New drug cocktail targets Hard-to-Treat tumors

NCT ID NCT05417594

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called AZD9574, taken alone or with other anti-cancer medicines, in about 695 people whose advanced solid tumors have grown despite prior treatment. The main goals are to check the drug's safety and find the right dose. Researchers will also look for early signs that the drug can shrink or slow tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

AZD9574 (an experimental drug taken by mouth, sometimes combined with other anti-cancer drugs)

What this could lead to

If it works, this could point toward a new treatment option for people with advanced solid cancers that have stopped responding to standard therapies.

What could go wrong

This is a very early (Phase 1/2a) trial with only 695 participants, so the drug may not prove effective or safe enough to move forward. Side effects are unknown and could be serious.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

astrocytoma (excluding glioblastoma) breast neoplasm cancer castration-resistant prostate carcinoma estrogen-receptor positive breast cancer exocrine pancreatic carcinoma fallopian tube cancer fallopian tube neoplasm glioma Her2-receptor negative breast cancer malignant pancreatic neoplasm ovarian cancer pancreatic neoplasm primary peritoneal carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID MALIGNANCIES

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Research Site
WITHDRAWN

La Jolla, California, 92093, United States
Research Site
RECRUITING

Los Angeles, California, 90095, United States
Research Site
RECRUITING

San Francisco, California, 94143, United States
Research Site
RECRUITING

Chicago, Illinois, 60611, United States
Research Site
RECRUITING

Boston, Massachusetts, 02215, United States
Research Site
RECRUITING

New York, New York, 10040, United States
Research Site
RECRUITING

New York, New York, 10065, United States
Research Site
COMPLETED

Portland, Oregon, 97239, United States
Research Site
RECRUITING

Houston, Texas, 77030, United States
Research Site
NOT_YET_RECRUITING

San Antonio, Texas, 78229, United States
Research Site
WITHDRAWN

Richmond, Virginia, 23298, United States
Research Site
RECRUITING

Darlinghurst, 2010, Australia
Research Site
RECRUITING

Melbourne, 3000, Australia
Research Site
RECRUITING

Randwick, 2031, Australia
Research Site
WITHDRAWN

Bayern, 80337, Germany
Research Site
WITHDRAWN

Berlin, 13353, Germany
Research Site
WITHDRAWN

Heidelberg, 69120, Germany
Research Site
WITHDRAWN

Mainz, 55131, Germany
Research Site
RECRUITING

Seoul, 03080, South Korea
Research Site
RECRUITING

Seoul, 03722, South Korea
Research Site
RECRUITING

Seoul, 06351, South Korea
Research Site
RECRUITING

A Coruña, 15006, Spain
Research Site
RECRUITING

Barcelona, 8035, Spain
Research Site
RECRUITING

Málaga, 29010, Spain
Research Site
RECRUITING

Pozuelo de Alarcón, 28223, Spain
Research Site
RECRUITING

Sant Cugat del Vallès, 08195, Spain
Research Site
RECRUITING

Seville, 41013, Spain
Research Site
RECRUITING

Lund, 22185, Sweden
Research Site
RECRUITING

Stockholm, 118 83, Sweden
Research Site
RECRUITING

Glasgow, Scotland, G12 0YN, United Kingdom
Research Site
RECRUITING

London, EC1M 6BQ, United Kingdom
Research Site
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom