New hope for neuroendocrine tumors: zanzalintinib takes on everolimus

NCT ID NCT06943755

Recruiting now Disease control Sponsor: Exelixis Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a new drug, zanzalintinib, to the current standard drug everolimus in people with advanced neuroendocrine tumors that have already been treated. The goal is to see which drug better slows tumor growth. About 440 participants will be randomly assigned to one of the two treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

zanzalintinib

What this could lead to

If it works, this could offer a new treatment option for people with advanced neuroendocrine tumors that have stopped responding to other therapies.

What could go wrong

This is an early-to-mid-stage trial, so results are not guaranteed. The new drug may not be more effective than the existing drug everolimus, and side effects are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Adenoma, Islet Cell Neoplasm Metastasis neuroendocrine neoplasm pancreatic neuroendocrine tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTRA-PANCREATIC NEUROENDOCRINE TUMOR (EPNET) PANCREATIC NEUROENDOCRINE TUMOR (PNET)

Contacts and locations

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Study contacts

Contact

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Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Exelixis Clinical Site # 4
WITHDRAWN

San Juan, 00927, Puerto Rico
Exelixis Clinical Site #1
RECRUITING

Grand Rapids, Michigan, 49546, United States
Exelixis Clinical Site #10
RECRUITING

Dallas, Texas, 75264, United States
Exelixis Clinical Site #11
RECRUITING

Tampa, Florida, 33612, United States
Exelixis Clinical Site #12
RECRUITING

Santa Monica, California, 90404, United States
Exelixis Clinical Site #13
RECRUITING

Fairfax, Virginia, 22031, United States
Exelixis Clinical Site #14
RECRUITING

Albuquerque, New Mexico, 87131, United States
Exelixis Clinical Site #15
RECRUITING

Salt Lake City, Utah, 84112, United States
Exelixis Clinical Site #16
RECRUITING

Los Angeles, California, 90033, United States
Exelixis Clinical Site #17
RECRUITING

Chapel Hill, North Carolina, 27599, United States
Exelixis Clinical Site #18
RECRUITING

Beverly Hills, California, 90211, United States
Exelixis Clinical Site #19
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Exelixis Clinical Site #2
RECRUITING

San Juan, 00909, Puerto Rico
Exelixis Clinical Site #20
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Exelixis Clinical Site #21
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Exelixis Clinical Site #22
RECRUITING

London, England, SE5 9RS, United Kingdom
Exelixis Clinical Site #23
RECRUITING

Metairie, Louisiana, 70006, United States
Exelixis Clinical Site #24
RECRUITING

Knoxville, Tennessee, 37920, United States
Exelixis Clinical Site #25
RECRUITING

Omaha, Nebraska, 68198, United States
Exelixis Clinical Site #26
RECRUITING

Seoul, 06351, South Korea
Exelixis Clinical Site #27
RECRUITING

Portland, Oregon, 97210, United States
Exelixis Clinical Site #28
RECRUITING

Columbus, Ohio, 43221, United States
Exelixis Clinical Site #29
RECRUITING

Vallejo, California, 94589, United States
Exelixis Clinical Site #3
RECRUITING

Charlottesville, Virginia, 22903, United States
Exelixis Clinical Site #30
RECRUITING

Seoul, 02841, South Korea
Exelixis Clinical Site #31
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Exelixis Clinical Site #32
RECRUITING

Seoul, 03722, South Korea
Exelixis Clinical Site #33
RECRUITING

Sheffield, S10 2SJ, United Kingdom
Exelixis Clinical Site #34
RECRUITING

Seattle, Washington, 98109, United States
Exelixis Clinical Site #35
RECRUITING

Jacksonville, Florida, 32224, United States
Exelixis Clinical Site #36
RECRUITING

Phoenix, Arizona, 85054, United States
Exelixis Clinical Site #37
RECRUITING

Warsaw, 53-673, Poland
Exelixis Clinical Site #38
RECRUITING

Rochester, Minnesota, 55905, United States
Exelixis Clinical Site #39
RECRUITING

Cleveland, Ohio, 44106, United States
Exelixis Clinical Site #40
RECRUITING

Saint Leonards, New South Wales, 2065, Australia
Exelixis Clinical Site #41
RECRUITING

Seoul, 05505, South Korea
Exelixis Clinical Site #42
RECRUITING

Tucson, Arizona, 85724, United States
Exelixis Clinical Site #43
RECRUITING

Birmingham, Alabama, 35294, United States
Exelixis Clinical Site #44
RECRUITING

Madrid, 28046, Spain
Exelixis Clinical Site #45
RECRUITING

Katowice, 40-514, Poland
Exelixis Clinical Site #46
RECRUITING

Seoul, 03080, South Korea
Exelixis Clinical Site #47
RECRUITING

Detroit, Michigan, 48202, United States
Exelixis Clinical Site #48
RECRUITING

Graz, 8036, Austria
Exelixis Clinical Site #49
RECRUITING

Toronto, M4N3M5, Canada
Exelixis Clinical Site #5
RECRUITING

St Louis, Missouri, 63110, United States
Exelixis Clinical Site #50
RECRUITING

Liverpool, L7 8YA, United Kingdom
Exelixis Clinical Site #51
RECRUITING

Clayton, Victoria, 3168, Australia
Exelixis Clinical Site #52
RECRUITING

Tübingen, 72076, Germany
Exelixis Clinical Site #53
RECRUITING

Rochester, New York, 14642, United States
Exelixis Clinical Site #54
RECRUITING

Palo Alto, California, 94305, United States
Exelixis Clinical Site #55
RECRUITING

Herston, 4029, Australia
Exelixis Clinical Site #56
RECRUITING

Madrid, 28034, Spain
Exelixis Clinical Site #57
RECRUITING

Fargo, North Dakota, 58102, United States
Exelixis Clinical Site #59
RECRUITING

Buffalo, New York, 14263, United States
Exelixis Clinical Site #6
RECRUITING

Durham, North Carolina, 27710, United States
Exelixis Clinical Site #60
RECRUITING

Santander, 39008, Spain
Exelixis Clinical Site #61
RECRUITING

Ottawa, K1H8L6, Canada
Exelixis Clinical Site #62
RECRUITING

Seville, 41013, Spain
Exelixis Clinical Site #63
RECRUITING

Hong Kong, China
Exelixis Clinical Site #64
RECRUITING

Valencia, 46026, Spain
Exelixis Clinical Site #65
RECRUITING

Nashville, Tennessee, 37232, United States
Exelixis Clinical Site #66
RECRUITING

Murcia, 30008, Spain
Exelixis Clinical Site #67
RECRUITING

Woodville South, South Australia, 5011, Australia
Exelixis Clinical Site #68
RECRUITING

Clayton, Victoria, 3168, Australia
Exelixis Clinical Site #69
RECRUITING

Warsaw, Masovian Voivodeship, 02-034, Poland
Exelixis Clinical Site #7
RECRUITING

New York, New York, 10029, United States
Exelixis Clinical Site #70
RECRUITING

Roma, 00185, Italy
Exelixis Clinical Site #71
RECRUITING

Oxford, England, OX3 7LE, United Kingdom
Exelixis Clinical Site #72
RECRUITING

Gliwice, Ślaskie, 44-102, Poland
Exelixis Clinical Site #73
RECRUITING

Madrid, 28041, Spain
Exelixis Clinical Site #74
RECRUITING

Santiago de Compostela, A Coruña, 15706, Spain
Exelixis Clinical Site #75
RECRUITING

Würzburg, 97080, Germany
Exelixis Clinical Site #76
RECRUITING

Barcelona, 08029, Spain
Exelixis Clinical Site #77
RECRUITING

China, Hong Kong
Exelixis Clinical Site #78
RECRUITING

Naples, Naples, 80131, Italy
Exelixis Clinical Site #79
RECRUITING

Zaragoza, 50009, Spain
Exelixis Clinical Site #8
RECRUITING

Boston, Massachusetts, 02215, United States
Exelixis Clinical Site #80
RECRUITING

Oviedo, Principality of Asturias, 33011, Spain
Exelixis Clinical Site #9
RECRUITING

Lexington, Kentucky, 40536, United States
Exelixis Clinical Site 58
RECRUITING

Berlin, 13125, Germany