Exocrine pancreatic insufficiency

This study tests a new medicine called ANG003 for people with cystic fibrosis who have trouble digesting food (exocrine pancreatic insufficiency). The medicine is a type of enzyme replacement therapy, similar to the current standard treatment Creon. About 113 participants will re…

This study tests whether a weekly injection of dulaglutide, a GLP-1 drug used for diabetes, can improve early insulin release in adults with cystic fibrosis who have trouble processing sugar. About 30 participants will receive the drug or no drug in a crossover design. The goal i…

This study tests a device called RELiZORB that adds digestive enzymes directly to liquid food given through a feeding tube. It is for people who have trouble digesting food after pancreatitis. The goal is to see if it improves symptoms and quality of life. About 60 adults will ta…

This phase 3 trial tests whether taking pancreatic enzyme capsules can help people who have lost significant weight after a severe bout of pancreatitis. The study will enroll 140 adults with more than 50% pancreatic damage and at least 5% weight loss. Participants will receive ei…

This study tests a drug called dorzagliatin in 15 adults with cystic fibrosis who have trouble controlling their blood sugar. Participants take the drug or a placebo for 7 days each, in a crossover design. The goal is to see if dorzagliatin improves glucose tolerance and insulin …

This study is testing whether taking pancreatic enzyme supplements (Creon) can improve blood sugar control and digestive function in people with chronic pancreatitis who have trouble digesting food. Researchers will monitor 80 participants over time to see how their glucose level…

This study tests a new blood test (Malabsorption Blood Test, or MBT) to find mild-to-moderate pancreatic insufficiency in people with chronic or recurrent acute pancreatitis. A small group of participants who respond to pancreatic enzyme replacement therapy (PERT) will then be ra…

This study tests whether a 6-month course of pancrelipase (CREON) can improve digestive symptoms in people who have exocrine pancreatic insufficiency (EPI) after an acute pancreatitis attack. About 30 adults with confirmed EPI and moderate-to-severe symptoms will take the enzyme …

This study tests a special medical food powder (Encala®) in 18 adults with pancreatic cancer who have trouble absorbing fat, causing stomach issues and weight loss. The goal is to see if the powder is easy to take and helps improve fat absorption and quality of life. This is an e…

This study at the National Institutes of Health is looking at 1,000 adults with known or suspected hormone gland (endocrine) disorders. The goal is to better understand these conditions and help train doctors. Participants may receive tests, treatments, or surgery as part of thei…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study reviews medical records of 500 adults treated for benign or malignant pancreatic diseases since 2005. The goal is to understand how well different treatments worked over time. No new treatments are given—just careful analysis of past cases.

This study enrolls adults with known or suspected endocrine (hormone gland) disorders, such as diabetes or thyroid disease, to help researchers learn more about these conditions. Participants will undergo medical exams, blood and imaging tests, and possibly genetic testing. The m…

This study aims to collect and analyze pancreatic fluid from 24 healthy adults after giving them a synthetic hormone called secretin. The secretin is injected during an endoscopic ultrasound to stimulate the pancreas to release fluid, which is then collected from the duodenum. Re…

This observational study will examine how the pancreas works in 310 adults with type 2 diabetes. Researchers will use blood tests, stool samples, and ultrasound to measure both hormone and digestive functions. The goal is to identify a different form of diabetes called pancreatog…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study aims to understand why many people with cystic fibrosis develop diabetes. Researchers will give two gut hormones, GLP-1 and GIP, to 45 adults with cystic fibrosis and measure how their pancreas releases insulin. The goal is to learn more about cystic fibrosis-related d…

This study tracks 1,000 patients undergoing major liver, pancreas, or bile duct surgery to see if the time it takes for their albumin levels to return to normal can predict complications and length of hospital stay. Albumin is a protein that drops after surgery due to inflammatio…