CYSTIC FIBROSIS (CF)

This study tests a new medicine called ANG003 for people with cystic fibrosis who have trouble digesting food because their pancreas doesn't work properly. The medicine is a type of enzyme replacement therapy, similar to the standard treatment Creon. The goal is to see if ANG003 …

This study is testing a mobile phone app designed to measure muscle fatigue in people with cystic fibrosis (CF). Researchers want to see if the app, which uses video to analyze a simple sit-to-stand test, is a reliable and valid tool for tracking muscle health. The goal is to pro…

This study tests whether a self-help version of Acceptance and Commitment Therapy (ACT), delivered through a smartphone app, can reduce anxiety and depression in adults with cystic fibrosis. About 60 participants will use the toolkit and report changes in mood, flexibility, and v…

This study looks at whether specific arm and leg exercises can improve muscle strength, breathing, and exercise ability in children with cystic fibrosis. About 22 kids aged 6 to 18 will be randomly assigned to different exercise routines. The goal is to see if targeting upper or …

This study tests a smartphone chatbot called NUDGE that helps teens and young adults with cystic fibrosis (ages 13-25) set and track physical activity goals. The goal is to see if the app keeps them active or gently encourages more movement. The study will enroll 30 people and me…

This study tests a wellness program for adults with cystic fibrosis who feel very tired. The program includes coaching sessions to help improve fatigue, sleep, and physical activity. Researchers will see if people stick with the program and if it helps them feel better compared t…

This study is testing a new app called OnTrackCF to see if it is easy and helpful for adults with cystic fibrosis (CF) to use. About 60 adults with CF who take a twice-daily medication will try the app for several weeks. Researchers will measure how often people use the app and h…

This study looks at whether adults with cystic fibrosis who are on highly effective modulator therapy can safely stop using standard nasal treatments like saline rinses, steroid sprays, and antibiotic washes. Researchers will monitor sinus health, lung function, and quality of li…

This study follows 300 people with cystic fibrosis for a year to learn what triggers sudden lung flare-ups (exacerbations). Participants provide samples and health data; some also undergo extra clinic visits and home monitoring. The goal is to find early warning signs and risk fa…

This study aims to understand why people with cystic fibrosis (CF) often develop kidney disease. Researchers will collect blood and urine samples from 260 participants with CF, both during routine visits and during hospital stays for lung flare-ups, and compare them to samples fr…

This early-stage study tests whether new drug combinations (SION-451 with SION-2222 or SION-109) are safe in healthy adults aged 18-55. It does not involve people with cystic fibrosis yet. The goal is to measure side effects and how the drugs move through the body, laying groundw…

This study tests whether wearable sensors and artificial intelligence can detect changes in the body during a chest infection in adults with cystic fibrosis or bronchiectasis. Researchers will measure things like heart rate and breathing rate before and after a two-week course of…

This study aims to find out how often people with cystic fibrosis-related diabetes (CFRD) develop eye, kidney, and nerve problems, as well as heart disease risks. Researchers will enroll 200 adolescents and adults with CFRD for at least 5 years. The goal is to better understand t…

This study compares children and teens with cystic fibrosis to healthy kids to see how the disease impacts breathing, muscle strength, bladder control, and quality of life. Researchers will measure grip strength, lung function, and other health markers in 50 participants aged 6-1…

This study follows 60 women with cystic fibrosis (CF) who are planning a pregnancy, are pregnant, or have recently given birth. Researchers will track their lung function, nutrition, and mental health, as well as the health of their babies. The goal is to learn what extra care or…

This study aims to validate and check the reproducibility of laboratory tests, equipment, and techniques used in research on chronic diseases like obesity, diabetes, and heart disease. Researchers will compare old and new testing methods to ensure results are accurate and consist…

This study uses MRI scans to see exactly where the drug linaclotide works in the gut. Linaclotide is already used for constipation, but researchers want to know if it could help people with cystic fibrosis, who have trouble with fluid in their gut. Healthy volunteers aged 18-60 w…

This study tests new ways to measure lung function in 60 people with cystic fibrosis. Participants will breathe in a harmless gas (xenon) for a special MRI and do a simple breathing test. The goal is to get a clearer picture of how the lungs change over time, which could help imp…

This study looks at how often people with cystic fibrosis who take the drug combination ETI (Elexacaftor-Tezacaftor-Ivacaftor) have trouble breathing during exercise. Researchers will measure breathing during a 6-minute walk test and a step test. The goal is to understand if thes…

This study tests whether an online education program can help children aged 6-11 with cystic fibrosis and their parents better understand health information. About 104 children and their parents will be split into two groups: one gets the online lessons, the other does not. Resea…

This study is looking at whether germs called NTM that live in home water systems can cause lung infections in people with cystic fibrosis. Researchers will test water, dust, and soil from 120 homes and compare them to germs found in patients. The goal is to understand how people…

This study looks at how the cystic fibrosis drug combination ETI (elexacaftor-tezacaftor-ivacaftor) affects metabolism, gene activity, and gut bacteria in 150 people with CF. Researchers want to understand why some patients develop side effects like high cholesterol or obesity. T…

This study looks at how a Mediterranean diet affects the gut health of children with cystic fibrosis. About 20 kids, ages 3 and older, will follow this diet for 6 months. Researchers will check changes in gut bacteria and inflammation to see if this diet offers better guidance fo…

This study watches 200 people with cystic fibrosis to learn how their bodies respond to standard treatments for severe lung infections. Researchers track symptoms, lung function, and collect samples to understand why some people recover well and others do not. The goal is to use …

This study looks at how the cystic fibrosis drug elexacaftor-tezacaftor-ivacaftor behaves in children aged 2 to 17. Researchers want to understand how drug levels in the blood relate to benefits and side effects. About 150 children with cystic fibrosis who already take this medic…

This study looks at how Alpha-1 Antitrypsin Deficiency and Cystic Fibrosis affect white blood cells in the lungs called macrophages. Researchers will collect blood samples from 220 adults to measure how well these cells work. The goal is to better understand these diseases, not t…