New enzyme pill could help cystic fibrosis patients digest food better
NCT ID NCT07450547
First seen Jun 25, 2026 · Last updated Jun 30, 2026 · Updated 3 times
Summary
This study tests a new medicine called ANG003 for people with cystic fibrosis who have trouble digesting food (exocrine pancreatic insufficiency). The medicine is a type of enzyme replacement therapy, similar to the current standard treatment Creon. About 113 participants will receive either ANG003 or Creon to see if the new treatment is safe and works as well. The main goal is to measure how well the body absorbs fat and to check for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ANG003 (a pancreatic enzyme replacement therapy)
What this could lead to
If it works, this could offer a new treatment option for people with cystic fibrosis who have trouble digesting food due to pancreatic insufficiency.
What could go wrong
This is an early Phase 2 trial with only 113 participants, so results may not apply to everyone. The new therapy might not work better than the current standard treatment, Creon.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Adult Cystic Fibrosis Center at the University of Utah
NOT_YET_RECRUITINGSalt Lake City, Utah, 84112, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Boston Children's Hospita
NOT_YET_RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Center for Cystic Fibrosis at Keck Medical Center of USC
NOT_YET_RECRUITINGLos Angeles, California, 90033, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Central Florida Pulmonary Group
NOT_YET_RECRUITINGOrlando, Florida, 32803, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital Medical Center of Akron
NOT_YET_RECRUITINGAkron, Ohio, 44308, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Froedtert & Medical College of Wisconsin
NOT_YET_RECRUITINGMilwaukee, Wisconsin, 53226, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hershey Medical Center Pennsylvania State University
RECRUITINGHershey, Pennsylvania, 17033, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Long Beach Memorial Medical Center
RECRUITINGLong Beach, California, 90806, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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MaineHealth Pediatric Specialty Care
NOT_YET_RECRUITINGPortland, Maine, 04102, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Massachusetts General Hospital
NOT_YET_RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Jewish Health
NOT_YET_RECRUITINGDenver, Colorado, 80206, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nationwide Children's Hospital, Columbus
NOT_YET_RECRUITINGColumbus, Ohio, 43205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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New York Medical College at Westchester Medical Center
NOT_YET_RECRUITINGValhalla, New York, 10595, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center
NOT_YET_RECRUITINGCleveland, Ohio, 44106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rutgers - Robert Wood Johnson Medical School
NOT_YET_RECRUITINGNew Brunswick, New Jersey, 08903, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Cystic Fibrosis Institute
RECRUITINGGlenview, Illinois, 60025, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Toledo Children's Hospital
NOT_YET_RECRUITINGToledo, Ohio, 43606, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Florida
NOT_YET_RECRUITINGGainesville, Florida, 32610, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Iowa
NOT_YET_RECRUITINGIowa City, Iowa, 52242, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kansas Medical Center
NOT_YET_RECRUITINGKansas City, Kansas, 66160, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kentucky
NOT_YET_RECRUITINGLexington, Kentucky, 40506, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Michigan, Michigan Medicine
NOT_YET_RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pittsburgh Medical Center
NOT_YET_RECRUITINGPittsburgh, Pennsylvania, 15224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Texas Southwestern / Children's Health
NOT_YET_RECRUITINGDallas, Texas, 75207, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Wisconsin
RECRUITINGMadison, Wisconsin, 53792, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wayne State University Harper University Hospital
NOT_YET_RECRUITINGDetroit, Michigan, 48201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••