CYSTIC FIBROSIS (CF)

This study aims to understand the broader effects of a powerful cystic fibrosis (CF) drug combination called ETI. Researchers will follow 150 people with CF, including children, who are starting this therapy. They will check how the drug changes metabolism, gut bacteria, and gene…

This study aims to find out if adults with cystic fibrosis who are taking newer, highly effective modulator drugs can safely stop their daily nasal treatments like saline rinses, steroid sprays, and antibiotic drops. Researchers will follow 64 patients for 12 weeks, randomly assi…

This is an early-stage study testing the safety of new drug combinations (SION-451 with SION-2222 or SION-109) for cystic fibrosis. It involves 144 healthy volunteers to see how their bodies react to and process the drugs. The main goal is to find out if the combinations are safe…

This study is testing a smartphone app called NUDGE, which acts like a chatbot coach, to help teens and young adults (ages 13-25) with cystic fibrosis stay or become more physically active. The app helps users set goals, track progress, and get feedback. Researchers want to see i…

This study is testing if adding an experimental drug called SION-719 to the standard medication Trikafta is safe and works better for people with cystic fibrosis who have a specific genetic type. It will involve about 16 people who are already taking Trikafta. Researchers will ch…

This study aims to understand how a powerful cystic fibrosis drug combination works in children's bodies. Researchers will measure drug levels in the blood of 150 kids aged 2-17 who are already taking the medicine. The goal is to find the best dose to control the disease while mi…

This study is testing if small wearable sensors can detect early signs of a serious chest infection in adults with cystic fibrosis or bronchiectasis. Participants will wear the sensors while receiving a standard two-week course of antibiotics for an infection. The goal is to see …

This study is testing whether a smartphone-based self-help therapy program can reduce anxiety and depression in adults living with cystic fibrosis (CF). The program, called the ACT with CF Self-Help Toolkit, uses short video lessons to teach new ways to manage difficult feelings …

This study is testing a new wellness program designed to help adults with cystic fibrosis who struggle with severe fatigue and poor sleep. The program combines virtual coaching sessions with strategies to improve sleep and increase physical activity. Researchers will enroll 80 pa…

This study aims to check the accuracy and consistency of various laboratory tests and research procedures used to study chronic diseases like obesity, diabetes, and heart failure. It will enroll up to 100 adults, both healthy and with certain conditions, to perform tests multiple…

This UK study aims to understand why some people with cystic fibrosis respond better than others to standard antibiotic treatments during severe lung flare-ups. Researchers will follow 200 participants who are at risk of these flare-ups, collecting samples and tracking their reco…

This study is testing whether an online education program can help children with cystic fibrosis and their parents better understand health information. Researchers will enroll 104 children (ages 6-11) and their parents, randomly assigning half to receive the online classes. The …

This study is testing a new mobile app called OnTrackCF to see if it's easy to use and helpful for adults with cystic fibrosis (CF). Researchers want to know if people will use the app's features to help manage their daily CF medication routine. The goal is to gather feedback to …

This study aims to understand how two genetic conditions—Alpha-1 Antitrypsin Deficiency and Cystic Fibrosis—affect the function of special immune cells in the lungs called macrophages. Researchers will recruit 220 adults with these conditions to collect blood samples and measure …

This study aims to understand how pregnancy and early parenthood affect women with cystic fibrosis (CF) and how their children develop in early life. Researchers will observe 60 participants across three groups: women planning pregnancy or pregnant, their infants up to age 2, and…

This study aims to better understand lung function in people with cystic fibrosis using advanced imaging techniques. Researchers will use special MRI scans that involve breathing a harmless gas, along with detailed breathing tests, to create detailed pictures of how air moves thr…

This study aims to understand how common diabetes-related complications are in people with cystic fibrosis who have had diabetes for at least five years. Researchers will examine 200 adolescents and adults to check for eye, kidney, and nerve problems, as well as heart disease ris…

This study is testing whether a simple phone app can reliably measure muscle fatigue in people with cystic fibrosis (CF). Researchers will compare muscle fatigue in 34 people with CF to 34 healthy people using a chair-stand test recorded by the app. The goal is to see if this eas…

This study aims to understand if bacteria found in household water, dust, and soil contribute to serious lung infections in people with cystic fibrosis (CF). Researchers will compare homes of 120 CF patients—some with these infections and some without—to identify common environme…