New diabetes drug aims to help when current meds fall short

NCT ID NCT06897475

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 7 times

Summary

This Phase 2 trial tests an experimental drug called LY3457263 in 240 adults with type 2 diabetes who still have high blood sugar despite taking stable doses of semaglutide or tirzepatide. Participants receive weekly injections of either the new drug or a placebo for about 9 months. The main goal is to see if LY3457263 lowers HbA1c more than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LY3457263 (an experimental injectable drug)
What this could lead to: If successful, this could offer a new add-on treatment option for people with type 2 diabetes who need better blood sugar control despite current medications.
What could go wrong: This is an early Phase 2 trial with only 240 participants, so results may not apply to everyone. The drug may not improve HbA1c significantly or could have side effects not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 2 DIABETES

Contacts and locations

Locations

4 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ
RECRUITING

Wroclaw, 50-981, Poland
Alliance for Multispecialty Research, LLC
RECRUITING

Norman, Oklahoma, 73069, United States
Balanced Life Health Care Solutions/SKYCRNG
RECRUITING

Lawrenceville, Georgia, 30046, United States
Bluewater Clinical Research Group Inc.
RECRUITING

Sarnia, N7T 4X3, Canada
Centricity Research Brampton Endocrinology
RECRUITING

Brampton, L6S 0C6, Canada
Centro de Endocrinologia Alcantara Gonzalez
RECRUITING

Bayamón, 00956, Puerto Rico
Centrum Badan Klinicznych PI-House sp. z o.o.
RECRUITING

Gdansk, 80-546, Poland
Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
RECRUITING

Lodz, 90-338, Poland
Clifton Medical Centre
RECRUITING

Rotherham, S65 1DA, United Kingdom
Clinical Research of Philadelphia
RECRUITING

Pennington, New Jersey, 08534, United States
Consano Clinical Research, LLC
RECRUITING

Shavano Park, Texas, 78231, United States
Diabetes Heart Research Centre
RECRUITING

Toronto, M6G 1M2, Canada
Eastside Research Associates
RECRUITING

Redmond, Washington, 98052, United States
Ecogene-21
RECRUITING

Chicoutimi, G7H 7K9, Canada
Ekamed
RECRUITING

Lublin, 20-718, Poland
Elite Clinical Trials
RECRUITING

Rexburg, Idaho, 83440, United States
Fadia El Boreky Medicine
RECRUITING

Waterloo, N2J 1C4, Canada
Frontier Clinical Research, LLC
RECRUITING

Scottdale, Pennsylvania, 15683, United States
FutureMeds - Birmingham
RECRUITING

Birmingham, B21 9RY, United Kingdom
FutureMeds - Liverpool
RECRUITING

Bromborough, CH62 6EE, United Kingdom
Futuremeds-Newcastle
RECRUITING

Newcastle, NE6 1SG, United Kingdom
G A Research Associates
RECRUITING

Moncton, E1G 1A7, Canada
Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut
COMPLETED

Leipzig, 04249, Germany
George Eliot Hospital
RECRUITING

Nuneaton, CV10 7DJ, United Kingdom
Helios Clinical Research - Phoenix
RECRUITING

Phoenix, Arizona, 85028, United States
InnoDiab Forschung Gmbh
COMPLETED

Essen, 45136, Germany
Institut für Diabetesforschung GmbH Münster
ACTIVE_NOT_RECRUITING

Münster, 48145, Germany
Investigators Research Group
RECRUITING

Brownsburg, Indiana, 46112, United States
Juno Research
RECRUITING

Houston, Texas, 77040, United States
Layton Medical Centre
RECRUITING

Blackpool, FY3 7EN, United Kingdom
Legeartis - Poradnie Specjalistyczne
RECRUITING

Bialystok, 15-404, Poland
Lucas Research, Inc.
RECRUITING

Morehead City, North Carolina, 28557, United States
Maple Leaf Research
RECRUITING

Toronto, M5G 1K2, Canada
Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
RECRUITING

Krakow, 31-261, Poland
Mgcendo Llc
RECRUITING

San Juan, 00921, Puerto Rico
NBR Polska
RECRUITING

Warsaw, 00-710, Poland
NYC Research INC
RECRUITING

Long Island City, New York, 11106, United States
Newquay Health Centre
RECRUITING

Newquay, TR7 1RU, United Kingdom
North Georgia Clinical Research
RECRUITING

Woodstock, Georgia, 30189, United States
Oviedo Medical Research
RECRUITING

Oviedo, Florida, 32765, United States
Physicians Research Associates
RECRUITING

Lawrenceville, Georgia, 30046, United States
Private Practice - Dr. Robert Witek
RECRUITING

Tarnów, 33-100, Poland
Providence Health Partners-Center for Clinical Research
RECRUITING

Dayton, Ohio, 45439, United States
RED-Institut GmbH
ACTIVE_NOT_RECRUITING

Oldenburg, 23758, Germany
Rame Group Practice
RECRUITING

Torpoint, PL11 2TB, United Kingdom
Renstar Medical Research
RECRUITING

Ocala, Florida, 34471, United States
Richmond University Medical Center
RECRUITING

Staten Island, New York, 10310, United States
Rophe Adult and Pediatric Medicine/SKYCRNG
RECRUITING

Union City, Georgia, 30291, United States
Shelby Clinical Research
RECRUITING

Shelby, North Carolina, 28150, United States
Southern Endocrinology Associates
RECRUITING

Mesquite, Texas, 75149, United States
Southgate Medical Group
RECRUITING

West Seneca, New York, 14224, United States
Southmead Hospital
RECRUITING

Bristol, BS10 5NB, United Kingdom
Szpital Czerniakowski
RECRUITING

Warsaw, 00-737, Poland
Texas Diabetes & Endocrinology, P.A.
RECRUITING

Round Rock, Texas, 78681, United States
Texas Valley Clinical Research
RECRUITING

Weslaco, Texas, 78596, United States
The Adam Practice
RECRUITING

Poole, BH16 5PW, United Kingdom
Velocity Clinical Research, Leipzig
RECRUITING

Leipzig, 04177, Germany
Viacar Recherche Clinique
RECRUITING

Longueuil, J4H 4B9, Canada
Winterberry Research Inc.
RECRUITING

Hamilton, L8J 0B6, Canada
Wolverine Clinical Trials
RECRUITING

Santa Ana, California, 92706, United States

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