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New pill plus chemo aims to tackle tough pancreatic cancer

NCT ID NCT07562152

Recruiting now Disease control Sponsor: Immuneering Corporation Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 11 times

Summary

This Phase 3 trial tests whether adding an experimental oral drug called atebimetinib to a modified chemotherapy regimen helps people with metastatic pancreatic cancer live longer. About 510 adults who have not had prior treatment will receive either the new combination or standard chemotherapy. The study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
atebimetinib (an experimental oral drug) combined with gemcitabine and nab-paclitaxel chemotherapy
What this could lead to
If successful, this could offer a new first-line treatment option that extends survival for people with metastatic pancreatic cancer.
What could go wrong
This is an early-stage Phase 3 trial, so results are not guaranteed. Adding a targeted drug to chemo may increase side effects without improving outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm Neoplasm Metastasis pancreatic adenocarcinoma pancreatic ductal adenocarcinoma pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC ADENOCARCINOMA PANCREATIC ADENOCARCINOMA METASTATIC PANCREATIC CANCER PANCREATIC CANCER METASTATIC PANCREATIC DUCTAL ADENOCARCINOMA PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) PDAC PDAC - PANCREATIC DUCTAL ADENOCARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Avera Cancer Institute Research

    RECRUITING

    Sioux Falls, South Dakota, 57105, United States

    Contact Email: •••••@•••••

  • Blue Ridge Cancer Care

    RECRUITING

    Blacksburg, Virginia, 24060, United States

  • Calvary Mater Newcastle

    RECRUITING

    Waratah, New South Wales, 2298, Australia

  • City of Hope

    RECRUITING

    Phoenix, Arizona, 85338, United States

    Contact Email: •••••@•••••

  • City of Hope

    RECRUITING

    Duarte, California, 91010, United States

  • City of Hope

    RECRUITING

    Chicago, Illinois, 60099, United States

  • Comprehensive Cancer Centers

    RECRUITING

    Las Vegas, Nevada, 89169, United States

  • Florida Cancer Specialists - East

    RECRUITING

    West Palm Beach, Florida, 33401, United States

    Contact Email: •••••@•••••

  • Florida Cancer Specialists - North

    RECRUITING

    St. Petersburg, Florida, 33701, United States

    Contact Email: •••••@•••••

  • Florida Cancer Specialists - South

    RECRUITING

    Sarasota, Florida, 34239, United States

    Contact Email: •••••@•••••

  • Genesiscare

    RECRUITING

    Waratah, New South Wales, 2298, Australia

  • Hematology Oncology Associates of the Treasure Coast

    RECRUITING

    Port Saint Lucie, Florida, 34952, United States

  • Icon Cancer Centre - Chermside

    RECRUITING

    Chermside, Queensland, 4032, Australia

    Contact Email: •••••@•••••

  • Illinois Cancer Specialists

    RECRUITING

    Arlington Heights, Illinois, 60005, United States

  • Maryland Oncology

    RECRUITING

    Columbia, Maryland, 21044, United States

  • Medical Oncology Hematology Consultants

    RECRUITING

    Newark, Delaware, 19713, United States

  • Missouri Cancer Associates

    RECRUITING

    Columbia, Missouri, 65201, United States

  • NYU Langone Health

    RECRUITING

    New York, New York, 10016, United States

  • Northwest Cancer Specialists

    RECRUITING

    Vancouver, Washington, 98684, United States

  • OSF Medical Center

    RECRUITING

    Peoria, Illinois, 61603, United States

  • Piedmont Healthcare

    RECRUITING

    Atlanta, Georgia, 30318, United States

  • Poudre Valley Health Care, Inc

    RECRUITING

    Fort Collins, Colorado, 80528, United States

  • Regional Cancer Care

    RECRUITING

    Belleville, New Jersey, 07109, United States

  • Rocky Mountain Cancer Centers

    RECRUITING

    Lone Tree, Colorado, 80124, United States

  • Sarah Cannon Research Institute

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Taylor Cancer Research Center

    RECRUITING

    Maumee, Ohio, 43537, United States

  • Texas Oncology - Austin

    RECRUITING

    Austin, Texas, 78705, United States

  • Texas Oncology - San Antonio

    RECRUITING

    San Antonio, Texas, 78240, United States

  • Texas Oncology - West Texas

    RECRUITING

    Abilene, Texas, 79606, United States

  • Texas Oncology Gulf Coast

    RECRUITING

    Webster, Texas, 77598, United States

  • Thomas Jefferson University

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

    Contact Email: •••••@•••••

  • University of Washington Fred Hutchinson Cancer Center

    RECRUITING

    Seattle, Washington, 98109, United States

    Contact Email: •••••@•••••

  • Virginia Cancer Specialists

    RECRUITING

    Fairfax, Virginia, 22031, United States

    Contact Email: •••••@•••••

  • West Cancer Center

    RECRUITING

    Germantown, Tennessee, 38138, United States

  • Willamette Valley Cancer Institute

    RECRUITING

    Eugene, Oregon, 97401, United States

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