Breath, blood, and saliva tests could replace sputum for CF lung infections
NCT ID NCT07312734
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study looks for better ways to find harmful bacteria in the lungs of people with cystic fibrosis. Traditional sputum tests are becoming harder to use because newer CF treatments reduce mucus. Researchers will collect samples like saliva, blood, urine, and breath from 300 participants to see if these can reliably detect infections.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to better, easier diagnostic tests for lung infections in people with cystic fibrosis, especially those who cannot produce sputum.
- What could go wrong
- This is an observational study, not a treatment trial. It may not directly improve health outcomes, and new tests may not prove more accurate than current methods.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Froedtert & Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Nationwide Children's Hospital
NOT_YET_RECRUITINGColumbus, Ohio, 43205, United States
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The Minnesota Cystic Fibrosis Center
RECRUITINGMinneapolis, Minnesota, 55455, United States
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University of California San Diego
NOT_YET_RECRUITINGLa Jolla, California, 92037, United States
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University of Nebraska Medical Center
NOT_YET_RECRUITINGOmaha, Nebraska, 69198, United States
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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University of Texas Southwestern
RECRUITINGDallas, Texas, 75390, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Breathing vs. beating: which technique clears lungs better in cystic fibrosis?
- Could modern CF drugs make daily inhaled treatments obsolete?
- New study investigates hidden heart risks in cystic fibrosis patients on modern drugs
- Blood pressure drug may help preserve insulin in cystic fibrosis
- Hidden toll: depression and anxiety in kids with cystic fibrosis
- Air pollution may worsen cystic fibrosis in kids, study hopes to find out