Triple threat against pancreatic cancer: radiation, immunotherapy, and chemotherapy combined
NCT ID NCT07683221
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This phase 2 trial tests a new treatment approach for people with locally advanced pancreatic cancer that cannot be removed by surgery. Participants receive targeted radiation therapy followed by a combination of two immunotherapy drugs (ipilimumab N01 and sintilimab) plus standard chemotherapy (nab-paclitaxel and gemcitabine). The goal is to see if this powerful mix can delay cancer growth and improve survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Stereotactic body radiotherapy, ipilimumab N01, sintilimab, nab-paclitaxel, gemcitabine
- What this could lead to
- If successful, this combination approach could offer a new treatment option that extends survival and controls tumor growth in patients with locally advanced pancreatic cancer.
- What could go wrong
- This is an early-phase, single-arm trial with only 47 participants, so results may not apply broadly. The combination of therapies may cause significant side effects, and the treatment may not improve outcomes compared to standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Shandong Cancer Hospital and Institute
Jinan, Shandong, 0531, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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