NORMAL PHYSIOLOGY
Clinical trials for NORMAL PHYSIOLOGY explained in plain language.
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Sleepless nights may leave brain waste behind
Knowledge-focused CompletedThis study looked at how sleep affects the brain's ability to clear out waste products, specifically amyloid-beta, which is linked to Alzheimer's disease. Twenty-two healthy adults stayed overnight in a clinic twice—once sleeping normally and once staying awake all night. Researc…
Matched conditions: NORMAL PHYSIOLOGY
Phase: EARLY_PHASE1 • Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA) • Aim: Knowledge-focused
Last updated May 17, 2026 05:29 UTC
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Brain scans reveal clues about schizophrenia in large imaging study
Knowledge-focused CompletedThis study used advanced brain scans (MRI and MEG) to compare the brains of over 3,000 people with schizophrenia and healthy volunteers. The goal was to find differences in brain structure, chemistry, and activity that could help explain schizophrenia. Participants did not receiv…
Matched conditions: NORMAL PHYSIOLOGY
Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated May 17, 2026 05:06 UTC
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Brain chemical clues: opioid use disorder and dopamine
Knowledge-focused CompletedThis study looked at how heavy opioid use changes dopamine, a brain chemical that affects pleasure and self-control. Researchers compared people with opioid use disorder (some on medication, some not) to healthy volunteers. They used brain scans and thinking tests to understand t…
Matched conditions: NORMAL PHYSIOLOGY
Phase: EARLY_PHASE1 • Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA) • Aim: Knowledge-focused
Last updated May 17, 2026 05:05 UTC
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Could a cooler room help you burn more calories?
Knowledge-focused CompletedThis study looked at how healthy adults burn calories when exposed to different temperatures, from cool to warm. Researchers wanted to learn if brown fat—a type of fat that burns energy to keep you warm—becomes active in adults when it's cold. The goal was to better understand wh…
Matched conditions: NORMAL PHYSIOLOGY
Phase: NA • Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated May 15, 2026 11:54 UTC
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Healthy volunteers help scientists test brain scan reliability
Knowledge-focused CompletedThis study looked at how consistent brain scans are when measuring connections between different brain regions. Researchers scanned 112 healthy adults twice on the same day using MRI and also used PET scans to measure brain activity. The goal was to understand normal brain functi…
Matched conditions: NORMAL PHYSIOLOGY
Phase: EARLY_PHASE1 • Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA) • Aim: Knowledge-focused
Last updated May 14, 2026 12:06 UTC
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Healthy volunteers needed to unlock brain stimulation secrets
Knowledge-focused CompletedThis study aims to improve non-invasive brain stimulation techniques by testing them on healthy adults aged 18 to 65. Researchers will use methods like magnetic stimulation and brain scans to see how the brain responds. The goal is to gather knowledge that could help diagnose or …
Matched conditions: NORMAL PHYSIOLOGY
Phase: NA • Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated May 06, 2026 16:01 UTC
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Antibiotics may do more than fight infection – new study reveals hidden effects
Knowledge-focused CompletedThis study looked at how two common antibiotics (amoxicillin and azithromycin) change the community of microbes living in healthy people, and whether those changes affect metabolism and the immune system. Over 100 healthy adults took antibiotics for a week or less, and researcher…
Matched conditions: NORMAL PHYSIOLOGY
Phase: PHASE1 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated May 05, 2026 11:55 UTC
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Scientists peer into Brain's learning layers
Knowledge-focused CompletedThis study aims to understand how different layers of the brain help us learn and remember new movement skills. Healthy participants will practice typing sequences with their left hand while having their brains scanned with MRI. Researchers want to see which specific brain layers…
Matched conditions: NORMAL PHYSIOLOGY
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Apr 16, 2026 13:01 UTC