Four-Drug cocktail aims to shrink pancreatic tumors before surgery

This phase II trial tests whether a combination of four chemotherapy drugs—paclitaxel protein bound, gemcitabine, cisplatin, and hydroxychloroquine—given before surgery can improve outcomes for people with pancreatic cancer that has not spread. The study focuses on patients whose tumors are removable, borderline removable, or locally advanced. The main goal is to see if the treatment normalizes a key tumor marker called CA 19-9, which may indicate better surgical results.