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New enzyme could help digest food for those with pancreatic problems

NCT ID NCT07559175

Not yet recruiting Disease control Sponsor: Aimmune Nestlé Health Science US R&D, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new lab-made enzyme called NHS7108 in people with exocrine pancreatic insufficiency (EPI), a condition where the pancreas doesn't make enough enzymes to digest food. About 66 adults will take either NHS7108 or the standard enzyme Zenpep for 14 days each, while eating a controlled diet. The goal is to see if NHS7108 is safe and helps absorb nutrients from food.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
NHS7108 (a lab-made lipase enzyme)
What this could lead to
If it works, this could offer a new treatment option for people with exocrine pancreatic insufficiency, helping them digest food better.
What could go wrong
This is an early phase 2a trial with only 66 participants, so results may not apply to everyone. The new enzyme may cause side effects or not work as well as current treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cystic fibrosis exocrine pancreatic insufficiency pancreas disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTIC FIBROSIS (CF) EXOCRINE PANCREATIC INSUFFICIENCY (EPI) PANCREATIC DISEASES PANCREATIC ENZYME ABNORMALITY

Contacts and locations

Locations

  • Advent Health Medical Group

    Orlando, Florida, 32804, United States

  • Azienda Ospedaliera Universitaria Sant'Andrea

    Roma, 00189, Italy

  • Azienda Ospedaliero Universitaria Careggi - Gastroenterologia

    Florence, 50134, Italy

  • Bonifraterskie Centrum Medyczne Sp. z o.o. Oddzial w Lodzi, Szpital Zakonu Bonifratrow Sw. Jana Bozego w Lodzi - Dzial Endoskopi

    Lodz, Łódź Voivodeship, 93-357, Poland

  • Greater Glasgow and Clyde

    Glasgow, G12 0XH, United Kingdom

  • H-T. Centrum Medyczne-Endoterapia

    Śląskie, 43-100, Poland

  • H. General de Málaga - Endocrinología

    Málaga, 29010, Spain

  • HonorHealth Research Institute

    Scottsdale, Arizona, 85258, United States

  • Hospital Clinic De Barcelona - Cirug-ía General y Digestiva

    Madrid, Barcelona, 46026, Spain

  • Hospital Universitari Arnau de Vilanova de Lleida

    Lleida, 25198, Spain

  • Hospital Universitario y Politecnico La Fe - Neumología

    Valencia, 46026, Spain

  • Humanitas Research Hospital

    Rozzano, Lombardy, 20089, Italy

  • IRCCS Ospedale San Raffaele - Endoscopia Biliopancreatica

    Milan, 20132, Italy

  • Johns Hopkins Medicine - Pulmonary and Critical Care

    Baltimore, Maryland, 21205, United States

  • Johnson County Clin-Trials (JCCT)

    Lenexa, Kansas, 66219, United States

  • Keck Hospital of USC

    Los Angeles, California, 90033, United States

  • Liverpool University Hospitals NHS Foundation Trust - Royal Liverpool University Hospital

    Liverpool, Merseyside, L7 8XP, United Kingdom

  • MC Hipokrat-N - Gastroenterology

    Plovdiv, 4000, Bulgaria

  • MH Egészségügyi Központ - Gasztroenterológiai Osztály

    Budapest, 1062, Hungary

  • Maine Medical Center - Division of Pulmonary and Critical Care Medicine

    Portland, Maine, 04102, United States

  • Medical Center Excelsior base 3

    Sofia, 1463, Bulgaria

  • Medical Center Medconsult Pleven

    Pleven, 5800, Bulgaria

  • Medical Center Medconsult Pleven, Lovech branch

    Lovech, 5500, Bulgaria

  • Semmelweis Egyetem. Sebeszeti, Transzplantacios es Gasztroenterologiai Klinika - Gasztroenterologiai Osztaly

    Budapest, 1082, Hungary

  • Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar I. sz. Belgyogyaszati Klinika

    Csongrád, 6720, Hungary

  • The Newcastle Upon Tyne Hospitals NHS Foundation Trust - Royal Victoria Infirmary

    Newcastle upon Tyne, NE1 4LP, United Kingdom

  • The Ohio State University College of Medicine (OSUCOM)

    Columbus, Ohio, 43210, United States

  • University Hospitals Cleveland Medical Center/Rainbow Babies & Children's Hospital

    Cleveland, Ohio, 44106, United States

  • University of Southern California University Hospital (USCUH) - Internal Medicine

    Los Angeles, California, 90033, United States

  • WIP Warsaw IBD Point Profesor Kierkus

    Pomorskie, Warszawa, 04-501, Poland

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