NORMAL PHYSIOLOGY

This study aims to understand how healthy brains turn signals from our eyes and ears into what we see, hear, and think. Researchers will recruit up to 10,200 participants, many of whom will complete online tests, while others will have in-person sessions involving brain scans and…

This study aims to understand why people with major depression are twice as likely to use nicotine and have a harder time quitting. Researchers will use brain scans (MRI) to see how a single dose of nicotine affects brain function in non-smokers with and without depression. The g…

This study aims to improve MRI scan technology by collecting detailed images from healthy volunteers. Researchers want to make MRI measurements more reliable and accurate for future medical diagnosis. Healthy adults will undergo multiple MRI scans over time to help researchers un…

This study is testing a new, advanced type of brain scanner that measures the tiny magnetic fields produced by brain activity. Researchers are comparing this new scanner to an older model to see if it can map brain activity more precisely. Healthy adult volunteers will wear a spe…

This study aims to better understand how the healthy brain produces and uses its key chemical messengers. Researchers will use a special type of brain scan (MRS) to measure the natural production rates of glutamate and GABA in adults. The goal is to improve scanning techniques to…

This National Institutes of Health study aims to better understand how people experience pain. Researchers will enroll up to 10,000 people, both with and without pain conditions, to complete questionnaires, sensory tests, and brain scans. The goal is to gather detailed informatio…

This study aims to develop and improve MRI scanning techniques for future aging research. Researchers will test these methods on up to 1,000 healthy adults and people with aging-related conditions. Participants will undergo MRI scans, sometimes with special dyes or while performi…

This study aims to understand how psychological factors like expectations and emotions change how we feel pain. Researchers will recruit 500 healthy volunteers to undergo brain scans and simple tests involving mild, brief pain or other sensations. The goal is to map how the brain…

This study aims to improve how doctors measure nerve and muscle health using ultrasound. Researchers will scan the nerves and muscles of 150 people, including healthy volunteers and those with conditions like muscular dystrophy. The goal is to gather detailed pictures and measure…

This research aims to develop better brain scanning methods to study how addiction affects the brain. Healthy adult volunteers will undergo MRI scans while performing simple tasks to help researchers measure brain activity and structure. The goal is to create improved tools for f…

This study aims to understand if girls with higher body weight start puberty earlier than girls with normal weight. Researchers will use breast ultrasounds, blood tests, and other exams on 150 healthy girls aged 8-14 to get a clearer picture. The goal is to gather better informat…

This study aims to understand how the number of calories you eat changes the energy your body uses to digest and process food. Healthy volunteers will live in a clinic for about 35 days, eating controlled diets while researchers measure their metabolism in special rooms. The goal…

This study aims to create better formulas for measuring how the human body uses energy (metabolism). Researchers will compare 2000 healthy volunteers and people with conditions like diabetes or cancer. They will use detailed scans and breath tests during short hospital stays to u…

This research aims to understand why pain is assessed and treated differently across racial groups, contributing to healthcare disparities. The study involves healthy volunteers who will experience mild pain while researchers measure their responses, then have other participants …

This study aims to better understand what happens in the brain during sleep. Researchers will use MRI scans and EEG recordings on healthy young adults while they sleep overnight in a lab. Throughout the night, gentle sounds will be played to see how deeply the person is sleeping …

This study aims to understand how a non-invasive brain stimulation technique affects learning and decision-making in healthy people. Researchers will use a magnetic coil on the head and brain scans while participants do computer tasks. The goal is to gather basic knowledge that c…

This study aims to create and test a set of computer-based tasks to measure how people learn and make decisions. Researchers want to understand if these tasks can reliably measure thinking patterns, which may help explain why some people develop substance use disorders. Healthy v…

This study aims to understand how the brain responds to a non-invasive stimulation technique (TMS) to potentially improve treatments for arm and hand movement problems after a stroke. Researchers are testing if timing the stimulation to match a person's natural brainwave patterns…