CYSTIC FIBROSIS (CF)

This study tests a new medicine called ANG003 for people with cystic fibrosis who have trouble digesting food (exocrine pancreatic insufficiency). The medicine is a type of enzyme replacement therapy, similar to the current standard treatment Creon. About 113 participants will re…

This early-stage trial tests the safety of three experimental drugs (SION-451, SION-2222, and SION-109) given together to healthy adults aged 18–55. The study aims to see if the combinations are safe and how the body processes them. It is a first step toward possibly developing a…

This study tests a smartphone program called NUDGE that acts like a health coach for teens and young adults (ages 13-25) with cystic fibrosis. Participants set activity goals, track progress, and get feedback through the app. The goal is to see if the app helps them stay active a…

This study tests whether upper and lower limb exercises can improve muscle strength, aerobic capacity, and lung function in children aged 6-18 with cystic fibrosis. Participants will do arm or leg cycling exercises. Researchers will measure changes in walking distance, lung funct…

This study tests whether a self-help version of Acceptance and Commitment Therapy (ACT), delivered via smartphone, can reduce anxiety and depression in adults with cystic fibrosis. About 60 participants will use the toolkit and report their symptoms. The goal is to improve mental…

This pilot study tests a wellness program for adults with cystic fibrosis (CF) to see if it helps with fatigue, sleep, and physical activity. The program includes 8 coaching sessions on topics like balancing activity and rest, improving sleep, and managing stress. Researchers wil…

This study is testing a smartphone app called OnTrackCF, designed to help adults with cystic fibrosis remember to take their CFTR modulator medication and track their symptoms. The app sends up to 3 daily support messages and shows users their adherence levels. Researchers want t…

This study looks at how mucus plugs in the lungs affect breathing in people with severe asthma. Researchers will use special MRI scans to see air flow in blocked areas. Only 5 adults with severe asthma will take part, and the goal is to better understand lung function, not to tes…

This study looks at how the cystic fibrosis drug ETI affects the way the body handles antibiotics. Researchers want to see if people on ETI need lower antibiotic doses to treat lung infections, which could reduce harmful side effects like hearing loss or kidney damage. The study …

This study looks at how new cystic fibrosis drugs work in children ages 2 and older. Researchers want to find genetic clues that can tell us ahead of time who will respond well, so kids don't get unnecessary side effects or high costs from treatments that won't help them. About 1…

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

This study looks at why people with cystic fibrosis often develop kidney disease. Researchers will test blood and urine samples for early signs of kidney damage, comparing CF patients with and without frequent hospital stays, as well as people without CF. The goal is to find bett…

This study looks at whether a Mediterranean diet can improve gut health in children with cystic fibrosis. Twenty kids aged 3 and older will follow this diet for 6 months. Researchers will check changes in gut bacteria and inflammation markers. The goal is to offer better diet adv…

This study looks at how linaclotide, a drug for constipation, affects fluid in the gut. Researchers will use MRI scans to see where the drug works in the small and large intestines. The goal is to learn more about its effects, which could help design future studies for conditions…

This study tests advanced lung imaging (MRI with xenon gas) and breathing tests to better understand lung function in people with cystic fibrosis. 60 participants will be followed over time. The goal is to see if these new methods can detect changes more precisely than standard t…

This study looks at how cystic fibrosis patients who take the drug combination Elexacaftor-Tezacaftor-Ivacaftor (ETI) breathe during exercise. Researchers will measure lung function while patients walk or step, aiming to find out how many have limited breathing capacity. The resu…

This study looks at how cystic fibrosis affects children's breathing, muscle strength, bladder control, and daily life compared to healthy kids. Researchers will measure grip strength, lung function, and other health markers in 50 children aged 6-18. The goal is to identify probl…

This study watches 200 people with cystic fibrosis to learn how their bodies react to standard treatments for severe lung infections. Researchers track symptoms, lung function, and collect samples to understand why some people recover better than others. The goal is to use this k…

This study follows 300 people with cystic fibrosis for one year to learn what triggers sudden worsening of symptoms, called exacerbations. Participants provide regular health data and samples, and some will also have extra clinic visits and home monitoring. The goal is to find ea…

This study looks at how the cystic fibrosis drug combination ETI (elexacaftor-tezacaftor-ivacaftor) behaves in children aged 2 to 17. Researchers will measure drug levels in the blood and see how they relate to the drug's benefits and side effects, such as liver problems or mood …

This study looks at how often people with cystic fibrosis and diabetes develop complications like eye, kidney, and nerve problems. Researchers will also check blood pressure and cholesterol. The goal is to better understand these risks in a diverse group of 200 adolescents and ad…

This study is investigating whether germs called non-tuberculous mycobacteria (NTM) found in home water systems and dust can cause lung infections in people with cystic fibrosis. Researchers will collect samples from the homes of 120 CF patients—some with NTM infections and some …

This study follows 150 cystic fibrosis patients starting the drug combination Trikafta (ETI) to see how it affects their metabolism, DNA methylation, and gut bacteria. Researchers will measure blood fats, sugars, and immune markers, and link them to drug levels. The goal is to un…

This study looks at whether people with cystic fibrosis who are on highly effective modulator therapy can safely stop using nasal saline rinses and steroid sprays. Researchers will monitor sinus health, lung function, and quality of life in 64 adults. The goal is to see if these …

This study is testing whether wearable sensors that track things like heart rate and breathing can detect changes during a chest infection in adults with cystic fibrosis or bronchiectasis. Researchers will monitor 50 patients who are starting intravenous antibiotics for a lung in…

This study from the University of Florida is looking at how two genetic lung conditions—Alpha-1 antitrypsin deficiency and cystic fibrosis—affect immune cells called macrophages. Researchers will collect blood and measure lung function in 220 adults to see how well these cells wo…

This study follows 60 women with cystic fibrosis (CF) who are planning a pregnancy, pregnant, or new parents, along with their babies. Researchers will track lung function, nutrition, mental health, and pregnancy outcomes, as well as infant health issues like liver function and l…