New pill takes on Hard-to-Treat KRAS cancers

NCT ID NCT07629960

Recruiting now Disease control Sponsor: Blueprint Medicines Corporation Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This study tests an experimental drug called BLU-924 (SAR449336) in people with advanced pancreatic, lung, or colorectal cancers that have specific KRAS mutations. The drug is designed to block the cancer-driving KRAS protein. The trial will enroll about 265 participants to evaluate safety, dosing, and early signs of tumor shrinkage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BLU-924 (SAR449336), a pan-KRAS inhibitor tablet
What this could lead to: If successful, this could lead to a new targeted treatment option for people with advanced KRAS-mutant cancers, potentially shrinking tumors or slowing disease progression.
What could go wrong: This is an early-phase trial (Phase 1/2) with a small number of participants, so safety and effectiveness are not yet proven. The drug may cause side effects or fail to show meaningful benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal cancer colorectal neoplasm lung neoplasm Neoplasm Metastasis non-small cell lung carcinoma pancreatic adenocarcinoma pancreatic ductal adenocarcinoma pancreatic neoplasm rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR COLORECTAL NEOPLASMS NON-SMALL CELL LUNG CANCER PANCREATIC DUCTAL ADENOCARCINOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Florida Cancer Specialists & Research Institute - Sarasota
RECRUITING

Sarasota, Florida, 34242, United States
Next Oncology Virginia Cancer Specialist
RECRUITING

Fairfax, Virginia, 22031, United States

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