 3-week cycles u…

This study is tracking 145 adults with type 2 diabetes in Argentina who are starting semaglutide (either as a pill or injection) as part of their normal care. Researchers will measure changes in blood sugar, weight, waist size, and grip strength over 12 months, along with how sat…

This study tests whether combining two experimental drugs, MET233 and MET097, can help adults with obesity or overweight lose weight, including those with type 2 diabetes. About 381 participants will receive either the drug combination or a placebo to check safety and how well th…

This early-phase study tests a new drug called BBO-11818 in people with advanced cancers that have a KRAS mutation, including lung, pancreatic, and colorectal cancers. The main goals are to check safety and find the best dose, while also seeing if the drug can shrink tumors. Abou…

This early-phase trial is testing a new oral drug called RMC-5127, alone or combined with other drugs, in adults with advanced solid tumors that have a specific KRAS G12V mutation. The study includes people with lung, colorectal, and pancreatic cancers who have already tried stan…

This early-stage study tests a new drug, WVE-007, given as a shot under the skin to help with weight loss. It includes about 296 adults who are overweight or have obesity, some with pre-diabetes or type 2 diabetes. The main goal is to check safety and how the drug moves through t…

This study tests a new medicine, EYP-1901, given as an eye injection to people with diabetic macular edema (DME), a condition that causes blurry vision in people with diabetes. The goal is to see if EYP-1901 works as well as the standard treatment (aflibercept) but with fewer inj…

This study tests whether walking at least 10,000 steps a day and avoiding snacks after 8 p.m. can improve metabolic health in teenagers aged 12-18 with prediabetes. Eighty participants will be randomly assigned to either the lifestyle program or standard care for 8 weeks. The mai…

This phase 3 trial tests EYP-1901, a new eye injection, against the standard treatment aflibercept for diabetic macular edema (DME), a condition that causes vision loss in people with diabetes. The study will enroll 240 participants and compare how well each drug improves vision …

This study tests a once-weekly injection called NNC0487-0111 in 630 adults who are overweight or obese and have type 2 diabetes. Participants receive either the active drug or a placebo for about a year. The main goal is to see how much weight they lose, with additional checks on…

This early-phase trial tests a new drug called AVA6103 in 174 people with advanced solid tumors (like pancreatic, stomach, or lung cancer) that have not responded to standard treatments. The drug is designed to activate only inside tumors, potentially killing cancer cells while r…

This phase 2 trial is testing a new drug combination for people with advanced pancreatic cancer that has a specific mutation called KRAS G12D. The treatment combines HRS-4642 (a drug that targets the mutated protein), nimotuzumab (an antibody that blocks a growth signal), and sta…

This study tests a drug called CM4620 in children and young adults who develop pancreatitis (inflammation of the pancreas) from a chemotherapy drug called asparaginase. The goal is to see if CM4620 is safe and can prevent severe complications like pancreatic cysts or tissue death…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This study tests an experimental pill called cadisegliatin taken alongside insulin in adults with type 1 diabetes. The goal is to see if it can lower the number of dangerously low blood sugar events (hypoglycemia) without worsening overall blood sugar control. About 150 participa…

This study tests whether a continuous glucose monitor (CGM) helps control blood sugar better than standard finger-stick checks for people with diabetes who are recovering at home through Mayo Clinic's Advanced Care at Home program. About 100 participants will use the Dexcom G6 PR…

This study tests whether a drug called chiglitazar, combined with anti-inflammatory and liver-protecting therapies, can improve liver health in people who have both MASH (a severe fatty liver disease) and type 2 diabetes. About 300 adults will receive either the drug combo or a p…

This study is testing a new tool called MODI, which is a smart algorithm that helps people with diabetes figure out the right amount of insulin to take. About 100 adults with type 1 or type 2 diabetes will use the MODI system along with a continuous glucose monitor for 13 weeks. …

This phase 2 study tests a new drug called IBI343 combined with two chemotherapy drugs (gemcitabine and nab-paclitaxel) in people with advanced stomach, gastroesophageal junction, or pancreatic cancers that have a specific protein (CLDN18.2). The goal is to see if the combination…

This study looks at whether adding support from a pharmacist or a community health worker helps adults with type 2 diabetes better manage their blood sugar. About 376 people will be placed into one of four groups: usual care, pharmacist help, community health worker help, or both…

This study tests whether giving a low dose of anti-thymocyte globulin (ATG) followed by either adalimumab or verapamil can help preserve the body's ability to make insulin in people aged 9 to under 21 who were recently diagnosed with type 1 diabetes. The main goal is to see if th…

This early-phase trial tests a new way to deliver chemotherapy directly to the lining of the abdomen in people with pancreatic cancer that has spread there. The treatment, called PIPAC, uses a spray of chemotherapy drugs under pressure to reach tumor spots more effectively. The s…

This study tests an experimental drug called RMC-9805, taken as a pill, in adults with advanced solid tumors (such as lung, colorectal, or pancreatic cancer) that have a specific mutation in the KRAS gene called G12D. The drug is given alone or in combination with another oral dr…

This study investigates whether continuous glucose monitor (CGM) data can pinpoint the time of day when a person with prediabetes experiences the largest blood sugar spikes after eating. Participants wear a CGM and activity tracker for 10 days to identify their personal 'vulnerab…

This study tests an experimental drug called AZD9574, taken alone or with other anti-cancer medicines, in about 695 people whose advanced solid tumors have grown despite prior treatment. The main goals are to check the drug's safety and find the right dose. Researchers will also …

This study is testing whether semaglutide, a drug already used for type 2 diabetes, can reduce kidney damage in people with type 1 diabetes and diabetic kidney disease. About 60 adults will receive either semaglutide or a placebo for 26 weeks. Researchers will measure changes in …

This study tests a new therapy where a person's own white blood cells are collected, genetically modified in a lab to recognize and attack cancer cells with a specific mutation (KRAS G12V), and then infused back. Participants also receive chemotherapy and a drug to boost cell act…

This program offers a personalized vaccine called PCNAT-01 to patients with pancreatic cancer who have had surgery and finished chemotherapy. The vaccine is made from each patient's unique tumor proteins and is given as shots to train the immune system to fight any remaining canc…

This early-phase study tests a new drug called CT3001 in people with advanced solid tumors (like colorectal or pancreatic cancer) that have stopped responding to standard treatments. The study has two parts: first, finding a safe dose of CT3001 alone, then testing it combined wit…

This early-stage study tests an experimental drug called MK-1403 in people with type 2 diabetes. The main goals are to check if the drug is safe and tolerable, and to see how it behaves in the body. Researchers will also measure its effect on a marker of inflammation (hsCRP). Abo…

This study is testing a gel that turns into a gel when warmed, used alongside standard gum disease treatment. It includes 70 adults, some with type 2 diabetes and some without, to see if the gel helps gums heal better and if healing differs between the two groups. Participants wi…

This study tests whether a special high-protein shake can help overweight or obese adults with type 2 diabetes preserve lean muscle mass when they start taking GLP-1 drugs like Ozempic or Mounjaro. About 60 participants will be randomly assigned to drink the shake or follow stand…

This study tests whether dapagliflozin, a diabetes medication, can slow or reverse plaque buildup in the heart arteries of people with type 2 diabetes. About 144 adults with stable heart disease will take either the drug plus standard care or standard care alone for 18 months. Re…

This study tests a procedure that uses a thin, flexible tube with a camera and ultrasound to guide a needle into pancreatic cysts. Chemotherapy drugs are injected directly into the cyst to shrink or destroy precancerous cells. The goal is to prevent these cysts from developing in…

This study tests whether using an AI-driven retinal camera during regular diabetes checkups can increase the number of young people screened for diabetic retinopathy, a leading cause of blindness. Researchers will enroll 500 youth with type 1, type 2, or cystic fibrosis-related d…

This study is testing a new blood test called EXoPred that uses artificial intelligence and laser technology to find tiny particles from cancer cells. The goal is to detect breast, colon, pancreatic, ovarian, and lung cancers at an early stage. Researchers will enroll 1,400 peopl…

This study is testing whether a new blood test can screen for many types of cancer at once. Researchers will enroll 24,000 adults aged 45-75 who do not have cancer. Participants will be randomly assigned to one of two blood test groups or a control group. The goal is to see how w…

This phase 3 trial is testing a new type of PET scan that uses a radioactive tracer called [18F]FAPI-74 to detect whether pancreatic cancer has spread to other parts of the body. About 200 adults with pancreatic cancer will receive one dose of the tracer and then be scanned. The …

This early-phase study is testing two radioactive imaging agents, 68Ga-DFC413 and 68Ga-NNS309, to see how well they highlight tumors on PET scans. About 66 adults with advanced pancreatic, lung, breast, colorectal, or soft tissue cancers will receive the agents. The goal is to co…

This study is testing a new blood test called Enzeavour that looks for tiny signs of pancreatic cancer in healthy people. About 10,000 adults in Japan getting routine checkups will give a blood sample. If the test shows a high score, they will get further imaging to check for can…

This study looks for early signs of pancreatic cancer in fluid from pancreatic cysts. Researchers will measure specific molecules in the fluid to see if they can accurately tell which cysts are cancerous. The goal is to develop a less invasive test than current methods, helping c…

This study is testing a blood test that looks for tiny bits of cancer DNA (ctDNA) in people with esophageal, gastric, or pancreatic cancer. The goal is to see if it can find signs of cancer coming back or getting worse earlier than current methods. About 34 participants will give…

This study tests a new radioactive tracer called [18F]FPyQCP for PET scans to see if it can better detect several cancers, including colorectal, ovarian, gastric, breast, and pancreatic. About 71 adults with these cancers will receive the tracer and have a PET/CT scan. The goal i…

This study looks for new ways to diagnose pancreatic cancer, a disease that is often caught too late. Researchers will analyze fluid that is normally thrown away after a standard biopsy procedure. They hope to find proteins or other molecules that could lead to a simple blood tes…

LiverSeek is a study testing an automated screening program for advanced liver fibrosis in people aged 50-75 with risk factors like diabetes or obesity. When a routine blood test is done, the lab system automatically calculates a fibrosis score and, if needed, orders additional t…

This study compares two blood test methods for detecting circulating tumor cells (CTCs) that express a protein called Axl, which is linked to more aggressive cancer. The new technique, called EPIDROP, is being tested against the standard CellSearch method in patients with metasta…

This study is testing a new laser-based blood test that uses nanoparticles to detect pancreatic cancer early. Researchers will enroll 400 people, including those with diabetes, pancreatic cysts, or pancreatic cancer, to see if the test can accurately identify cancer. The goal is …

This study tests a new PET/CT scan using a radioactive tracer called GEH300079 to detect peritoneal carcinomatosis—cancer that has spread to the lining of the abdomen—in people with colorectal, stomach, ovarian, or pancreatic cancer. About 175 adults with known or suspected sprea…

This study tests whether a device that shines light through the toe (photoplethysmography) can quickly detect peripheral artery disease in people with diabetes. The new method measures how long it takes blood to refill the toe after a heartbeat, and researchers compare it to the …

This study tests whether a new ultrasound technique called SMI can accurately identify benign pancreatic cysts (serous cystadenomas). Currently, many patients with these harmless cysts undergo unnecessary surgery due to diagnostic uncertainty. The study will enroll 60 patients an…

This study tests whether a high-powered imaging technique called ultra-high resolution optical coherence tomography (OCT) can detect tiny, early-stage pancreatic cancers in tissue samples removed during surgery. Researchers will compare OCT images with standard lab analysis and a…

This study is testing a new, non-invasive liver scan called iLivTouch to see if it can accurately detect a serious liver condition called MASH in people who have both type 2 diabetes and fatty liver disease. The scan measures liver inflammation, fat, and stiffness without any nee…

This study tests a new type of PET/CT scan (using [68Ga]Ga-FAPI-46) to see if it can find and stage gastroesophageal and pancreatic cancers better than current scans. About 90 adults with these cancers will get the new scan before surgery or treatment, and some will have a second…

This study tests a dye called CYTALUX (pafolacianine) that attaches to cancer cells and glows under a special camera during surgery. About 50 adults with certain cancers (like esophageal, pancreatic, or gynecologic) will get the dye before surgery. The goal is to see if the glowi…

This study collects breath samples from 235 people with type 2 diabetes or obesity to improve a device that estimates blood sugar from exhaled air. Participants breathe into a portable analyzer that measures volatile organic compounds. The goal is to gather data to refine the dev…

This study aims to see if adding simple blood tests and symptom reviews to standard screening can catch pancreatic cancer earlier in people with a high genetic risk. Researchers will enroll 5,000 participants who have certain gene mutations linked to pancreatic cancer. The goal i…

This study is testing a new real-time continuous glucose monitoring (CGM) system to see how accurate and safe it is for adults with type 1 diabetes. About 82 participants will wear the device, and its readings will be compared to standard lab measurements. The goal is to improve …

This pilot study is testing whether eating fermented poi every day for four weeks can improve the gut health of pregnant women and lower their risk of developing gestational diabetes. Fifty pregnant women between 10 and 24 weeks will eat one pound of poi daily and receive nutriti…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This pilot study tests whether a family-centered health and wellness coaching program can help prevent type 2 diabetes in South Asian and Black African/Caribbean families in Ontario, Canada. Each family dyad includes an adult caregiver and a youth aged 14–24. Participants receive…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests whether screening women for type 2 diabetes while they are still in the hospital after giving birth can help catch the disease early and prevent it. About 116 women who had gestational diabetes will be randomly assigned to either early testing or usual care. The …

This study is testing whether a digital tool that encourages self-reflection and healthy habits can prevent type 2 diabetes. Over 40,000 adults without diabetes will use the app or receive usual care for three years. Researchers will track how many people develop diabetes in each…

This study tests whether the drug baricitinib can delay the onset of type 1 diabetes in children aged 1 to 36 months who are at high risk. Participants take baricitinib or a placebo daily for up to 5 years. The goal is to see if the drug can push back or prevent the need for insu…

This study tests a 3-year lifestyle program for 1,305 Brazilian adults at high risk for type 2 diabetes. The program combines in-person and online counseling on diet, exercise, sleep, and stress. Researchers will track who develops diabetes and measure weight, blood sugar, and qu…

This study tests a family-oriented version of the Diabetes Prevention Program for Black families in Southwest Georgia. Parents with prediabetes and their children aged 8-15 will learn healthy eating and exercise habits together. The goal is to help parents lose weight and lower t…

This study is testing whether a special software that analyzes CT scans of the heart's arteries can better prevent heart attacks, strokes, and other cardiovascular events compared to usual care based on risk factors like cholesterol and blood pressure. The trial will enroll 7,500…

This study tests whether a natural bile acid called 7-Ketolithocholic Acid, taken as a supplement, can lower blood sugar levels in 100 adults with prediabetes. Participants will also follow a healthy diet and exercise plan. The goal is to see if this supplement can help prevent o…

This study compares two rectal non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and diclofenac, to see which one better prevents pancreatitis after an ERCP procedure. About 4050 adults aged 18-90 with an intact papilla will be randomly assigned to receive one of the d…

This study tests whether rinsing the bile duct opening with cold water, in addition to standard rectal indomethacin, can better prevent pancreatitis after ERCP—a common procedure to treat bile or pancreas issues. About 150 adults in India will be randomly assigned to get either t…

This study looks at whether adding brewer's spent grain (a beer-making byproduct) to cookies can help control blood sugar after eating. Twenty healthy adults will eat regular cookies and special high-fiber cookies on different days, and their blood sugar will be checked over two …

This study tests if special sensor-equipped insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. About 400 high-risk participants will use the insoles alongside standard care or just standard care alone. The goal is to see if the insoles…

This study tests whether giving adults at risk for type 2 diabetes free fresh fruits and vegetables, along with a proven lifestyle program, can help them lower blood sugar and lose weight. One hundred adults with prediabetes will either get the standard diabetes prevention progra…

This study tests whether the drug semaglutide can prevent type 2 diabetes in women who had gestational diabetes and now have high blood sugar after pregnancy. About 252 women will receive either semaglutide or a placebo for several months. The goal is to see if the drug lowers th…

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This study will test whether giving women with gestational diabetes a home ultrasound device, guided remotely by a doctor, improves their satisfaction and health outcomes compared to standard care. About 90 participants will use the device for fetal checks from home. The goal is …

This study tests a drug called ponsegromab combined with standard chemotherapy to see if it helps adults with advanced pancreatic cancer who are losing weight and appetite (cachexia). About 982 participants will receive either ponsegromab or a placebo alongside their first chemot…

This study looks at whether the timing of a 9-hour eating window (early, mid, or late in the day) affects blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Over 7 days, 120 participants will follow one of three time-restricted eating schedule…

This study tests whether ear acupuncture, led by village doctors and supported by telemedicine, can improve sleep in adults aged 65 and older who have both diabetes and high blood pressure. Participants will receive either real or sham ear acupuncture for 6 weeks. The goal is to …

This study tests whether the drug sonlicromanol can reduce fatigue and improve physical abilities like balance and leg strength in adults with a specific genetic form of mitochondrial disease. About 220 participants will take either the drug or a placebo twice daily for 52 weeks.…

This Phase 2 trial tests whether KL1333 can reduce fatigue and improve leg strength in adults with primary mitochondrial disease, a genetic condition that affects energy production. About 180 participants will receive either KL1333 or a placebo twice daily for 48 weeks. The study…

This pilot study tests whether a 36-session targeted exercise program can help frail pancreatic cancer patients stay stronger and complete their chemotherapy with fewer problems. Researchers will enroll 25 patients who are frail or pre-frail and receiving chemotherapy before surg…

This Phase 3 trial tests whether the experimental drug paltusotine can reduce flushing and diarrhea in adults with carcinoid syndrome caused by neuroendocrine tumors. About 141 participants will receive either paltusotine or a placebo daily for 12 weeks. The study measures how mu…

This study compares two types of nerve blocks—coeliac plexus block and splanchnic nerve block—to see which one reduces pain better in adults with upper abdominal cancer. Forty-four participants will receive one of the procedures and be monitored for pain, opioid use, and quality …

This pilot study is testing whether a virtual reality (VR) cognitive training program can help protect memory and thinking skills in adults aged 45-80 with type 2 diabetes and mild cognitive impairment. Forty participants will be randomly assigned to either 16 weeks of VR-based t…

This study tests whether the Thrive AI Health app can help adults with type 2 diabetes or overweight improve their daily habits like diet, exercise, and sleep. About 20 participants will either use the app or not, and researchers will compare changes over time. The app uses artif…

This trial tests a web-based program called COMPASS that provides personalized exercise and nutrition advice, along with text messages, activity trackers, and coaching, for people with stage I-III pancreatic cancer receiving chemotherapy before surgery. The goal is to see if the …

This pilot study tests whether a new, faster radiation planning method can safely ease severe abdominal pain caused by advanced cancer. Instead of a separate planning session, doctors use existing scans to create a treatment plan on the spot. Only 5 people will take part, and the…

This study tests whether a 16-week hydration program can reduce side effects like nausea and dehydration in people starting GLP-1 medications (such as Ozempic or Wegovy). Researchers will track 30 adults aged 18-60 who recently started the drug, measuring hydration levels and sid…

This study tests whether a 6-month course of pancrelipase (CREON) can improve digestive symptoms in people who have exocrine pancreatic insufficiency (EPI) after an acute pancreatitis attack. About 30 adults with confirmed EPI and moderate-to-severe symptoms will take the enzyme …

This study tests whether taking omega-3 fish oil capsules and doing simple resistance exercises with elastic bands can help cancer patients maintain muscle mass and strength. It involves 288 adults with various cancers who are at risk of muscle wasting. The goal is to improve phy…

This early-stage trial tests a new drug called GB18 in 18-36 cancer patients who are losing weight and appetite due to their illness (cachexia). The drug is given as a shot under the skin. The main goal is to check safety, but researchers will also see if it helps patients gain w…

This study tests whether pairing teens with type 1 diabetes with a young adult peer mentor can help them become more physically active and improve their quality of life. The 12-week program includes in-person, virtual, and text-based support. Researchers will measure how well the…

This study tests a quicker method of giving radiation therapy to ease severe abdominal pain caused by pancreatic cancer. Normally, preparing for this treatment takes a week or more because a special planning CT scan is needed. Here, doctors will use the patient's existing diagnos…

This study tests a group-based program called Supporting Teen Problem Solving (STePS) designed to reduce diabetes-specific emotional distress in teenagers with type 1 diabetes. The program is based on cognitive-behavioral and problem-solving approaches. Researchers will enroll 36…

This study compares a psychological therapy program called ACT1VATE to standard diabetes education in 250 adults with type 1 diabetes who have high emotional distress and poor blood sugar control. The therapy is delivered in five group sessions via video call. Researchers will me…

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study follows 600 Indigenous families in Manitoba to understand how maternal health, genetics, and early-life environment contribute to obesity and type 2 diabetes in children. Pregnant women with type 2 diabetes, gestational diabetes, or no diabetes are enrolled, and their …

This study aims to learn how type 2 diabetes and obesity in young people affect heart and blood vessel health over time. About 930 participants aged 12 to 25, including those with diabetes, overweight but not diabetic, and healthy lean individuals, will be followed for up to 25 y…

This study aims to collect blood, urine, tumor samples, and health data from up to 1,000 people with malignant mesothelioma or other cancers that express a protein called mesothelin. Participants will be followed over time to track the course of their disease. The goal is to buil…

This study enrolls people with endocrine tumors (such as thyroid, parathyroid, adrenal, or pancreatic tumors) who are scheduled for surgery or biopsy. Researchers collect samples of the tumor, nearby healthy tissue, blood, and urine to analyze genetic and molecular changes. The g…

This study explores whether stem cells from taste buds can be turned into insulin-making cells. Researchers will take tiny tissue samples from the tongues of 250 healthy adults to isolate and grow these stem cells in a lab. The goal is to see if this is possible in humans, which …

This study investigates how two days of forearm immobilization (keeping the arm in a cast or sling) changes the way muscles take up glucose and amino acids. Researchers will compare these effects in people with type 2 diabetes and healthy volunteers. The goal is to understand why…

This study aims to learn more about insulin resistance and diabetes by collecting blood and skin samples from up to 1,200 participants, including patients with severe insulin resistance and their family members. Researchers will study genetics and how insulin works in the body to…

This observational study looks at whether combining CT scans, blood tests, and pathology reports can more accurately predict how pancreatic cancer will progress. Researchers will collect existing medical records from about 1,030 participants who had surgery for pancreatic cancer.…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

This early-stage study tests the safety of a new drug called AZD4248 in healthy volunteers and people with chronic kidney disease and type 2 diabetes. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. …

This study looks at 100 people who have had a Whipple procedure (pancreaticoduodenectomy) for cancers of the pancreas or nearby areas. The goal is to find factors before, during, and after surgery that raise the risk of a pancreatic fistula—a leak of digestive fluid that can caus…

This study investigates how muscle fiber type and protein makeup relate to early insulin resistance, a key step before type 2 diabetes develops. Researchers will follow 250 healthy adults aged 20-30 for up to 20 years, using muscle biopsies, scans, and wearable sensors. The goal …

This study looks at how your genes and your environment—like what you eat, breathe, and experience—work together to influence common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires, genetic data, and other information from 25…

This study looks at how improving sleep regularity might help control blood sugar and reduce heart disease risk in adults with type 1 diabetes. Researchers will monitor 100 participants' sleep, blood sugar, and heart health markers. The goal is to understand the body clock's role…

This study investigates whether 6 weeks of treadmill walking with blood flow restriction cuffs on the legs can improve immune cell function in adults with type 2 diabetes. Participants walk three times per week, with some wearing inflatable cuffs that partially limit blood flow. …

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment affect her child's growth and risk for obesity, diabetes, and fatty liver. Mothers attend visits during pregnancy and after birth, while c…

This study looks at basic blood and clotting measures in children with type 1 diabetes compared to healthy children. Researchers want to see if diabetes causes changes in red blood cells or clotting that could lead to complications. The study involves children aged 1 month to 18 …

This study at the National Institutes of Health is looking at 1,000 adults with known or suspected hormone gland (endocrine) disorders. The goal is to better understand these conditions and help train doctors. Participants may receive tests, treatments, or surgery as part of thei…

This study looks at how ongoing stress, anxiety, and poor sleep might affect the course of pancreatic cancer. Researchers will ask 320 participants to fill out simple questionnaires about their mental well-being and will also measure stress markers in leftover blood samples. The …

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study explores the link between sleep duration and blood sugar control in adolescents aged 12-20 with type 2 diabetes. Researchers will first measure sleep and blood sugar in 67 teens, then test a program using Fitbits and text messages to encourage longer sleep in 15 teens …

This study is gathering health information from 2,000 adults with primary sclerosing cholangitis (PSC) to build a real-world data comparator group. The goal is to help design and run future drug trials more efficiently by providing a control group from real patient experiences. P…

This study follows people who previously took part in type 1 diabetes trials to see how long their bodies continue to produce insulin. Researchers will also look at how immune system changes relate to insulin production. The goal is to gather information that could lead to better…

This study will follow 500 adults with chronic kidney disease and type 2 diabetes who are taking finerenone, a drug that helps protect the kidneys and heart. Researchers want to see if a tool called the Klinrisk score, which estimates the risk of kidney disease getting worse, imp…

This research study follows 500 adolescents with type 2 diabetes to understand why some develop kidney problems. Researchers are looking at biological factors like blood sugar and blood pressure, as well as psychological and social factors such as stress, mental health, and pover…

This study is testing whether growing a patient's tumor cells in the lab (as 3D 'organoids') can help doctors pick the best drug for advanced cancers that have stopped responding to standard treatments. About 152 adults with colorectal or pancreatic cancer will have a biopsy to c…

This study looks at why people with pancreatic cancer often lose muscle and weight (cachexia). Researchers will collect blood, tissue, and imaging data from 500 patients to understand the biology and build an AI model that could warn doctors early. It is an observational study, s…

This study follows 2,800 unpaid caregivers of people with chronic conditions like diabetes or inherited disorders. Researchers will survey and interview caregivers over up to 5 years to track changes in their health, stress, and social support. The goal is to understand how careg…

This study is tracking 20,000 people who have a family history of pancreatic cancer or carry genes that raise their risk. Researchers hope to find better ways to detect the disease early, when it's more treatable. Participants will be followed over time to see who develops pancre…

This study is looking for biological markers (biomarkers) in blood, saliva, and urine that signal damage to insulin-producing beta cells in the pancreas. Researchers will compare samples from people with type 1 diabetes, type 2 diabetes, prediabetes, and healthy volunteers. The g…

This study tests a digital app called the Genetics Adviser for Mainstream Care (GA-Mainstream) that educates cancer patients about genetic testing and delivers their results. Researchers want to see if using the app reduces distress and improves the patient experience compared to…

This study is checking if the diabetes medicine exenatide (Byetta, Bydureon) increases the risk of pancreatic cancer. Researchers will look at health records from 24,000 patients across seven European countries, comparing those who started exenatide with those who started other d…

This study looks at whether CFTR modulators (ETI) help control blood sugar in people with cystic fibrosis-related diabetes (CFRD). Researchers will compare 30 adults with CFRD who take ETI to those who cannot take it. The goal is to see if the drug improves how the body handles s…

This study is testing a new device that combines an insulin pump with a continuous glucose monitor in one unit for adults with type 1 diabetes. The goal is to see how insulin delivery near the sensor affects glucose readings and to gather data to improve the design. About 40 part…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study tests a program called SPARK-CGM that helps primary care clinics prescribe continuous glucose monitors (CGM) to people with diabetes. CGM devices track blood sugar in real-time, but they are underused in primary care. The program provides training, workflow support, an…

This study aims to better understand why some people experience dangerously low blood sugar (hypoglycemia), especially after fasting. Researchers will admit 1,500 adults to the NIH Clinical Center for controlled fasting and a series of blood tests to measure insulin and other fac…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study is analyzing tissue and blood samples from 64 people with pancreatic cancer that has spread. Researchers want to understand how cancer cells change their energy use and interact with surrounding cells. The goal is to find new targets for treatment and better ways to pr…

This study from Mayo Clinic looks at how one session of exercise changes breastmilk. Researchers will measure tiny particles called exosomes that carry messages between cells. They want to see if exercise boosts these particles in breastmilk, which might help prevent childhood ob…

This trial is studying a medical device that has not been approved by the U.S. FDA. The purpose and specific details are not publicly available. It likely involves a small group of participants to gather initial safety or effectiveness data.

This study will give 100 adults with diabetes a thermal camera that attaches to their smartphone to take daily pictures of their feet. The goal is to collect temperature data and see if hot spots can predict where foot ulcers might form. Participants will use the device at home f…

This study looks at how a 12-week lifestyle change affects inflammation and stress markers in 60 overweight adults with type 2 diabetes and moderate chronic kidney disease. Participants will follow a modified diet and exercise plan. The goal is to see if these changes can reduce …

This study is testing a new technique called EXPEL to find biomarkers for pancreatic cancer. Researchers will analyze the fluid used to preserve biopsy samples from 200 patients with suspected pancreatic cancer. The goal is to identify proteins and other molecules that could help…

This study aims to discover new genes that may cause certain cancers to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had cancer, especially childhood cancers. The goal is to build a regist…

This study aims to find out why people with diabetes often have lower vitamin C levels in their blood. Researchers will measure vitamin C in blood, urine, and cells from 5,000 adults with and without diabetes. They will also look at genes that control vitamin C transport. The goa…

This study collects tissue samples from people with solid tumors who are already scheduled for surgery or biopsy at the NIH Clinical Center. Researchers will use the samples to study the biology of cancer and identify new targets for therapy. Up to 1,800 adults and children (age …

This study compares two ways of monitoring pancreatic cysts—more frequent versus less frequent scans—and looks for biomarkers in the blood that might help predict cancer risk. About 770 adults aged 50 to 75 with at least one cyst will take part. The goal is to find out which moni…

This study looks at tiny particles called extracellular vesicles (EVs) released from fat cells. Researchers want to understand how these particles carry signals that may affect heart and liver health in people with obesity. About 100 adults having weight-loss surgery will provide…

This study looks at how fat buildup in the pancreas contributes to type 2 diabetes and whether weight loss can reverse it. Researchers will follow 104 overweight adults, including those without diabetes, with prediabetes, and with short- or long-term diabetes. Participants will f…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can help predict how well pancreatic cancer patients respond to chemotherapy. Researchers will track ctDNA levels before, during, and after treatment in 500 patients whose cancer has not spread. The goal …

This observational study will follow 50,000 people in Asia and the United States who have chronic kidney disease and type 2 diabetes and are already taking finerenone as part of their regular care. Researchers will collect data from electronic health records and insurance claims …

This study reviews medical records of 400 adults aged 40-70 who were recently diagnosed with type 2 diabetes in five Southeast Asian countries. Researchers will look at health data from before and after diagnosis to understand how heart disease risk is distributed. No new treatme…

This study reviews medical records from 3,000 patients who had emergency surgery at a Swedish hospital between 2009 and 2019. Researchers want to understand what factors increase risks and how patients fare in the long run, including complications, repeat surgeries, and survival.…

This trial investigates whether a lidocaine infusion given during pancreatic cancer surgery can affect circulating tumor cells (CTCs) — cancer cells that may travel through the blood. Researchers will compare lidocaine to a saline placebo in patients undergoing robotic pancreatec…

This study is testing whether mixed reality (using a Meta Quest 3 headset) can reliably measure walking ability, balance, and leg strength in people with type 2 diabetes. Researchers will compare the digital versions of three common physical tests (6-minute walk, timed up and go,…

This study aims to safely collect health information like heart rate and activity levels from cancer patients using devices like smartphones and wearables. Researchers will use this data to learn more about how it relates to cancer diagnosis, treatment response, and risk factors.…

This study investigates whether the unique bacteria found inside digestive system tumors can help predict how well a patient will respond to neoadjuvant therapy (chemotherapy before surgery). Researchers will analyze tumor samples from 90 adults with pancreatic, gastric, colorect…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study looks at whether sending home test kits or ordering standard lab tests can help more people with type 2 diabetes get screened for chronic kidney disease (CKD). About 750 adults who are missing key kidney function tests will be enrolled. The goal is to see if these appr…

This observational study is gathering detailed metabolic data from 25 adults with insulin-dependent type 2 diabetes. After drinking a standard liquid meal, participants will have frequent blood tests to measure glucose, insulin, and other markers. They will also wear continuous g…

This study watches 500 adults in South Korea who have chronic kidney disease and type 2 diabetes and are taking finerenone as part of their normal care. Researchers will collect information from medical records and doctor visits over up to 12 months to see why doctors prescribe i…

This study looks at how blood sugar changes day-to-day in people with ketosis-prone diabetes as they go into remission. Researchers will use this data to build a math model that describes the remission process. The study involves 12 African American adults with a BMI of 28 or hig…

This study looks at how menstrual cycles and birth control pills impact blood sugar levels and exercise in women with type 1 diabetes. Researchers will monitor 150 women for three months using continuous glucose monitors and offer personalized insulin and diet adjustments. The go…

This study is collecting health data from 1,500 adults with diabetes in Switzerland to see how well current treatments work in everyday life. Researchers will track complications, quality of life, and survival over time. The goal is to find out what's working and what needs impro…

This study looks at how an FDA-approved diabetes drug, Canagliflozin (Invokana), might protect the kidneys in people with type 2 diabetes. Twenty adults aged 18-80 with type 2 diabetes for at least 3 years will take the drug daily for 6 months. Researchers will use kidney biopsie…

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study is collecting detailed genetic and health information from 500 people with various cancers, including breast, lung, and leukemia. The goal is to create a shared database that helps researchers develop more personalized treatments. Participants provide samples and data,…

This study reviews medical records of 500 adults treated for benign or malignant pancreatic diseases since 2005. The goal is to understand how well different treatments worked over time. No new treatments are given—just careful analysis of past cases.

This study tests a smartphone app designed to help adults taking GLP-1 medications for obesity or type 2 diabetes eat better. About 50 participants will use the app for 6 weeks to track their diet and learn about nutrition. The goal is to see if the app is helpful and easy to use…

This study looks at how accurate continuous glucose monitors (CGMs) are in children and young adults with type 1 diabetes when they have surgery. Researchers will compare CGM readings to standard blood glucose tests during the procedure. The goal is to see if these devices can be…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…

This study looks at ways to increase genetic testing for people with breast, pancreatic, or colorectal cancer. Researchers will try different methods—like training doctors, giving feedback, and improving electronic health records—to see what helps oncology teams order more tests.…

This study explores whether a special MRI technique called 3D-MRE can measure the stiffness of pancreatic tumors to help predict how the disease will progress. Researchers will enroll 200 adults with pancreatic cancer and compare imaging results with actual tumor hardness and tre…

This study follows 30 people aged 16–80 with obesity who are starting weight-loss medication. Researchers will track changes in hunger, fullness, cravings, and portion size using questionnaires and interviews at 0, 3, 12, and 18 months. The goal is to understand how eating behavi…

This study looks at whether using a continuous glucose monitor and a Fitbit activity tracker can help people aged 55 and older with type 2 diabetes sit less and control their blood sugar better. Researchers will track how often participants respond to prompts to stand up and how …

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This study looks at whether drinking 200 ml of water two hours before a planned C-section changes stomach volume differently in pregnant women with diabetes compared to those without. Researchers will use ultrasound to measure stomach contents before and after drinking. The goal …

This study is testing whether a mobile app called Fabla-diabetesMM, which lets people record audio diaries, is easy and helpful for older adults with type 1 or 2 diabetes who also have other health conditions. Thirty participants will use the app and answer questions about their …

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study looks at how social factors and health literacy affect the ability of people with diabetes to manage their own care. Researchers will survey 400 adults with type 1 or type 2 diabetes to understand these connections. The goal is to design better support programs that he…

This study is a registry that will follow 50 adults who are already scheduled to receive EUS-guided radiofrequency or microwave ablation for pancreatic or other gastrointestinal lesions as part of their routine care. Researchers will collect data from medical records to see how t…

This study looks at why wounds heal slowly or not at all in people with diabetes. Researchers will collect blood and wound fluid from 250 adults with chronic wounds to compare immune cells between diabetic and non-diabetic participants. The goal is to understand the biological re…

This study is testing whether wearable devices like continuous glucose monitors and smart bracelets, combined with smartphone apps, can help predict and prevent complications in people with type 2 diabetes. Researchers will enroll 6,000 adults and follow them for 3 months, using …

This study aims to find pancreatic cancer earlier in people who are at higher-than-average risk due to family history or genetic mutations. Researchers will collect blood samples and health data from 30,000 participants over time to build a biobank. The goal is to improve early d…

This study looks at whether improving sleep and circadian timing can reduce heart disease risk in adolescents with type 1 diabetes who typically sleep less than 7 hours per night. Fifty teens will follow a one-month program that includes a longer sleep schedule, a low dose of mel…

This study tests whether a low-added-sugar, high-fat diet can reduce diabetes risk in adults with cystic fibrosis (CF). Sixty participants will receive either a low-sugar or standard CF diet for 8 weeks. Researchers will measure changes in insulin production, body fat, and blood …

This study looks at whether a genetic risk score can predict which people with newly diagnosed diabetes will eventually need insulin. Researchers will follow about 3,000 patients aged 14 to 50 for up to 3 years, tracking their C-peptide levels (a marker of insulin production) and…

This study follows 140 pregnant women who conceived while still breastfeeding. Researchers want to see if breastfeeding lowers the chance of developing gestational diabetes in the new pregnancy. They will track blood sugar levels and baby growth to find out.

This study tests whether a mobile app called MyCap can help track the time patients spend on pancreatic cancer treatment, including appointments, travel, and waiting. Thirty adults with pancreatic cancer who are on active treatment will use the app daily for 8 weeks. The goal is …

This observational study collects tumor tissue and blood cells from 200 people with advanced solid tumors like colorectal, lung, and pancreatic cancers. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for potential fu…

This study uses a special microscope called intravital microscopy to look at blood vessels inside solid tumors while patients are in surgery. Researchers want to see how these vessels work and how well they let blood and dye flow through. The goal is to learn whether tumor vessel…

This study looks at whether treating gestational diabetes early (before 24 weeks) is better than waiting until the standard 24-28 week screening. About 2,010 pregnant women with mild early high blood sugar will be randomly assigned to either start intensive treatment right away o…

This study is looking at whether GLP-1 receptor agonists—drugs used for type 2 diabetes and obesity—can also improve dry eye disease. Researchers will measure changes in tear stability and eye surface health in 100 patients who have not taken these drugs before. The goal is to un…

This early-stage study looks at how the body processes HRS9531 injection in people with mild or moderate liver issues compared to those with healthy livers. Researchers will measure drug levels and check for side effects in 24 participants. The goal is to understand if liver func…

This study is testing whether a smartphone-based program that provides high-fiber foods and continuous glucose monitors can help young adults (ages 18-39) with prediabetes improve their blood sugar control. The main goal is to see if people find the program easy to use and stick …

This study looks at how certain immune cells, called meta-inflammatory monocytes, along with body composition and diet, may contribute to insulin resistance in adolescents. Researchers will collect blood samples and health information from 175 teens aged 14-18, including those wi…

This study tests whether giving doctors a geriatric assessment—a quick check of frailty and function—helps them set safer blood sugar goals for patients aged 60+ with type 2 diabetes. 220 participants will be randomly assigned to usual care or to have their doctor receive the ass…