NORMAL PHYSIOLOGY

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

This study uses transcranial magnetic stimulation (TMS) to see how it affects brain activity during learning and decision-making tasks. Researchers will test up to 600 healthy adults aged 18-45. Participants may undergo TMS, brain scans, and computer tasks to measure responses.

This study looks at how social factors like race and ethnicity influence how people express pain and how others assess it. Researchers will measure pain responses and brain activity in healthy volunteers, then test whether feedback can improve accuracy in judging others' pain. Th…

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This study aims to develop better brain imaging methods to understand how addiction affects the brain. Healthy adults aged 18 and older will undergo MRI scans, EEG, and other tests while performing simple tasks. The goal is to improve the reliability of these imaging techniques f…

This study aims to understand how the brain behaves during sleep by using fMRI and EEG to track brain activity while playing sounds. Healthy volunteers aged 18-34 will spend nights in an MRI scanner, wearing electrodes and headphones. The goal is to see how loud a sound needs to …

This study looks at how changing the amount and type of food you eat affects the energy your body uses to digest and process that food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days, eating only provided meals and spending multiple 24-hour periods in a seal…

This study collects blood and urine from 2,000 healthy adults aged 18 and older to build a repository for future laboratory research. Participants provide samples during a single 2-hour visit. The goal is to help scientists develop better tests and improve sample handling methods…

This study looks at whether overweight girls start puberty earlier than girls of normal weight. Researchers will use breast ultrasound and other tests to tell the difference between breast tissue and fatty tissue. The study involves 150 healthy girls ages 8-14 who have some breas…

This study uses magnetic resonance spectroscopy (MRS) to measure how the brain processes glucose into key chemical messengers like glutamate and GABA. Researchers aim to improve the accuracy and reliability of MRS technology. The study involves 200 healthy adults aged 18-65 and f…

This study aims to understand how healthy brains process what we see and hear. Researchers will use brain scans, eye tracking, and computer tasks to measure perception, memory, and attention. Up to 10,200 participants aged 13-65 with normal vision and hearing will take part onlin…

This study aims to develop and improve MRI scanning techniques for use in aging research. Healthy adults and individuals with certain conditions will undergo MRI scans, sometimes with contrast agents or while performing tasks. No treatment is given; the goal is to refine imaging …

This study aims to improve how MRI scans measure the body by collecting data from 200 healthy adults. Participants will have one or more MRI scans of the brain, liver, or other organs. The goal is to make these scans more consistent and useful for doctors, not to treat any diseas…

This study is developing and testing new tasks to measure how people learn and make decisions. Researchers will use smells, tastes, pictures, sounds, and even food to see how the brain responds. Some participants will also have an fMRI scan. The goal is to create reliable tests f…

This study looks at how thoughts and expectations change the way we feel pain. Healthy volunteers aged 18-50 will have brain scans and receive mild pain (heat or electric shocks) while researchers measure their heart rate, sweat, and brain activity. The goal is to understand pain…

This study aims to better understand pain by testing how people with and without pain disorders respond to various sensations like heat, cold, pressure, and sounds. Researchers will use questionnaires, physical exams, MRI scans, and sensory tests to gather detailed information. T…

This study aims to understand how the brain responds to magnetic stimulation when it is timed with natural brain waves. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to find ways to make brain stimulation more effective for im…

This study uses ultrasound, a safe imaging technique that uses sound waves, to get detailed pictures and measurements of nerves and muscles. Researchers aim to collect normal values from healthy adults and compare them with data from people who have neuromuscular disorders. The g…

This study tests a new type of sensor (OPM) that measures the tiny magnetic fields produced by brain activity. Researchers want to see if it can pinpoint brain activity more accurately than current technology. About 75 healthy adults aged 18-65 will do tasks like listening to sou…