CYSTIC FIBROSIS (CF)

This trial investigates whether children and teens with cystic fibrosis who are already taking highly effective modulator therapy can safely use inhaled airway clearance treatments only when they have a respiratory illness, instead of every day. Participants stop their usual dail…

This study tests whether verapamil, a common blood pressure medication, can help protect insulin-producing cells in people with cystic fibrosis who have early blood sugar problems or diabetes. Participants take verapamil for several weeks, and researchers measure changes in insul…

This study will test whether a nutrition supplement with different forms of certain nutrients works better than standard supplements for adults with cystic fibrosis. Sixty participants will take the supplement for six weeks, and researchers will measure nutrient levels in their b…

This study tests a new lab-made enzyme called NHS7108 in people with exocrine pancreatic insufficiency (EPI), a condition where the pancreas doesn't make enough enzymes to digest food. About 66 adults will take either NHS7108 or the standard enzyme Zenpep for 14 days each, while …

This study aims to develop a more accurate test for cystic fibrosis (CF) using lab-grown mini organs called organoids, made from a small piece of gut tissue. The researchers will compare this new test with current methods like sweat tests and genetic testing in 80 people who are …

This study looks at whether people with cystic fibrosis (CF) who take newer modulator drugs are developing heart disease. Researchers will use ultrasound to measure blood vessel and heart health, then repeat the tests a year later to see how things change. They will also check if…

This study will enroll 200 children with cystic fibrosis (100 Hispanic, 100 non-Hispanic white) to measure indoor and outdoor air pollution and see how it relates to lung function, inflammation, and airway bacteria. Researchers hope to understand why Hispanic children often have …

This study explores whether MRI can produce clear images of the lungs and airways in people with cystic fibrosis (CF) and healthy volunteers. Researchers will use computer assistance to measure airway size and shape, and repeat the MRI two years later to see if changes occur. A s…