New enzyme pill could help cystic fibrosis patients digest food better

NCT ID NCT07450547

Recruiting now Disease control Sponsor: Anagram Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 12 times

Summary

This study tests a new medicine called ANG003 for people with cystic fibrosis who have trouble digesting food (exocrine pancreatic insufficiency). The medicine is a type of enzyme replacement therapy, similar to the current standard treatment Creon. About 113 participants will receive either ANG003 or Creon to see if the new treatment is safe and works as well. The main goal is to measure how well the body absorbs fat and to check for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ANG003 (a pancreatic enzyme replacement therapy)
What this could lead to: If it works, this could offer a new treatment option for people with cystic fibrosis who have trouble digesting food due to pancreatic insufficiency.
What could go wrong: This is an early Phase 2 trial with only 113 participants, so results may not apply to everyone. The new therapy might not work better than the current standard treatment, Creon.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cystic fibrosis exocrine pancreatic insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTIC FIBROSIS (CF) EXOCRINE PANCREATIC INSUFFICIENCY (EPI)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Adult Cystic Fibrosis Center at the University of Utah
NOT_YET_RECRUITING

Salt Lake City, Utah, 84112, United States
Boston Children's Hospita
NOT_YET_RECRUITING

Boston, Massachusetts, 02115, United States
Center for Cystic Fibrosis at Keck Medical Center of USC
NOT_YET_RECRUITING

Los Angeles, California, 90033, United States
Central Florida Pulmonary Group
NOT_YET_RECRUITING

Orlando, Florida, 32803, United States
Children's Hospital Medical Center of Akron
RECRUITING

Akron, Ohio, 44308, United States
Froedtert & Medical College of Wisconsin
NOT_YET_RECRUITING

Milwaukee, Wisconsin, 53226, United States
Hershey Medical Center Pennsylvania State University
RECRUITING

Hershey, Pennsylvania, 17033, United States
Long Beach Memorial Medical Center
RECRUITING

Long Beach, California, 90806, United States
MaineHealth Pediatric Specialty Care
NOT_YET_RECRUITING

Portland, Maine, 04102, United States
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
National Jewish Health
RECRUITING

Denver, Colorado, 80206, United States
Nationwide Children's Hospital, Columbus
NOT_YET_RECRUITING

Columbus, Ohio, 43205, United States
New York Medical College at Westchester Medical Center
NOT_YET_RECRUITING

Valhalla, New York, 10595, United States
Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center
NOT_YET_RECRUITING

Cleveland, Ohio, 44106, United States

Contact Email: •••••@•••••
Rutgers - Robert Wood Johnson Medical School
RECRUITING

New Brunswick, New Jersey, 08903, United States
The Cystic Fibrosis Institute
RECRUITING

Glenview, Illinois, 60025, United States
Toledo Children's Hospital
RECRUITING

Toledo, Ohio, 43606, United States
University of Florida
NOT_YET_RECRUITING

Gainesville, Florida, 32610, United States
University of Iowa
NOT_YET_RECRUITING

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center
NOT_YET_RECRUITING

Kansas City, Kansas, 66160, United States
University of Kentucky
RECRUITING

Lexington, Kentucky, 40506, United States
University of Michigan, Michigan Medicine
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Pittsburgh Medical Center
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
University of Texas Southwestern / Children's Health
RECRUITING

Dallas, Texas, 75207, United States
University of Wisconsin
RECRUITING

Madison, Wisconsin, 53792, United States
Wayne State University Harper University Hospital
NOT_YET_RECRUITING

Detroit, Michigan, 48201, United States

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