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Walking downhill may boost heart health and strength in type 2 diabetes

NCT ID NCT07693296

Disease control Sponsor: Acibadem University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study compares two types of walking exercise for people with type 2 diabetes: walking on a downhill slope versus walking on flat ground. Over 8 weeks, participants will walk twice a week on a treadmill under supervision. Researchers will measure changes in walking distance, muscle strength, heart rate variability, fatigue, and blood sugar control. The goal is to see if downhill walking offers extra benefits for functional capacity and cardiovascular health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
downhill walking training
What this could lead to
If downhill walking proves more effective than level walking, it could offer a simple, low-cost exercise option to help people with type 2 diabetes improve their physical fitness and heart health.
What could go wrong
This is a small, early-stage study with only 34 participants, so results may not apply to everyone. The benefits of downhill walking may turn out to be no better than walking on flat ground.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have been diagnosed with Type 2 diabetes mellitus according to the American Diabetes Association (ADA) diagnostic criteria * Be able to walk independently and be physically capable of walking on a treadmill * Have no acute cardiovascular, neurological, or orthopedic conditions that would prevent participation in the exercise program * No major changes to antidiabetic or cardiometabolic treatments within the last 3 months * To be under regular follow-up and in a stable clinical condition * To have been informed about the study and to provide written informed consent Exclusion Criteria: * Patients with severe peripheral neuropathy or a lack of protective sensation * Lower extremity amputation * Diabetic foot ulcer or the presence of severe skin lesions that impair walking * Proliferative diabetic retinopathy or advanced retinopathy that could pose a risk of complications during exercise * Severe diabetic nephropathy (eGFR \<30 mL/min/1.73 m² or macroalbuminuria \>300 mg/g) * Uncontrolled hypertension (systolic blood pressure \>200 mmHg and/or diastolic blood pressure \>110 mmHg) * Fasting blood glucose level \>250 mg/dL with signs of ketosis * Unstable angina pectoris, a history of myocardial infarction within the past 6 months, or a history of clinically significant severe arrhythmia * Advanced heart failure (NYHA Class III-IV) * Having a chronic respiratory disease * Having participated in a regular exercise, sports, or physical therapy program within the past 6 months

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aerobic exercise Diabete type 2 Walking

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Bezmialem Vakıf University Dragos Hospital

    RECRUITING

    Istanbul, Maltepe, Turkey (Türkiye)

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