NORMAL PHYSIOLOGY
Clinical trials for NORMAL PHYSIOLOGY explained in plain language.
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Brain scans probe the chemistry of opioid addiction
Knowledge-focused CompletedThis study aimed to understand how opioid addiction affects the brain's dopamine system, a key chemical messenger involved in reward and self-control. Researchers used brain scans (PET and MRI) and thinking tests to compare people with opioid use disorder—some on medication treat…
Matched conditions: NORMAL PHYSIOLOGY
Phase: EARLY_PHASE1 • Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA) • Aim: Knowledge-focused
Last updated Apr 02, 2026 03:41 UTC
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Could turning down the thermostat help fight obesity?
Knowledge-focused CompletedThis study aimed to understand how the human body burns calories at different room temperatures, focusing on a special type of fat called brown fat. Researchers enrolled 104 healthy adults to stay in a specialized room where temperatures were carefully controlled, from cool to wa…
Matched conditions: NORMAL PHYSIOLOGY
Phase: NA • Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:12 UTC
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Scientists map healthy Brain's wiring to create future disease reference
Knowledge-focused CompletedThis study aimed to measure and understand the normal patterns of connections between different brain regions in healthy adults. Researchers used MRI and PET scans on 112 healthy volunteers to see how reliable these brain connection measurements were when repeated. The goal was t…
Matched conditions: NORMAL PHYSIOLOGY
Phase: EARLY_PHASE1 • Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA) • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:11 UTC
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Can a good Night's sleep clean your brain?
Knowledge-focused CompletedThis study aimed to understand if sleep helps the brain clear away waste products, specifically a protein called amyloid-beta which is linked to Alzheimer's disease. Healthy adult participants stayed overnight twice—once sleeping normally and once staying awake—and had brain scan…
Matched conditions: NORMAL PHYSIOLOGY
Phase: EARLY_PHASE1 • Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA) • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:35 UTC
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Antibiotics' hidden impact: study probes effects beyond fighting infection
Knowledge-focused CompletedThis study aimed to understand how common antibiotics affect the body's natural systems in healthy people. Researchers gave 108 healthy adults either amoxicillin, azithromycin, or no drug, and then measured changes in their gut bacteria, immune system, and metabolism. The goal wa…
Matched conditions: NORMAL PHYSIOLOGY
Phase: PHASE1 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:20 UTC
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Scientists scan brain layers to unlock secret of skill memory
Knowledge-focused CompletedThis study aimed to understand how different layers of the brain's movement center help us learn and remember new physical skills, like typing a sequence. Researchers used advanced brain scans on 40 healthy adults while they practiced and rested during a simple typing task. The g…
Matched conditions: NORMAL PHYSIOLOGY
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:19 UTC
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Scientists map the brain to Fine-Tune future treatments
Knowledge-focused CompletedThis study aimed to improve non-invasive brain stimulation (NIBS) techniques, which have potential for treating brain disorders. Researchers worked with 83 healthy volunteers to test different stimulation settings and measure brain responses using MRI, EEG, and simple tasks. The …
Matched conditions: NORMAL PHYSIOLOGY
Phase: NA • Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated Mar 18, 2026 14:40 UTC
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Scientists scan thousands of brains to map mental illness
Knowledge-focused CompletedThis study aimed to better understand brain disorders like schizophrenia by comparing detailed brain scans of patients to those of healthy volunteers. Researchers used advanced MRI and MEG imaging technology to look for differences in brain structure, chemistry, and activity. The…
Matched conditions: NORMAL PHYSIOLOGY
Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated Mar 09, 2026 14:22 UTC