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Scientists seek better way to measure Body's energy use

NCT ID NCT05398783

Knowledge-focused Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 20, 2026 · Updated 7 times

Summary

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo various tests, such as breath analysis, body scans, and blood samples. The goal is to develop more accurate ways to estimate metabolic rate, which could improve care for many diseases.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could lead to more accurate ways to measure metabolism, helping doctors tailor treatments for conditions like diabetes and obesity.
What could go wrong
This is an observational study, not a treatment trial. It will not directly test any therapy, and results may take years to influence medical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Jul 2031

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Local population, primary clinical, referred patients

Ages

2 to 99 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all the following criteria for their cohort: Cohort 1 - Healthy Volunteers * Male or female, aged \>=2 years * In good general health as evidenced by medical history Cohort 2 - Patients * Male or female, aged \>=2 years * Diagnosed with diseases thought to alter metabolism or body composition (such as weight loss or gain, diabetes, renal disease, obesity, cancer, etc.) or taking medications thought to alter metabolism or body composition. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: * Participants over 200 kg due to the weight limit of the equipment. * Presence of any implanted device that would interfere with measurements. * Any moderate to severe limitations in mobility that would impede participation * Hemoglobin less than 10 g/dL (in participants who would have blood drawn for research purposes). * Participants with dietary allergies, intolerances or eating patterns that would preclude them from consuming metabolic meals. * Participants unwilling or unable to give informed consent. * Participants with any other significant physical, medical, or psychiatric limitations, illness or conditions that may preclude them from completing the majority of the tests in this study per the discretion of the PI.

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Conditions

The condition(s) this trial relates to.

cancer chronic kidney disease chronic renal failure syndrome diabetes mellitus kidney disorder metabolic disease neoplasm obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer Chronic kidney disease Diabetes Metabolic disorders Normal physiology

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

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