Could modern CF drugs make daily inhaled treatments obsolete?
NCT ID NCT07696338
First seen Jul 10, 2026 · Last updated Jul 10, 2026
Summary
This trial investigates whether children and teens with cystic fibrosis who are already taking highly effective modulator therapy can safely use inhaled airway clearance treatments only when they have a respiratory illness, instead of every day. Participants stop their usual daily hypertonic saline or dornase alfa for a short run-in period, then are randomly assigned to either daily use or as-needed use for one year. The study measures lung function to see if both approaches keep lungs equally healthy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- hypertonic saline and dornase alfa
- What this could lead to
- If successful, this could show that daily inhaled treatments are no longer needed for many children with cystic fibrosis who take modern modulators, reducing treatment burden.
- What could go wrong
- This is a mid-sized trial in children with mild lung disease; results may not apply to those with more severe disease. The study may also find that as-needed use leads to worse lung function over time.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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All Children's Hospital
St. Petersburg, Florida, 33701, United States
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
Contact Email: •••••@•••••
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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CF Centre BC Children's Hospital (Vancouver, Canada)
Vancouver, British Columbia, V6H3V4, Canada
Contact Email: •••••@•••••
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CF Centre Hospital for Sick Children (Toronto, ON)
Toronto, Ontario, M5G1X8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHOC Children's Hospital
Orange, California, 92868, United States
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Children's Healthcare of Atlanta and Emory University
Atlanta, Georgia, 30322, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, 15224, United States
Contact Email: •••••@•••••
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Children's Hospitals and Clinics of Minnesota
Minneapolis, Minnesota, 55404, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Mercy Kansas City
Kansas City, Missouri, 64108, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Wisconsin
Milwaukee, Wisconsin, 53226, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Childrens Hospital Los Angeles
Los Angeles, California, 90027, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Dayton Children's Hospital
Dayton, Ohio, 45404, United States
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John Hopkins Hospital
Baltimore, Maryland, 21287, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
Contact Email: •••••@•••••
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Oregon Health & Sciences University
Portland, Oregon, 97239, United States
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Providence Medical Group, Cystic Fibrosis Clinic - Pediatrics
Spokane, Washington, 99204, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Queen Elizabeth II Hospital Halifax Adult CF Centre
Halifax, Nova Scotia, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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Riley Hospital for Children
Indianapolis, Indiana, 46202, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Louis Children's Hospital
St Louis, Missouri, 63110, United States
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Stanford University Medical Center
Palo Alto, California, 94025, United States
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The Children's Hospital Alabama, University of Alabama at Birmingham
Birmingham, Alabama, 35233, United States
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The Minnesota Cystic Fibrosis Center
Minneapolis, Minnesota, 55455, United States
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Tucson Cystic Fibrosis Center
Tucson, Arizona, 85724, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Michigan, Michigan Medicine
Ann Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599, United States
Contact Email: •••••@•••••
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University of Rochester Medical Center Strong Memorial
Rochester, New York, 14642, United States
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University of Texas Southwestern / Children's Health
Dallas, Texas, 75207, United States
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University of Virginia
Charlottesville, Virginia, 22904, United States
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University of Wisconsin
Madison, Wisconsin, 53792, United States
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Virginia Commonwealth University
Richmond, Virginia, 23219, United States
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Other studies related to the condition(s) this trial covers.
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