New daily pill could help millions shed pounds

NCT ID NCT07667803

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This phase 3 trial is testing a new daily pill called elecoglipron for weight loss in 4500 adults who are obese or overweight, with or without type 2 diabetes. Participants will take the pill or a placebo for 72 weeks, alongside diet and exercise. The main goal is to see how much weight they lose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Elecoglipron (a daily pill)
What this could lead to: If it works, this could offer a new daily pill for significant weight loss in people with obesity or overweight, including those with type 2 diabetes.
What could go wrong: This is a large phase 3 trial, but it's still experimental. The drug may not work as hoped, could have side effects, or may not be better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

WEIGHT MANAGEMENT

Contacts and locations

Locations

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Birmingham, Alabama, 35205, United States
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Dothan, Alabama, 36305, United States
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Chandler, Arizona, 85225, United States
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Peoria, Arizona, 85382, United States
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Little Rock, Arkansas, 72205, United States
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Lynwood, California, 90262, United States
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Rolling Hills Estates, California, 90274, United States
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Sacramento, California, 95821, United States
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Arvada, Colorado, 80002, United States
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New Haven, Connecticut, 06511, United States
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Clearwater, Florida, 33765, United States
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Plantation, Florida, 33324, United States
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Woodstock, Georgia, 30189, United States
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Ammon, Idaho, 83406, United States
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Melrose Park, Illinois, 60160, United States
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Indianapolis, Indiana, 46254, United States
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Wichita, Kansas, 67218, United States
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Louisville, Kentucky, 40213, United States
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Alexandria, Louisiana, 71303, United States
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Baltimore, Maryland, 21229, United States
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Potomac, Maryland, 20854, United States
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White Marsh, Maryland, 21162, United States
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Ypsilanti, Michigan, 48197, United States
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Ridgeland, Mississippi, 39157, United States
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Kansas City, Missouri, 64114, United States
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St Louis, Missouri, 63123, United States
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Reno, Nevada, 89511, United States
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Albuquerque, New Mexico, 87106, United States
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Albany, New York, 12205, United States
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Laurelton, New York, 11413, United States
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Long Island City, New York, 11106, United States
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Greensboro, North Carolina, 27408, United States
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Raleigh, North Carolina, 27609, United States
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Rocky Mount, North Carolina, 27804, United States
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Statesville, North Carolina, 28625, United States
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Columbus, Ohio, 43228, United States
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Dayton, Ohio, 45424, United States
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Edmond, Oklahoma, 73013, United States
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Tulsa, Oklahoma, 74133, United States
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Portland, Oregon, 97223, United States
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DuBois, Pennsylvania, 15801, United States
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Newport, Pennsylvania, 17074, United States
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Philadelphia, Pennsylvania, 19104, United States
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East Providence, Rhode Island, 02914, United States
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Charleston, South Carolina, 29407, United States
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Gaffney, South Carolina, 29340, United States
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Rapid City, South Dakota, 57701, United States
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Franklin, Tennessee, 37067, United States
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Knoxville, Tennessee, 37912, United States
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Dallas, Texas, 75254, United States
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Houston, Texas, 77081, United States
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Humble, Texas, 77346, United States
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Irving, Texas, 75063, United States
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Sandy City, Utah, 84070, United States
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Midlothian, Virginia, 23112, United States
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Morgantown, West Virginia, 26501, United States
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Buenos Aires, 1061, Argentina
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Buenos Aires, C1425AGC, Argentina
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CABA, 1056, Argentina
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CABA, C1120AAC, Argentina
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Caba, C1128AAF, Argentina
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Capital Federal, C1014A, Argentina
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Granadero Baigorria, S2152BOF, Argentina
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Lanus, B1824KAJ, Argentina
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Rosario, 2000, Argentina
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Rosario, S2000CVD, Argentina
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San Nicolás, B2900DMH, Argentina
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San Vicente, 5006, Argentina
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Botany, 2019, Australia
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Camberwell, 3124, Australia
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Kotara, 2289, Australia
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Maroubra, 2035, Australia
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St Albans, 3021, Australia
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St Leonards, 2065, Australia
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Belém, 66073-005, Brazil
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Brasília, 72145-450, Brazil
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Campinas, 13060-080, Brazil
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Campinas, 13092133, Brazil
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Curitiba, 80045-170, Brazil
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Fortaleza, 60430-350, Brazil
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Porto Alegre, 90430-001, Brazil
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São José dos Campos, 12230-001, Brazil
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São Paulo, 01228-000, Brazil
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São Paulo, 01236-030, Brazil
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São Paulo, 04012-180, Brazil
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Calgary, Alberta, T2V 4J2, Canada
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Calgary, Alberta, T3R 1W9, Canada
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Vancouver, British Columbia, V5Y 3W2, Canada
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Victoria, British Columbia, V8V 4A1, Canada
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Moncton, New Brunswick, E1G 1A7, Canada
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Truro, Nova Scotia, B2N 1L2, Canada
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Brampton, Ontario, L6T 0G1, Canada
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Hamilton, Ontario, L8L 5G8, Canada
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Niagara Falls, Ontario, L2H 1H5, Canada
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North York, Ontario, M6B 3H7, Canada
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Sarnia, Ontario, N7T 4X3, Canada
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Scarborough Village, Ontario, M1R 0B1, Canada
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Stouffville, Ontario, L4A1H2, Canada
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Toronto, Ontario, M3J 0K2, Canada
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Toronto, Ontario, M6G 1M2, Canada
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Toronto, Ontario, M9V 4B4, Canada
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Joliette, Quebec, J6E 6A9, Canada
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Montreal, Quebec, H4N 2W2, Canada
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Saint-Lambert, Quebec, J4P 2H4, Canada
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Terrebonne, Quebec, J6X 4P7, Canada
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Araucania, 4781151, Chile
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Concepción, 4070196, Chile
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Las Condes, 7560908, Chile
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Osorno, 5311092, Chile
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Providencia, 7500504, Chile
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Santiago, 7510187, Chile
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Santiago, 7691236, Chile
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Santiago, 8330034, Chile
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Santiago, 8331143, Chile
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Temuco, 4810345, Chile
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Binzhou, 256603, China
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Chengdu, 610078, China
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Chengdu, 610081, China
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Deyang, 618000, China
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Ganzhou, 341099, China
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Guangzhou, 510220, China
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Guangzhou, 510280, China
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Haikou, 570208, China
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Hangzhou, 310006, China
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Hangzhou, 311200, China
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Huaian, 223300, China
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Huzhou, 313003, China
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Jinan, 250001, China
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Jinzhou, 121002, China
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Kunming, CN-650034, China
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Lanzhou, 730000, China
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Linhai, 317000, China
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Liuzhou, 545006, China
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Luoyang, 471001, China
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Nanchang, 330006, China
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Nanjing, 210006, China
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Nanjing, 211100, China
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Nantong, 226001, China
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Ningbo, 315000, China
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Panjin, 124000, China
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Pingxiang, 337055, China
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Qingdao, 266035, China
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Shanghai, 200025, China
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Shanghai, 201200, China
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Shenyang, 110016, China
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Shenzhen, 518036, China
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Siping, 136000, China
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Suining, 629000, China
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Suzhou, 215006, China
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Ürümqi, 831118, China
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Wanzhou, 404000, China
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Wenzhou, 325000, China
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Wuhan, 430030, China
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Wuxi, 214023, China
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Xiangfan, 441021, China
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Xuancheng, 242000, China
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Yibin, 644000, China
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Yichang, 443003, China
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Zhengzhou, 450002, China
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Zhenjiang, 212002, China
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Zunyi, 563100, China
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Bad Oeynhausen, 32545, Germany
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Bochum, 44789, Germany
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Cologne, 50937, Germany
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Cologne, 51069, Germany
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Dresden, 01307, Germany
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Falkensee, 14612, Germany
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Gera, 07548, Germany
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Hamburg, 22607, Germany
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Leipzig, 04103, Germany
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Leipzig, 04107, Germany
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Lübeck, 23562, Germany
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Mainz, 55131, Germany
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Mannheim, 68167, Germany
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München, 80809, Germany
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Münster, 48145, Germany
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Nuremberg, 90443, Germany
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Obertshausen, 63179, Germany
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Oldenburg, 23758, Germany
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Stuttgart, 70199, Germany
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Ulm, 89073, Germany
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Wangen, 88239, Germany
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Würzburg, 97080, Germany
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Bangalore, 560 092, India
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Belagavi, 590006, India
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Bikaner, 334001, India
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Delhi, 110029, India
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Guntur, 522001, India
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Hyderabad, 500034, India
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Jodhpur, 342005, India
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Kolkata, 700014, India
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Kolkata, 700020, India
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Madurai, 625020, India
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Mumbai, 400008, India
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Mumbai, 400012, India
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Mysore, 570001, India
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Nagpur, 440010, India
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New Delhi, 110002, India
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SUSPENDED

Siliguri, 734012, India
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Bologna, 40138, Italy
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Catania, 95123, Italy
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Chieti, 66100, Italy
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Florence, 50134, Italy
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Latina, 04100, Italy
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Milan, 20154, Italy
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Pisa, 56100, Italy
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Ravenna, 48121, Italy
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Roma, 00128, Italy
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Roma, 161, Italy
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San Donato, 20097, Italy
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Amagasaki-shi, 660-0861, Japan
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Chūōku, 103-0002, Japan
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Chūōku, 1040031, Japan
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Kasugai-shi, 486-8510, Japan
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Koga-shi, 306-0232, Japan
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Maebashi, 371-8511, Japan
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Minatoku, 105-0004, Japan
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Minatoku, 108-0073, Japan
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Naka, 311-0113, Japan
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Shinjuku-ku, 169-0072, Japan
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Shizuoka, 424-0855, Japan
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Suita-shi, 564-8565, Japan
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Suita-shi, 565-0853, Japan
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Toshima-ku, 171-0014, Japan
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Yamato-shi, 242-0004, Japan
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Yokohama, 230-8765, Japan
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Yokohama, 232-0064, Japan
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Bialystok, 15-375, Poland
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Bialystok, 15-435, Poland
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Bydgoszcz, 85-796, Poland
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Kielce, 25-355, Poland
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Krakow, 30-727, Poland
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Krakow, 31-261, Poland
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NOT_YET_RECRUITING

Krakow, 31-271, Poland
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Lodz, 90-338, Poland
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NOT_YET_RECRUITING

Lublin, 20-064, Poland
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NOT_YET_RECRUITING

Lublin, 20-718, Poland
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NOT_YET_RECRUITING

Poznan, 60-354, Poland
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Poznan, 60-589, Poland
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NOT_YET_RECRUITING

Radom, 26-600, Poland
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NOT_YET_RECRUITING

Warsaw, 00-124, Poland
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NOT_YET_RECRUITING

Warsaw, 02-507, Poland
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NOT_YET_RECRUITING

Warsaw, 02-758, Poland
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NOT_YET_RECRUITING

Al-Ahsa, 36428, Saudi Arabia
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NOT_YET_RECRUITING

Dammam, 31444, Saudi Arabia
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NOT_YET_RECRUITING

Jeddah, 22384, Saudi Arabia
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NOT_YET_RECRUITING

Khobar, 31952, Saudi Arabia
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NOT_YET_RECRUITING

Riyadh, 11462, Saudi Arabia
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NOT_YET_RECRUITING

Riyadh, 12713, Saudi Arabia
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NOT_YET_RECRUITING

Bellville, 7530, South Africa
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NOT_YET_RECRUITING

Bloemfontein, 9301, South Africa
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NOT_YET_RECRUITING

Cape Town, 7500, South Africa
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NOT_YET_RECRUITING

Cape Town, 7764, South Africa
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NOT_YET_RECRUITING

Chatsworth, 4092, South Africa
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NOT_YET_RECRUITING

Claremont, 7708, South Africa
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NOT_YET_RECRUITING

Durban, 4091, South Africa
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eMkhomazi, 4170, South Africa
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NOT_YET_RECRUITING

Johannesburg, 1827, South Africa
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NOT_YET_RECRUITING

Johannesburg, 2113, South Africa
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Midrand, 1685, South Africa
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NOT_YET_RECRUITING

Wentworth, 4032, South Africa
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NOT_YET_RECRUITING

Busan, 49201, South Korea
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NOT_YET_RECRUITING

Busan, 49241, South Korea
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NOT_YET_RECRUITING

Daegu, 42415, South Korea
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NOT_YET_RECRUITING

Goyang-si, 13620, South Korea
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NOT_YET_RECRUITING

Gyeonggi-do, 13620, South Korea
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NOT_YET_RECRUITING

Incheon, 21565, South Korea
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NOT_YET_RECRUITING

Jongno-gu, 110-746, South Korea
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NOT_YET_RECRUITING

Seoul, 02447, South Korea
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NOT_YET_RECRUITING

Seoul, 120-752, South Korea
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NOT_YET_RECRUITING

Suwon, 443-721, South Korea
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NOT_YET_RECRUITING

A Coruña, 15006, Spain
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NOT_YET_RECRUITING

Almería, 04009, Spain
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NOT_YET_RECRUITING

Badalona, 08916, Spain
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NOT_YET_RECRUITING

Barcelona, 08036, Spain
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NOT_YET_RECRUITING

Barcelona, 08041, Spain
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NOT_YET_RECRUITING

Barcelona, 8035, Spain
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NOT_YET_RECRUITING

León, 24008, Spain
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NOT_YET_RECRUITING

Madrid, 28006, Spain
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NOT_YET_RECRUITING

Santander, 39008, Spain
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NOT_YET_RECRUITING

Santiago de Compostela, 15706, Spain
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NOT_YET_RECRUITING

Seville, 41003, Spain
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NOT_YET_RECRUITING

Seville, 41013, Spain
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NOT_YET_RECRUITING

Seville, 41950, Spain
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NOT_YET_RECRUITING

Tarragona, 43007, Spain
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NOT_YET_RECRUITING

Valencia, 46014, Spain
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NOT_YET_RECRUITING

Changhua, 500, Taiwan
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NOT_YET_RECRUITING

Kaohsiung City, 807, Taiwan
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NOT_YET_RECRUITING

Taichung, 402, Taiwan
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NOT_YET_RECRUITING

Taichung, 40447, Taiwan
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NOT_YET_RECRUITING

Taichung, 40705, Taiwan
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RECRUITING

Taichung, 433004, Taiwan
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NOT_YET_RECRUITING

Tainan, 704, Taiwan
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NOT_YET_RECRUITING

Tainan County, 71044, Taiwan
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NOT_YET_RECRUITING

Taipei, 10002, Taiwan
Research Site
NOT_YET_RECRUITING

Taipei, 110, Taiwan
Research Site
NOT_YET_RECRUITING

Adana, 01060, Turkey (Türkiye)
Research Site
NOT_YET_RECRUITING

Adana, 01120, Turkey (Türkiye)
Research Site
NOT_YET_RECRUITING

Adapazarı, 54290, Turkey (Türkiye)
Research Site
NOT_YET_RECRUITING

Ankara, 06530, Turkey (Türkiye)
Research Site
NOT_YET_RECRUITING

Ankara, 5000, Turkey (Türkiye)
Research Site
NOT_YET_RECRUITING

Ankara, 6230, Turkey (Türkiye)
Research Site
NOT_YET_RECRUITING

Antalya, 07059, Turkey (Türkiye)
Research Site
NOT_YET_RECRUITING

Istanbul, 34098, Turkey (Türkiye)
Research Site
NOT_YET_RECRUITING

Istanbul, 34384, Turkey (Türkiye)
Research Site
NOT_YET_RECRUITING

Istanbul, 34722, Turkey (Türkiye)
Research Site
NOT_YET_RECRUITING

Ashton-under-Lyne, OL6 6EW, United Kingdom
Research Site
NOT_YET_RECRUITING

Blackpool, FY3 7EN, United Kingdom
Research Site
NOT_YET_RECRUITING

Chesterfield, S40 4AA, United Kingdom
Research Site
NOT_YET_RECRUITING

Corby, NN17 2UR, United Kingdom
Research Site
NOT_YET_RECRUITING

Ely, CB7 5JD, United Kingdom
Research Site
NOT_YET_RECRUITING

Glasgow, G51 4TF, United Kingdom
Research Site
NOT_YET_RECRUITING

Hounslow, TW3 3LN, United Kingdom
Research Site
RECRUITING

Leicester, Le5 4PW, United Kingdom
Research Site
NOT_YET_RECRUITING

Metropolitan Borough of Wirral, CH48 5AA, United Kingdom
Research Site
NOT_YET_RECRUITING

Poole, BH16 5PW, United Kingdom
Research Site
NOT_YET_RECRUITING

Rotherham, S65 1DA, United Kingdom
Research Site
WITHDRAWN

Stowmarket, IP142SY, United Kingdom
Research Site
WITHDRAWN

Wansford, PE8 6PL, United Kingdom
Research Site
NOT_YET_RECRUITING

Witney, OX28 6JS, United Kingdom
Research Site
NOT_YET_RECRUITING

Yate, BS37 4AX, United Kingdom

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