New daily pill aims to rival semaglutide for diabetes and weight loss

NCT ID NCT07662213

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This phase 3 study tests a new oral drug, elecoglipron, against the approved pill semaglutide in adults with type 2 diabetes who also have increased heart risk. The goal is to see which works better for lowering blood sugar and body weight over about a year. Participants take one of the two pills daily, and researchers track changes in HbA1c and weight.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Elecoglipron (oral drug)
What this could lead to: If successful, elecoglipron could offer a new once-daily pill option for managing blood sugar and weight in people with type 2 diabetes.
What could go wrong: This is a phase 3 trial, so results are not yet known. Elecoglipron may not prove better or safer than existing treatments like semaglutide.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 2 DIABETES MELLITUS

Contacts and locations

Locations

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Birmingham, Alabama, 35205, United States
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Mesa, Arizona, 85213, United States
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Phoenix, Arizona, 85016, United States
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Tempe, Arizona, 85281, United States
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Covina, California, 91723, United States
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Encinitas, California, 92024, United States
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Garden Grove, California, 92844, United States
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Loma Linda, California, 92350, United States
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Long Beach, California, 90807, United States
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Pomona, California, 91768, United States
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Sacramento, California, 95821, United States
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Bridgeport, Connecticut, 06606, United States
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Crystal River, Florida, 34429, United States
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Hollywood, Florida, 33021, United States
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Jacksonville, Florida, 32209, United States
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Leesburg, Florida, 34748, United States
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Orlando, Florida, 32806, United States
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Lilburn, Georgia, 30047, United States
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Idaho Falls, Idaho, 83404, United States
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Melrose Park, Illinois, 60160, United States
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Evansville, Indiana, 47710, United States
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Ames, Iowa, 50010, United States
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Wichita, Kansas, 67226, United States
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Bowling Green, Kentucky, 42101, United States
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Rockville, Maryland, 20852, United States
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Southfield, Michigan, 48076, United States
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Minneapolis, Minnesota, 55416, United States
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Jefferson City, Missouri, 65109, United States
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Kansas City, Missouri, 64114, United States
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Omaha, Nebraska, 68114, United States
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Henderson, Nevada, 89052, United States
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Las Vegas, Nevada, 89128, United States
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Albuquerque, New Mexico, 87112, United States
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Durham, North Carolina, 27701, United States
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Morehead City, North Carolina, 28557, United States
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Raleigh, North Carolina, 27612, United States
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Statesville, North Carolina, 28625, United States
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Wilmington, North Carolina, 28403, United States
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Columbus, Ohio, 43215, United States
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Yukon, Oklahoma, 73099, United States
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Feasterville-Trevose, Pennsylvania, 19053, United States
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Philadelphia, Pennsylvania, 19114, United States
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Myrtle Beach, South Carolina, 29572, United States
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North Charleston, South Carolina, 29405, United States
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Memphis, Tennessee, 38119, United States
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Morristown, Tennessee, 37813, United States
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Dallas, Texas, 75390, United States
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Houston, Texas, 77004, United States
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Houston, Texas, 77040, United States
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Houston, Texas, 77079, United States
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Katy, Texas, 77450, United States
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San Antonio, Texas, 78229, United States
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San Antonio, Texas, 78231, United States
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Sugar Land, Texas, 77478, United States
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Weslaco, Texas, 78596, United States
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Bountiful, Utah, 84010, United States
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Salt Lake City, Utah, 84124, United States
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Leesburg, Virginia, 20176, United States
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Norfolk, Virginia, 23502, United States
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Renton, Washington, 98057, United States
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Seattle, Washington, 98104, United States
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Seattle, Washington, 98105, United States
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Morgantown, West Virginia, 26505, United States
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Buenos Aires, C1425AGC, Argentina
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CABA, C1120AAC, Argentina
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Caba, C1128AAF, Argentina
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Ciudad de Buenos Aires, C1094AAD, Argentina
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Rosario, S2000CVD, Argentina
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San Nicolás, B2900DMH, Argentina
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San Vicente, 5006, Argentina
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Botany, 2019, Australia
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East Toowoomba, 4350, Australia
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Fitzroy, 3065, Australia
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Heidelberg Heights, 3081, Australia
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Kingswood, 2747, Australia
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Melbourne, 3004, Australia
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Parkville, 3050, Australia
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St Leonards, 2065, Australia
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Brasília, 71625-009, Brazil
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Campinas, 13060-904, Brazil
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Curitiba, 80030-480, Brazil
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Natal, 59020-035, Brazil
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Porto Alegre, 90630-165, Brazil
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São José dos Campos, 12243-280, Brazil
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São Paulo, 04012-180, Brazil
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Plovdiv, 4001, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1618, Bulgaria
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Sofia, 1700, Bulgaria
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Yambol, 8600, Bulgaria
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Vancouver, British Columbia, V5Y 3W2, Canada
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Guelph, Ontario, N1H 1B1, Canada
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Sarnia, Ontario, N7T 4X3, Canada
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Scarborough Village, Ontario, M1R 0B1, Canada
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Stouffville, Ontario, L4A1H2, Canada
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Toronto, Ontario, M4G3E8, Canada
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Toronto, Ontario, M6G 1M2, Canada
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Toronto, Ontario, M9V 4B4, Canada
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Montreal, Quebec, H4N 2W2, Canada
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Saint-Charles-Borromée, Quebec, J6E 2B4, Canada
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Changsha, 410013, China
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Changsha, 410015, China
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Hefei, 230000, China
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Hefei, 230601, China
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Huai'an, 223005, China
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Langfang, 065000, China
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Liangyugang, 222002, China
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Luoyang, 471009, China
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Nanjing, 2100008, China
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Nanyang, 473009, China
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Pinggu, 101200, China
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Pingxiang, 337055, China
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Shijiazhuang, 050000, China
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Tianjin, 300134, China
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Yueyang, 414000, China
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Bad Oeynhausen, 32545, Germany
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Berlin, 13597, Germany
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Chemnitz, 09116, Germany
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Damme, 49401, Germany
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Duisburg, 47051, Germany
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Elsterwerda, 04910, Germany
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Erlangen, 91054, Germany
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Essen, 45359, Germany
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Falkensee, 14612, Germany
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Gladbeck, 45968, Germany
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Hamburg, 21109, Germany
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Hamburg, 22607, Germany
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Leipzig, 04249, Germany
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Mannheim, 68167, Germany
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Münster, 48145, Germany
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Oldenburg, 23758, Germany
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Pirna, 01796, Germany
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Sankt Ingbert, 66386, Germany
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Wangen, 88239, Germany
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Budapest, 1036, Hungary
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Budapest, 1089, Hungary
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Budapest, 1132, Hungary
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Debrecen, 4032, Hungary
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Salgótarján, 3100, Hungary
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Szeged, 6725, Hungary
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Szolnok, 5000, Hungary
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Zalaegerszeg, 8900, Hungary
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Bari, 70124, Italy
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Bologna, 40138, Italy
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Chieti, 66100, Italy
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Milan, 20132, Italy
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Milan, 20138, Italy
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Modena, 41100, Italy
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Naples, 80138, Italy
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Roma, 00161, Italy
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Roma, 00168, Italy
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Asahikawa-shi, 070-8530, Japan
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Chūōku, 103-0002, Japan
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Kamakura-shi, 247-0056, Japan
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Koga-shi, 306-0232, Japan
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Mitaka-shi, 181-0013, Japan
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Mito, 310-0826, Japan
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Miyazaki, 880-0034, Japan
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Nagoya, 467-8602, Japan
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Nagoya, 468-0009, Japan
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Naka, 311-0113, Japan
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Naka, 311-0133, Japan
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Nishinomiya-shi, 663-8113, Japan
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Sapporo, 062-0007, Japan
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Takamatsu, 760-0018, Japan
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Bialystok, 15-897, Poland
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Krakow, 31-261, Poland
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Lodz, 90-338, Poland
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Lublin, 20-718, Poland
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Poznan, 60-354, Poland
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Radom, 26-600, Poland
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Warsaw, 00-124, Poland
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Warsaw, 02-507, Poland
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Daegu, 41404, South Korea
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Daejeon, 35015, South Korea
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Guri-si, 11923, South Korea
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Incheon, 21565, South Korea
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Seoul, 05278, South Korea
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Seoul, 06351, South Korea
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Changhua, 50006, Taiwan
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Kaohsiung City, 81362, Taiwan
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New Taipei City, 220, Taiwan
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Taichung, 40201, Taiwan
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Taichung, 40705, Taiwan
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Taichung, 433004, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10002, Taiwan
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Taoyuan, 333, Taiwan
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Yung Kang City, 71044, Taiwan
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Aberdeen, AB25 2ZN, United Kingdom
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Addlestone, KT15 2BH, United Kingdom
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Banbury, OX16 9AD, United Kingdom
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Bristol, BS34 5TF, United Kingdom
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Bristol, BS34 6BQ, United Kingdom
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Edinburgh, EH4 2XU, United Kingdom
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Hounslow, TW3 3LN, United Kingdom
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Penzance, TR18 3DX, United Kingdom
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Poole, BH16 5PW, United Kingdom
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Soham, CB7 5JD, United Kingdom
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Wansford, PE8 6PL, United Kingdom
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Yate, BS37 4AX, United Kingdom

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