UF researchers probe why lung defenses fail in two genetic diseases

NCT ID NCT01851642

Recruiting now Knowledge-focused Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study from the University of Florida is looking at how two genetic lung conditions—Alpha-1 antitrypsin deficiency and cystic fibrosis—affect immune cells called macrophages. Researchers will collect blood and measure lung function in 220 adults to see how well these cells work. The goal is to better understand the disease process, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could reveal why lung immune cells work poorly in these diseases, pointing toward new treatment targets.
What could go wrong: This is an observational study, not a treatment trial. It will not directly improve health, and results may not lead to therapies for years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alpha 1-antitrypsin deficiency cystic fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AAT DEFICIENCY AATD ALPHA 1-ANTITRYPSIN DEFICIENCY CYSTIC FIBROSIS (CF)

Contacts and locations

Locations

Shands at the University of Florida
RECRUITING

Gainesville, Florida, 32610, United States

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