New drug hope for rare cancer patients

NCT ID NCT06943755

Recruiting now Disease control Sponsor: Exelixis Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 10, 2026 · Updated 32 times

Summary

This study tests a new drug called zanzalintinib against the current standard drug everolimus in people with advanced neuroendocrine tumors that have already been treated. About 440 adults with tumors that cannot be removed by surgery or have spread will be randomly assigned to one of the two drugs. The goal is to see which drug better delays tumor growth and improves survival.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Exelixis Clinical Site # 4
WITHDRAWN

San Juan, 00927, Puerto Rico
Exelixis Clinical Site #1
RECRUITING

Grand Rapids, Michigan, 49546, United States
Exelixis Clinical Site #10
RECRUITING

Dallas, Texas, 75264, United States
Exelixis Clinical Site #11
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Tampa, Florida, 33612, United States
Exelixis Clinical Site #12
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Santa Monica, California, 90404, United States
Exelixis Clinical Site #13
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Fairfax, Virginia, 22031, United States
Exelixis Clinical Site #14
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Albuquerque, New Mexico, 87131, United States
Exelixis Clinical Site #15
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Salt Lake City, Utah, 84112, United States
Exelixis Clinical Site #16
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Los Angeles, California, 90033, United States
Exelixis Clinical Site #17
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Chapel Hill, North Carolina, 27599, United States
Exelixis Clinical Site #18
RECRUITING

Beverly Hills, California, 90211, United States
Exelixis Clinical Site #19
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Exelixis Clinical Site #2
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San Juan, 00909, Puerto Rico
Exelixis Clinical Site #20
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Exelixis Clinical Site #21
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Exelixis Clinical Site #22
RECRUITING

London, England, SE5 9RS, United Kingdom
Exelixis Clinical Site #23
RECRUITING

Metairie, Louisiana, 70006, United States
Exelixis Clinical Site #24
RECRUITING

Knoxville, Tennessee, 37920, United States
Exelixis Clinical Site #25
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Omaha, Nebraska, 68198, United States
Exelixis Clinical Site #26
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Seoul, 06351, South Korea
Exelixis Clinical Site #27
RECRUITING

Portland, Oregon, 97210, United States
Exelixis Clinical Site #28
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Columbus, Ohio, 43221, United States
Exelixis Clinical Site #29
RECRUITING

Vallejo, California, 94589, United States
Exelixis Clinical Site #3
RECRUITING

Charlottesville, Virginia, 22903, United States
Exelixis Clinical Site #30
RECRUITING

Seoul, 02841, South Korea
Exelixis Clinical Site #31
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Milwaukee, Wisconsin, 53226, United States
Exelixis Clinical Site #32
RECRUITING

Seoul, 03722, South Korea
Exelixis Clinical Site #33
RECRUITING

Sheffield, S10 2SJ, United Kingdom
Exelixis Clinical Site #34
RECRUITING

Seattle, Washington, 98109, United States
Exelixis Clinical Site #35
RECRUITING

Jacksonville, Florida, 32224, United States
Exelixis Clinical Site #36
RECRUITING

Phoenix, Arizona, 85054, United States
Exelixis Clinical Site #37
RECRUITING

Warsaw, 53-673, Poland
Exelixis Clinical Site #38
RECRUITING

Rochester, Minnesota, 55905, United States
Exelixis Clinical Site #39
RECRUITING

Cleveland, Ohio, 44106, United States
Exelixis Clinical Site #40
RECRUITING

Saint Leonards, New South Wales, 2065, Australia
Exelixis Clinical Site #41
RECRUITING

Seoul, 05505, South Korea
Exelixis Clinical Site #42
RECRUITING

Tucson, Arizona, 85724, United States
Exelixis Clinical Site #43
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Birmingham, Alabama, 35294, United States
Exelixis Clinical Site #44
RECRUITING

Madrid, 28046, Spain
Exelixis Clinical Site #45
RECRUITING

Katowice, 40-514, Poland
Exelixis Clinical Site #46
RECRUITING

Seoul, 03080, South Korea
Exelixis Clinical Site #47
RECRUITING

Detroit, Michigan, 48202, United States
Exelixis Clinical Site #48
RECRUITING

Graz, 8036, Austria
Exelixis Clinical Site #49
RECRUITING

Toronto, M4N3M5, Canada
Exelixis Clinical Site #5
RECRUITING

St Louis, Missouri, 63110, United States
Exelixis Clinical Site #50
RECRUITING

Liverpool, L7 8YA, United Kingdom
Exelixis Clinical Site #51
RECRUITING

Clayton, Victoria, 3168, Australia
Exelixis Clinical Site #52
RECRUITING

Tübingen, 72076, Germany
Exelixis Clinical Site #53
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Rochester, New York, 14642, United States
Exelixis Clinical Site #54
RECRUITING

Palo Alto, California, 94305, United States
Exelixis Clinical Site #55
RECRUITING

Herston, 4029, Australia
Exelixis Clinical Site #56
RECRUITING

Madrid, 28034, Spain
Exelixis Clinical Site #57
RECRUITING

Fargo, North Dakota, 58102, United States
Exelixis Clinical Site #59
RECRUITING

Buffalo, New York, 14263, United States
Exelixis Clinical Site #6
RECRUITING

Durham, North Carolina, 27710, United States
Exelixis Clinical Site #60
RECRUITING

Santander, 39008, Spain
Exelixis Clinical Site #61
RECRUITING

Ottawa, K1H8L6, Canada
Exelixis Clinical Site #62
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Seville, 41013, Spain
Exelixis Clinical Site #63
RECRUITING

Hong Kong, China
Exelixis Clinical Site #64
RECRUITING

Valencia, 46026, Spain
Exelixis Clinical Site #65
RECRUITING

Nashville, Tennessee, 37232, United States
Exelixis Clinical Site #66
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Murcia, 30008, Spain
Exelixis Clinical Site #67
RECRUITING

Woodville South, South Australia, 5011, Australia
Exelixis Clinical Site #68
RECRUITING

Clayton, Victoria, 3168, Australia
Exelixis Clinical Site #69
RECRUITING

Warsaw, Masovian Voivodeship, 02-034, Poland
Exelixis Clinical Site #7
RECRUITING

New York, New York, 10029, United States
Exelixis Clinical Site #70
RECRUITING

Roma, 00185, Italy
Exelixis Clinical Site #71
RECRUITING

Oxford, England, OX3 7LE, United Kingdom
Exelixis Clinical Site #72
RECRUITING

Gliwice, Ślaskie, 44-102, Poland
Exelixis Clinical Site #73
RECRUITING

Madrid, 28041, Spain
Exelixis Clinical Site #74
RECRUITING

Santiago de Compostela, A Coruña, 15706, Spain
Exelixis Clinical Site #75
RECRUITING

Würzburg, 97080, Germany
Exelixis Clinical Site #76
RECRUITING

Barcelona, 08029, Spain
Exelixis Clinical Site #77
RECRUITING

China, Hong Kong
Exelixis Clinical Site #78
RECRUITING

Naples, Naples, 80131, Italy
Exelixis Clinical Site #79
RECRUITING

Zaragoza, 50009, Spain
Exelixis Clinical Site #8
RECRUITING

Boston, Massachusetts, 02215, United States
Exelixis Clinical Site #80
RECRUITING

Oviedo, Principality of Asturias, 33011, Spain
Exelixis Clinical Site #9
RECRUITING

Lexington, Kentucky, 40536, United States
Exelixis Clinical Site 58
RECRUITING

Berlin, 13125, Germany

Conditions

Explore the condition pages connected to this study.

EXTRA-PANCREATIC NEUROENDOCRINE TUMOR (EPNET) EXTRA-PANCREATIC NEUROENDOCRINE TUMOR (EPNET) PANCREATIC NEUROENDOCRINE TUMOR (PNET)