Last-Resort drug access opens for advanced pancreatic cancer patients

NCT ID NCT07573215

Disease control Sponsor: Revolution Medicines, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 02, 2026 · Updated 14 times

Summary

This program offers daraxonrasib to adults with metastatic pancreatic cancer that has worsened after prior treatment and who have no other good options. It is for patients who cannot join ongoing clinical trials. The goal is to provide access to this experimental drug when no standard therapy is available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages: 18 years and older
Sex: Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * At least 18 years old and has provided informed consent. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Histologically or cytologically confirmed PDAC with metastatic disease. * Evidence of active disease progression during or following the most recent line of systemic therapy for PDAC, based on investigator assessment. * At least one prior line of systemic therapy in the metastatic setting, which must include either a fluoropyrimidine-based or gemcitabine-based regimen. * Received and progressed, been intolerant to prior standard therapy, or no longer expected to benefit from standard therapies. * Adequate bone marrow, renal, hepatic, and coagulation functions. * Ineligible for, or unable to enroll in, another clinical trial of daraxonrasib, if available. * Able to take oral medications Exclusion Criteria: * History of known central nervous system metastatic disease. * Concurrent systemic anticancer therapy. * Significant cardiovascular disease. * Major GI conditions that may affect the ability to take or absorb daraxonrasib (patients with prior Whipple procedure are eligible). * Active uncontrolled systemic infection. * Major surgery within 28 days before enrollment. * Additional inclusion and exclusion criteria may apply.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm pancreatic adenocarcinoma pancreatic adenosquamous carcinoma pancreatic ductal adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metastatic pancreas adenocarcinoma Pancreatic adenocarcinoma Pancreatic adenocarcinoma metastatic Pancreatic adenosquamous carcinoma Pancreatic cancer Pancreatic cancer metastatic PDAC Pdac - pancreatic ductal adenocarcinoma

Contacts and locations

Locations

Advanced Cancer Treatment Centers

Brooksville, Florida, 36413, United States
Advent Health

Orlando, Florida, 32803, United States
Advent Health Shawnee Mission

Merriam, Kansas, 66204, United States
AdventHealth Porter

Denver, Colorado, 80210, United States
Advocate Health Care

Downers Grove, Illinois, 60515, United States
Alabama Cancer Care of Ft Payne

Fort Payne, Alabama, 35967, United States
Alabama Cancer Care of Tuscaloosa

Tuscaloosa, Alabama, 35406, United States
Alabama Oncology

Birmingham, Alabama, 35243, United States
Alaska Oncology and Hematology

Anchorage, Alaska, 99508, United States
Allegheny Health Network Cancer Institute

Butler, Pennsylvania, 15212, United States
Allegheny Valley Hospital

Natrona Heights, Pennsylvania, 15212, United States
Alliance Cancer Specialists

Media, Pennsylvania, 19063, United States
American Oncology Network - Oncology Consultants

Houston, Texas, 77024, United States
Ascension Medical Group St. Vincent

Newburgh, Indiana, 47630, United States
Ascension Sacred Heart

Pensacola, Florida, 32504, United States
Atrium Health

Charlotte, North Carolina, 28204, United States
Aultman Hospital

Canton, Ohio, 44170, United States
Aurora Medical Center

Grafton, Wisconsin, 53024, United States
Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States
Bakar Precision Cancer Medicine Building

San Francisco, California, 94143, United States
Baptist Cancer Center

Memphis, Tennessee, 38120, United States
Baptist Health Lexington

Lexington, Kentucky, 40503, United States
Baptist Hospital of Miami

Miami, Florida, 33176, United States
Baylor Scott & White Health

Temple, Texas, 76508, United States
Beacon Clinic

Post Falls, Idaho, 83854, United States
Bellin Health

Green Bay, Wisconsin, 54313, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Blessing Hospital

Quincy, Illinois, 62301, United States
Blood and Cancer Center

Canfield, Ohio, 44406, United States
Bon Secours St. Francis Cancer Center

Charleston, South Carolina, 29414, United States
Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, 19010, United States
California Cancer Associates for Research and Excellence

Fresno, California, 93720, United States
Cancer Center of Kansas

Wichita, Kansas, 67214, United States
Cancer Specialists of North Florida

Jacksonville, Florida, 32256, United States
Cancer and Blood Specialists of Arizona

Casa Grande, Arizona, 85122, United States
Cancer and Blood Specialty Clinics

Fountain Valley, California, 92708, United States
Care Oncology Center

Chula Vista, California, 91911, United States
Carolina BioOncology Institute

Huntersville, North Carolina, 28078, United States
Carti Cancer Center

Little Rock, Arkansas, 72205, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Central Georgia Cancer Care

Macon, Georgia, 31210, United States
City of Hope Cancer Center (California)

Duarte, California, 91010, United States
City of Hope Chicago

Zion, Illinois, 60099, United States
City of Hope Phoenix

Goodyear, Arizona, 85338, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 95000, United States
Columbia University

New York, New York, 10022, United States
Columbia University Irving Medical Center

New York, New York, 10032, United States
CommonSpirit

San Luis Obispo, California, 93401, United States
CommonSpirit Oncology Mercy

Durango, Colorado, 81301, United States
Community Medical Center

Toms River, New Jersey, 08755, United States
Compass Oncology

Happy Valley, Oregon, 97223, United States
Covenant Health - Joe Arrington Cancer Research and Treatment Center

Lubbock, Texas, 79410, United States
Covenant HealthCare

Saginaw, Michigan, 48604, United States
DHR Health

Edinburg, Texas, 78539, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Deaconess Health System

Newburgh, Indiana, 47630, United States
Desert Care Network Comprehensive Cancer

Palm Springs, California, 92262, United States
Dosik Hematology and Oncology

Brooklyn, New York, 11215, United States
Dothan Hematology and Oncology

Dothan, Alabama, 36303, United States
Duke Cancer Institute

Durham, North Carolina, 27710, United States
Eastern Connecticut Hematology and Oncology

Norwich, Connecticut, 06360, United States
El Camino Health

Mountain View, California, 94040, United States
Emory University Hospital

Atlanta, Georgia, 30322, United States
Emplify Health by Gundersen

La Crosse, Wisconsin, 05461, United States
Endeavor Health Cancer Institute

Naperville, Illinois, 60126, United States
Essentia Health

Duluth, Minnesota, 55805, United States
Florida Cancer Specialists and Research Institute

Naples, Florida, 32746, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Franciscan Alliance Health

Indianapolis, Indiana, 46237, United States
Fred Hutch Cancer Center

Seattle, Washington, 98109, United States
Frederick Health

Frederick, Maryland, 21701, United States
Genesis Cancer and Blood Institute

Hot Springs, Arkansas, 71913, United States
Guthrie Sayre

Sayre, Pennsylvania, 18840, United States
HSHS St. Mary's Hospital Medical Center

Green Bay, Wisconsin, 54303, United States
Hawai'i Pacific Health

Honolulu, Hawaii, 96814, United States
Health Partners Frauenshuh Cancer Center

Saint Louis Park, Minnesota, 55426, United States
Health Partners Oncology

Saint Paul, Minnesota, 55101, United States
HealthPartners Frauenshuh Cancer Center

Saint Louis Park, Minnesota, 55426, United States
Hematology & Oncology Associates of NEPA

Dunmore, Pennsylvania, 18512, United States
Hematology Oncology Associates of Fredericksburg

Fredericksburg, Virginia, 22408, United States
Hematology Oncology Consultants

Royal Oak, Michigan, 48073, United States
Henry Ford Health

Detroit, Michigan, 48202, United States
Hirschfeld Oncology

Brooklyn, New York, 11206, United States
Holy Cross Health - Phil Smith Neuroscience Institute ALS Multidisciplinary Clinic

Orlando, Florida, 33308, United States
Honor Health

Scottsdale, Arizona, 85258, United States
Houston Methodist Hospital- Cancer Center

Houston, Texas, 77030, United States
Huntsman Cancer Institute & Hospital

Salt Lake City, Utah, 84112, United States
Illinois Cancer Specialist

Arlington Heights, Illinois, 60005, United States
Illinois CancerCare

Peoria, Illinois, 61615, United States
Indiana University School of Medicine

Indianapolis, Indiana, 46202, United States
Inova Schar Cancer

Fairfax, Virginia, 22031, United States
Intercoastal Medical Group

Sarasota, Florida, 34232, United States
Intermountain Health

Denver, Colorado, 80211, United States
Jackson Oncology Associates

Jackson, Mississippi, 39202, United States
Jasonway Cancer Center

Columbus, Ohio, 43214, United States
Johns Hopkins

Baltimore, Maryland, 21231, United States
Kadlec Regional Medical Center

Kennewick, Washington, 99336, United States
Karmanos Cancer Institute (Barbara Ann Karmanos Cancer Hospital)

Detroit, Michigan, 48201, United States
Kettering Health Cancer Center

Kettering, Ohio, 45429, United States
LSU LCMC Health Cancer Center

New Orleans, Louisiana, 70112, United States
Lahey Clinic

Burlington, Massachusetts, 01805, United States
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Lehigh Valley Hospital

Allentown, Pennsylvania, 18103, United States
Lindenberg Cancer & Hematology Center

Marlton, New Jersey, 08053, United States
Logan Health

Kalispell, Montana, 59901, United States
Lynn Cancer Institute - Boca Raton Regional Hospital

Boca Raton, Florida, 33487, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
MD Anderson at Cooper

Camden, New Jersey, 08103, United States
Marin Cancer Care

Greenbrae, California, 94904, United States
Marshfield Medical Center

Marshfield, Wisconsin, 54449, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic - Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic - Florida

Jacksonville, Florida, 32224, United States
Mayo Clinic Minnesota

Rochester, Minnesota, 55905, United States
McFarland Clinic

Ames, Iowa, 50010, United States
McLeod Health

Florence, South Carolina, 29506, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Cancer Institute

Hollywood, Florida, 33021, United States
Memorial Sloan Kettering Cancer Center

Long Island City, New York, 11101, United States
Mercy Health - Paducah Cancer Center

Paducah, Kentucky, 42003, United States
Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Joplin

Joplin, Missouri, 64804, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Springfield

Springfield, Missouri, 65807, United States
Mercy Hospital St. Louis-South

St Louis, Missouri, 63128, United States
Mercy Medical Center

Cedar Rapids, Iowa, 52403, United States
Methodist Richardson Cancer Center

Richardson, Texas, 75082, United States
Mid America Cancer Care

Kansas City, Missouri, 64132, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Montefiore Medical Center

The Bronx, New York, 10461, United States
Montgomery Cancer Center

Montgomery, Alabama, 36106, United States
Monument Health Cancer Care Institute

Rapid City, South Dakota, 57701, United States
Mount Sinai Medical Center of Florida

Miami Beach, Florida, 33140, United States
Mountain Health Clinic

Natick, Massachusetts, 01760, United States
NHO Revive Research Institute

Lincoln, Nebraska, 68506, United States
NYU Langone Health

New York, New York, 10016, United States
Nebraska Cancer Specialists

Omaha, Nebraska, 68130, United States
New England Cancer Specialists

Topsham, Maine, 04086, United States
New York Cancer and Blood Specialists

New York, New York, 11967, United States
New York Oncology Hematology

Albany, New York, 12206, United States
North Side Hospital - Atlanta Cancer Care

Atlanta, Georgia, 30342, United States
NorthBay Health Heidi Y Campini Cancer Center

Vacaville, California, 95687, United States
Northwell Health

Lake Success, New York, 11042, United States
Northwest Georgia Oncology Centers

Marietta, Georgia, 30060, United States
Northwest Oncology & Hematology

Rolling Meadows, Illinois, 60008, United States
Northwestern University

Chicago, Illinois, 60611, United States
Norton Cancer Institute

Louisville, Kentucky, 40217, United States
Norwalk Hospital

Norwalk, Connecticut, 06856, United States
OHC (Oncology Hematology Care)

Cincinnati, Ohio, 45242, United States
OSF Cancer Institute

Peoria, Illinois, 61637, United States
OU Health Science Center - Stephenson Cancer Center

Oklahoma City, Oklahoma, 73104, United States
Ochsner Health System

New Orleans, Louisiana, 70121, United States
Ogden Clinic

Ogden, Utah, 84405, United States
Ohio Health

Columbus, Ohio, 43214, United States
OhioHealth Mansfield Hospital

Columbus, Ohio, 43214, United States
Oncology Hematology Associates

Springfield, Missouri, 65807, United States
Oregon Oncology Specialists

Salem, Oregon, 97301, United States
Overlook Medical Center - Medical Diagnostic Associates - Atlantic Medical Group

Morristown, New Jersey, 07960, United States
Owensboro Health Mitchell Memorial Cancer Center

Owensboro, Kentucky, 42303, United States
Pacific Cancer Care

Monterey, California, 93940, United States
PanOncology Centre

San Juan, 00909, Puerto Rico
Paoli Hospital

Paoli, Pennsylvania, 19301, United States
Park Nicollet Specialty Center

Saint Louis Park, Minnesota, 55426, United States
Parkview Packnett Family Cancer Institute

Fort Wayne, Indiana, 46845, United States
Piedmont Cancer Institute - Atlanta

Atlanta, Georgia, 30318, United States
Piedmont Columbus Regional Midtown

Columbus, Georgia, 31904, United States
Piedmont Physicians Medical Oncology

Atlanta, Georgia, 30318, United States
Pratt Cancer Center

St Louis, Missouri, 63141, United States
Premier Health OH

Dayton, Ohio, 45459, United States
Premier Health OH

Middletown, Ohio, 45005, United States
Providence Medical Center

Portland, Oregon, 97213, United States
Providence Medical Foundation

Santa Rosa, California, 95403, United States
Providence St. Jude

Fullerton, California, 92835, United States
Providence St. Mary Medical Center

Walla Walla, Washington, 99362, United States
Providence Swedish Cancer Institute

Seattle, Washington, 98104, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Riverside Health

Newport News, Virginia, 23320, United States
Rochester Regional Health

Rochester, New York, 14626, United States
Rocky Mountain Cancer Center

Aurora, Colorado, 80012, United States
Rutgers Cancer Institute

New Brunswick, New Jersey, 08903, United States
Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Samaritan Hemotology and Oncology

Corvallis, Oregon, 97330, United States
Sanford Health

Sioux Falls, South Dakota, 57104, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58102, United States
Sarah Cannon Cancer Institute

Nashville, Tennessee, 37203, United States
Scripps Clinic Torrey Pines

San Diego, California, 92037, United States
Seattle Integrative Cancer Center

Renton, Washington, 98057, United States
Southern Cancer Center

Daphne, Alabama, 36526, United States
Southern Cancer Center

Mobile, Alabama, 36608, United States
Spartanburg Regional Healthcare System - Gibbs Cancer Center & Research Institute

Greer, South Carolina, 29651, United States
St Luke's Cancer Institute

Boise, Idaho, 83712, United States
St. Elizabeth Healthcare

Edgewood, Kentucky, 41017, United States
St. Luke's University Health Network

Bethlehem, Pennsylvania, 18015, United States
Stanford University

Stanford, California, 94305, United States
Stony Brook University Hospital

Stony Brook, New York, 11794, United States
Summit Health

Florham Park, New Jersey, 07932, United States
Sutter Health

Sacramento, California, 95816, United States
Sutter Health

San Francisco, California, 94115, United States
Swedish Cancer Institute Treatment Center

Seattle, Washington, 98104, United States
Sylvester Comprehensive Cancer Center

Miami, Florida, 33136, United States
Tampa General Hospital

Tampa, Florida, 33606, United States
Tennessee Cancer Specialists

Knoxville, Tennessee, 37919, United States
Tennessee Oncology

Nashville, Tennessee, 37203, United States
Texas Oncology

Pearland, Texas, 77584, United States
The Cancer & Hematology Centers

Grand Rapids, Michigan, 49546, United States
The Kaiser Permanente Medical Group

Roseville, California, 95661, United States
The Mount Sinai Hospital

New York, New York, 10029, United States
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43221, United States
The Queen's Medical Center

Honolulu, Hawaii, 96813, United States
ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54611, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Trinity Health Hospital

Ypsilanti, Michigan, 48197, United States
UC Health Memorial Health System

Colorado Springs, Colorado, 80920, United States
UCHealth Poudre Valley Hospital

Fort Collins, Colorado, 80528, United States
UCI Health

Orange, California, 92612, United States
UCLA Health Westlake Village

Los Angeles, California, 90095, United States
UCSF John Muir Health

Walnut Creek, California, 94598, United States
UH Seidman Cancer Centre

Cleveland, Ohio, 44106, United States
UMass Memorial Medical Center

Worcester, Massachusetts, 01655, United States
UPMC Hillman Cancer Center

West Mifflin, Pennsylvania, 15122, United States
UPMC Western Maryland

Pittsburgh, Pennsylvania, 15224, United States
USA Health Mitchell Cancer Institute

Mobile, Alabama, 36604, United States
USC Norris Comprehensive Cancer Hospital

Los Angeles, California, 90033, United States
USOR: Minnesota Oncology Hematology, PA

Edina, Minnesota, 55435, United States
UT Health San Antonio MD Anderson Cancer Center

San Antonio, Texas, 78229, United States
UW Health Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53072, United States
University Hospital - MU Health Care

Columbia, Missouri, 65212, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Arizona Cancer Center

Tucson, Arizona, 85719, United States
University of California

Los Angeles, California, 90095, United States
University of California - San Francisco

Oakland, California, 94158, United States
University of Chicago Medical Center

Chicago, Illinois, 60637, United States
University of Iowa

Waukee, Iowa, 50263, United States
University of Iowa Cancer Services Quad Cities

Bettendorf, Iowa, 52722, United States
University of Kansas Medical Center

Westwood, Kansas, 66205, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68114, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center (UPMC)

Pittsburgh, Pennsylvania, 15224, United States
University of Texas Southwestern Medical

Dallas, Texas, 75390, United States
University of Vermont Medical Center

Burlington, Vermont, 05401, United States
University of Wisconsin

Madison, Wisconsin, 53792, United States
Utah Cancer Specialists (UCS)

Salt Lake City, Utah, 84106, United States
VCU Health

Richmond, Virginia, 23219, United States
Virginia Cancer Institute

Richmond, Virginia, 23229, United States
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States
Virginia Mason Medical Center

Seattle, Washington, 98101, United States
Virginia Oncology Associates

Hampton, Virginia, 23606, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine

St Louis, Missouri, 63141, United States
West Cancer Center

Germantown, Tennessee, 38138, United States
Willamette Valley Cancer Institute

Springfield, Oregon, 97477, United States
William Beaumont Army Medical Center - Fort Bliss

Fort Bliss, Texas, 79918, United States
Willis Knighton Cancer Center

Shreveport, Louisiana, 71103, United States
Yale New Haven Hospital

New Haven, Connecticut, 06519, United States
Zangmeister Cancer Center

Columbus, Ohio, 43219, United States

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