New hope for neuroendocrine tumors: zanzalintinib takes on everolimus

NCT ID NCT06943755

Recruiting now Disease control Sponsor: Exelixis Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 5 times

Summary

This study compares a new drug, zanzalintinib, to the current standard drug everolimus in people with advanced neuroendocrine tumors that have already been treated. The goal is to see which drug better slows tumor growth. About 440 participants will be randomly assigned to one of the two treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zanzalintinib
What this could lead to: If it works, this could offer a new treatment option for people with advanced neuroendocrine tumors that have stopped responding to other therapies.
What could go wrong: This is an early-to-mid-stage trial, so results are not guaranteed. The new drug may not be more effective than the existing drug everolimus, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenoma, Islet Cell Neoplasm Metastasis neuroendocrine neoplasm pancreatic neuroendocrine tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTRA-PANCREATIC NEUROENDOCRINE TUMOR (EPNET) PANCREATIC NEUROENDOCRINE TUMOR (PNET)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

AdventHealth Orlando
RECRUITING

Orlando, Florida, 32804, United States
Amsterdam UMC
RECRUITING

Amsterdam, 1081 HV, Netherlands
Asan Medical Center
RECRUITING

Seoul, 5505, South Korea
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
RECRUITING

Palermo, 90127, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
RECRUITING

Bologna, 40138, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I
RECRUITING

Roma, 00161, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
RECRUITING

Orbassano to, 10043, Italy
Azienda Ospedaliero-Universitaria Sant'Andrea
RECRUITING

Roma, 00189, Italy
CHRU Strasbourg Hôpital Hautepierre
RECRUITING

Strasbourg, 67200, France
CHU Beaujon
RECRUITING

Clichy, 92110, France
CHU de Montpellier Hôpital Saint Eloi
RECRUITING

Montpellier, 34295, France
Cedars-Sinai Medical Center
RECRUITING

Beverly Hills, California, 90211, United States
Centre Eugéne Marquis
RECRUITING

Rennes, 35042, France
Centre Hospitalier Universitaire (CHU) Toulouse
RECRUITING

Toulouse, 31059, France
Centre Hospitalier Universitaire (CHU) de Lille - Hôpital Claude Huriez
RECRUITING

Lille, 59037, France
Centre Hospitalier Universitaire Nantes
RECRUITING

Nantes, 44093, France
Centre Hospitalier Universitaire de Caen Normandie
RECRUITING

Caen, 14033, France
Cliniques Universitaires Saint-Luc (UCLouvain)
RECRUITING

Woluwe-Saint-Lambert, 1200, Belgium
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
East Jefferson General Hospital
RECRUITING

Metairie, Louisiana, 70006, United States
Evangelische Lungenklinik
RECRUITING

Berlin, 13125, Germany
FDI Clinical Resesarch
WITHDRAWN

San Juan, 00927, Puerto Rico
Fiona Stanley Hospital
RECRUITING

Murdoch, 6150, Australia
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Froedtert Hospital and the Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
FutureMeds Wrocław
RECRUITING

Wroclaw, 53-673, Poland
GenesisCare North Shore
RECRUITING

St Leonards, 2065, Australia
Georgetown University
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Gustave Roussy
RECRUITING

Villejuif, 94800, France
Guy's and St Thomas' NHS Foundation Trust
RECRUITING

London, SE1 9RT, United Kingdom
Henry Ford Cancer- Detroit
RECRUITING

Detroit, Michigan, 48202, United States
Henry-Joyce Cancer Clinic
RECRUITING

Nashville, Tennessee, 37232, United States
Het Netherlands Kanker Institut (NKI)/ Antoni van Leeuwenhoek
RECRUITING

Amsterdam, 1066 CX, Netherlands
Hospices Civils de Lyon
RECRUITING

Lyon, 69003, France
Hospital Clínico Universitario de Santiago de Compostela
RECRUITING

Santiago de Compostela, 15706, Spain
Hospital General Universitario Gregorio Marañón
RECRUITING

Madrid, 28007, Spain
Hospital General Universitario J.M Morales Meseguer
RECRUITING

Murcia, 30008, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, 33011, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, 39008, Spain
Hospital Universitario Miguel Servet
RECRUITING

Zaragoza, 50009, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, 28034, Spain
Hospital Universitario Vall D'Hebron
RECRUITING

Barcelona, 8029, Spain
Hospital Universitario Vigen Del Rocío
RECRUITING

Seville, 41013, Spain
Hospital Universitario y Politécnico La Fe
RECRUITING

Valencia, 46026, Spain
Humanitas Mirasole S.p.A.
RECRUITING

Milan, 20089, Italy
Humanity and Health Clinical Trial Centre
RECRUITING

Hong Kong, China
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Hôpital Timone
RECRUITING

Marseille, 13005, France
Icahan School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Institut Jules Bordet
RECRUITING

Brussels, 1070, Belgium
Instituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Istituto Nazionale Tumori IRCCS - Fondazione Pascale
RECRUITING

Naples, 80131, Italy
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST s.r.l.
RECRUITING

Meldola, 47014, Italy
Kaiser Permanente Medical Center
RECRUITING

Vallejo, California, 94589, United States
King's College Hospital NHS Foundation Trust
RECRUITING

London, SE5 9RS, United Kingdom
Korea University Anam Hospital
RECRUITING

Seoul, 2841, South Korea
Maastricht Universitair Medisch Centrum
RECRUITING

Maastricht, 6229 HX, Netherlands
Maxima Medisch Centrum
RECRUITING

Veldhoven, 5504 DB, Netherlands
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic - Florida
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Hospital
RECRUITING

Phoenix, Arizona, 85054, United States
Medical University of Graz
RECRUITING

Graz, 8036, Austria
Medical University of Vienna
RECRUITING

Vienna, 1090, Austria
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Monash Health
RECRUITING

Clayton, 3168, Australia
NHS Greater Glasgow and Clyde
RECRUITING

Glasgow, G12 0YN, United Kingdom
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy
RECRUITING

Warsaw, 02-034, Poland
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Oddział w Gliwicach
RECRUITING

Gliwice, 44-102, Poland
Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97210, United States
Oxford University Hospitals NHS Foundation Trust
RECRUITING

Oxford, OX3 7LE, United Kingdom
Pan American Center for Oncology Trials, LLC
RECRUITING

San Juan, 00909, Puerto Rico
Paracelsus Medical University Hospital Salzburg
RECRUITING

Salzburg, 5020, Austria
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, 3000, Australia
Prince of Wales Hospital
RECRUITING

Hong Kong, China
Queen Mary Hospital
RECRUITING

Hong Kong, China
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Royal Brisbane and Women's Hospital
RECRUITING

Herston, 4029, Australia
Samodzielny Publiczny Zakład Opieki Zdrowotnej Szpital Uniwesytecki w Krakowie
RECRUITING

Krakow, 30-688, Poland
Samsung Medical Center
RECRUITING

Seoul, 6351, South Korea
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58102, United States
Seoul National University Hospital
RECRUITING

Seoul, 3080, South Korea
Severence Hospital, Yonsei University Health System
RECRUITING

Seoul, 3722, South Korea
Sheffield Teaching Hospitals NHS Foundation Trust
RECRUITING

Sheffield, S10 2SJ, United Kingdom
Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63110, United States
Stanford Cancer Center
RECRUITING

Palo Alto, California, 94305, United States
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, M4N 3M5, Canada
Swansea Bay University Health Board
RECRUITING

Swansea, SA2 8QA, United Kingdom
Texas Oncology- Baylor Charles A. Sammons Cancer Center
RECRUITING

Dallas, Texas, 75264, United States
The Cancer and Hematology Centers
RECRUITING

Grand Rapids, Michigan, 49546, United States
The Clatterbridge Cancer Centre
RECRUITING

Liverpool, L7 8YA, United Kingdom
The Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43221, United States
The Ottawa Hospital Cancer Center
RECRUITING

Ottawa, K1H 8L6, Canada
The Queen Elizabeth Hospital
RECRUITING

Woodville South, 5011, Australia
The University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
The University of Arizona Cancer Center
RECRUITING

Tucson, Arizona, 85724, United States
UCLA Health - Santa Monica Cancer Care
RECRUITING

Santa Monica, California, 90404, United States
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
University Hospital Würzburg
RECRUITING

Würzburg, 97080, Germany
University Hospitals Birmingham NHS Foundation Trust
RECRUITING

Birmingham, B15 2GW, United Kingdom
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of Kentucky Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of New Mexico Comprehensive Cancer Center
RECRUITING

Albuquerque, New Mexico, 87131, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Tennessee Medical Center
RECRUITING

Knoxville, Tennessee, 37920, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
Universitätsklinik Erlangen
RECRUITING

Erlangen, 91054, Germany
Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg
RECRUITING

Marburg, 35043, Germany
Universitätsklinikum Tübingen
RECRUITING

Tübingen, 72076, Germany
Velindre Cancer Center
RECRUITING

Cardiff, CF14 2TL, United Kingdom
Verspeeten Family Cancer Center - London Health Sciences Centre
RECRUITING

London, N6A 5W9, Canada
Virginia Cancer Specialists - Fairfax Office
RECRUITING

Fairfax, Virginia, 22031, United States
Śląskiego Uniwersytet Medyczny w Katowicach
RECRUITING

Katowice, 40-514, Poland