CYSTIC FIBROSIS (CF)

This study tests a new enzyme called NHS7108 in people whose pancreas doesn't make enough digestive enzymes (exocrine pancreatic insufficiency). About 66 adults will take either the new enzyme or a standard enzyme for 14 days each, while eating a controlled diet. The goal is to s…

This study aims to see if one nutrition supplement works better than another for adults with cystic fibrosis. Researchers will measure nutrient levels in the blood before and after 6 weeks of taking the supplement. The study involves 60 adults who have cystic fibrosis and take a …

This early-stage trial tests whether a mixture of natural viruses called AchromoPhage is safe for adults with cystic fibrosis who have long-term lung infections from Achromobacter bacteria. Twelve participants will receive the treatment by inhalation, IV, or both, and be monitore…

This study aims to develop a more accurate test for cystic fibrosis (CF) using lab-grown 'mini organs' from a small piece of gut tissue. These organoids can show if the CF gene is working correctly, helping diagnose people with rare CF genes who are hard to diagnose with current …

This study explores whether MRI can create detailed images of the lungs and airways in children and teens with cystic fibrosis (CF) and healthy volunteers. Researchers will use computer assistance to measure airway size and shape, and repeat scans after two years to track changes…

This study looks for new methods to detect harmful bacteria in the lungs of people with cystic fibrosis (CF). Because newer CF treatments make it harder to cough up sputum, researchers will collect saliva, blood, urine, and breath samples from 300 participants to see if these can…