New combo therapy aims to boost radiation for tough pancreatic tumors

NCT ID NCT07157033

Recruiting now Disease control Sponsor: Xerient Pharma Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests a drug called XER-001 (a form of amifostine given through a tube into the small intestine) combined with precise radiation therapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The study will enroll 36 participants to find the safest dose and check for early signs of tumor control. The main goal is to see if the combination is safe and tolerable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: XER-001 (amifostine delivered via a tube from the nose to the small intestine)
What this could lead to: If it works, this could point toward a way to make radiation therapy safer and more effective for people with locally advanced pancreatic cancer.
What could go wrong: This is a very early, small trial (36 people) focused on safety and finding the right dose. It may not show clear benefit, and side effects from the drug or radiation are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic adenocarcinoma pancreatic ductal adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED PANCREAS CANCER LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA LOCALLY ADVANCED PANCREATIC DUCTAL ADENOCARCINOMA

Contacts and locations

Locations

CIty of Hope
RECRUITING

Irvine, California, 92618, United States
Christus St. Vincent Regional Cancer Center
RECRUITING

Santa Fe, New Mexico, 87505, United States
City of Hope
RECRUITING

Duarte, California, 91010, United States
Oncology Consultants, P.A.
RECRUITING

Houston, Texas, 77030, United States

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