New drug combo targets Hard-to-Treat cancers in early trial

NCT ID NCT07446855

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 4 times

Summary

This study tests a new drug called AZD4956, alone or with other cancer drugs, in people with advanced or spreading solid tumors that have a specific DNA repair defect (HRR deficiency). The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. About 180 adults with few other options will take part in this early-phase trial.

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Conditions

The condition(s) this trial relates to.

breast cancer castration-resistant prostate carcinoma DNA repair disease fallopian tube cancer malignant pancreatic neoplasm ovarian cancer primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMOURS

Contacts and locations

Locations

Research Site
RECRUITING

New York, New York, 10065, United States
Research Site
NOT_YET_RECRUITING

Providence, Rhode Island, 02903, United States
Research Site
RECRUITING

Houston, Texas, 77030, United States
Research Site
RECRUITING

Fairfax, Virginia, 22031, United States
Research Site
RECRUITING

Melbourne, 3000, Australia
Research Site
NOT_YET_RECRUITING

Westmead, 2145, Australia
Research Site
NOT_YET_RECRUITING

Chūōku, 104-0045, Japan
Research Site
RECRUITING

Kashiwa, 277-8577, Japan
Research Site
NOT_YET_RECRUITING

Seoul, 03080, South Korea
Research Site
NOT_YET_RECRUITING

Seoul, 120-752, South Korea
Research Site
NOT_YET_RECRUITING

Barcelona, 08023, Spain
Research Site
NOT_YET_RECRUITING

Barcelona, 08036, Spain
Research Site
NOT_YET_RECRUITING

Barcelona, 8035, Spain
Research Site
NOT_YET_RECRUITING

Logroño, 26006, Spain
Research Site
NOT_YET_RECRUITING

Pozuelo de Alarcón, 28223, Spain
Research Site
NOT_YET_RECRUITING

Seville, 41013, Spain
Research Site
NOT_YET_RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Research Site
NOT_YET_RECRUITING

London, SE1 9RT, United Kingdom
Research Site
NOT_YET_RECRUITING

Sutton, SM25PT, United Kingdom

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