Can a daily pill keep BRCA-Linked ovarian cancer at bay?

NCT ID NCT01874353

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This Phase 3 trial is investigating whether the drug olaparib can help women with a specific type of ovarian cancer stay in remission longer. The study includes women whose cancer has returned but responded well to platinum-based chemotherapy, and who carry a BRCA gene mutation. Participants take olaparib or a placebo daily to see if the drug delays cancer progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a drug called olaparib, taken as tablets
What this could lead to: If successful, this could offer a way to delay cancer progression in women with BRCA-mutated ovarian cancer, potentially extending the time before the disease worsens.
What could go wrong: This is a Phase 3 trial, but it is testing maintenance therapy, not a cure. Side effects from olaparib may occur, and not all patients may benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometrial endometrioid adenocarcinoma fallopian tube cancer ovarian cancer ovarian serous adenocarcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRCA MUTATED FOLLOWING COMPLETE OR PARTIAL RESPONSE TO PLATINUM BASED CHEMOTHERAPY PLATINUM SENSITIVE RELAPSED OVARIAN CANCER

Contacts and locations

Locations

1st Hospital of Jilin university

Changchun, China
69LYON, C Bérard, Onco

Lyon, France
69PIERREBE, CH Lyon Sud,

Pierre-Bénite, France
75PARIS, H Tenon, Onco

Paris, France
92STCLOUD, C Huguenin, Onco

Saint-Cloud, France
Addenbrooke's Hospital

Cambridge, United Kingdom
Arden Cancer Centre

Coventry, United Kingdom
Asan Medical Center

Seoul, South Korea
Aurora St Lukes Medical Center

Milwaukee, Wisconsin, United States
Azienda Ospedaliera Policlinico Di Modena

Modena, Italy
Barcelona,H.Clinic i Provincial,Oncología

Barcelona, Spain
Barcelona,H.de la Sta.Creu i S.Pau,Oncología

Barcelona, Spain
Beijing Cancer Hospital

Beijing, China
CAC François Baclesse

Caen, France
CHUM - Hopital Norte-Dame

Montreal, Quebec, Canada
CHUS Site Fleurimont

Sherbrooke, Quebec, Canada
Cancer Research UK and UCL Cancer Trials Centre

London, United Kingdom
Centre Alexis Vautrin

Vandœuvre-lès-Nancy, France
Centre Catherine de Sienne

Nantes, France
Centro Diagnóstico Barretos

Barretos, Brazil
Centro Regional Integrado de Oncologia

Fortaleza, Brazil
Centro de Novos Tratamentos Itajai

Itajaí, Brazil
Centro de Referencia da Saude da Mulher

São Paulo, Brazil
Centrum Onkologii Instytut im Marii Sklodowskiej-Curie

Warsaw, Poland
Chemotherapy Department, Russian Cancer Research Centre

Moscow, Russia
ChongQing Cancer Hospital

Chongqing, China
City Hospital Birmingham Cancer Trials Team

Birmingham, United Kingdom
Córdoba,H.Reina Sofía,Oncología

Córdoba, Spain
Dana Farber Cancer Institute

Boston, Massachusetts, United States
Edinburgh Cancer Research UK Centre

Edinburgh, United Kingdom
Erasmus Medisch Centrum

Rotterdam, Netherlands
First affiliated hospital college of XianJiaotong University

Xi'an, China
Friedrich-Alexander-Universität Erlangen-Nürnberg

Erlangen, Germany
Gangnam Severance Hospital

Seoul, South Korea
Gerona,H.Josep Trueta,Oncología

Girona, Spain
Greater Baltimore Medical Center

Baltimore, Maryland, United States
Gynecologic Cancer Center

Orlando, Florida, United States
Helios-Kliniken Berlin - Buch

Berlin, Germany
Henry Joyce Cancer Clinic

Nashville, Tennessee, United States
Hokkaido University Hospital

Sapporo, Japan
Hopital Européen Georges Pompidou

Paris, France
Hospital Araujo Jorge

Goiânia, Brazil
Hospital Provincial de Navarra

Pamplona, Spain
Hospital de Base São José do Rio Preto

São José do Rio Preto, Brazil
Hospital de Caridade de Ijuí

Ijuí, Brazil
Hospital de Clinicas de Porto Alegre

Porto Alegre, Brazil
Hotel-Dieu de Quebec

Québec, Quebec, Canada
Hunan Cancer Hospital

Changsha, China
Hyogo Cancer Center

Akashi-shi, Japan
Institut Bergonie

Bordeaux, France
Institut Claudius Regaud

Toulouse, France
Institut Curie Paris Et Saint Cloud

Paris, France
Institut Gustave Roussy

Villejuif, France
Instituto do Câncer de São Paulo

São Paulo, Brazil
Irmandade da Santa Casa de Misericordia de Porto Alagre

Porto Alegre, Brazil
Istituto Europeo di Oncologia

Milan, Italy
Istituto Nazionale Tumori Fondazione Pascale

Naples, Italy
Istituto Oncologico Veneto Irccs

Padova, Italy
Istituto Regina Elena-Polo Oncologico Ifo

Roma, Italy
JINAN, Qi Lu Hosp. of SD Univ.

Jinan, China
Jilin Provincial Cancer Hospital

Changchun, China
Johann-Wolfgang Goethe-Universität

Frankfurt, Germany
Johns Hopkins

Baltimore, Maryland, United States
Juravinski Cancer Centre

Hamilton, Ontario, Canada
Kindai University Hospital

Osakasayama-shi, Japan
Klinikum Essen-Mitte,Evang. Huyssens-Stiftung/Knapps gGmbH

Essen, Germany
Klinikum rechts der Isar der Technischen Universität

München, Germany
Leningrad Regional Oncology Dispensary

Saint Petersburg, Russia
London Health Sciences Centre

London, Ontario, Canada
MD Anderson at Cooper Cancer Center

Voorhees Township, New Jersey, United States
Maastricht Universitair Medisch Centrum

Maastricht, Netherlands
Madrid, H.C.S.Carlos,Oncología

Madrid, Spain
Madrid,H.12 de Octubre,Oncología

Madrid, Spain
Massachusetts General Hospital

Boston, Massachusetts, United States
Medizinische Hochschule Hannover

Hanover, Germany
Mercy Hospital for Women

Heidelberg, Australia
National Cancer Center Hospital

Chūōku, Japan
National Hospital Organization Kyushu Cancer Center

Fukuoka, Japan
National Hospital Organization Shikoku Cancer Center

Matsuyama, Japan
Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital

Amsterdam, Netherlands
Niepubliczny Zaklad Opieki Zdrowotnej Innowacyjna Medycyna

Grzepnica, Poland
Niigata University Medical and Dental Hospital

Niigata, Japan
North Shore University

Evanston, Illinois, United States
OSU JamesCare at Mill Run

Hilliard, Ohio, United States
Onkologie Ravensburg

Ravensburg, Germany
Palo Alto Foundation Medical Group

San Francisco, California, United States
Policlinico Universitario A. Gemelli

Roma, Italy
Prince of Wales Hospital

Randwick, Australia
Princess Margaret Cancer Centre

Toronto, Ontario, Canada
Rambam Health Care Campus

Haifa, Israel
Research Site

Guangzhou, 510060, China
Research Site

Shanghai, 200011, China
Royal Marsden Hospital

London, United Kingdom
Royal Marsden Hospital and Institute of Cancer Research

Sutton, United Kingdom
SPZOZ MSWiA z Warminsko-Mazurskim Centrum Onkologii

Olsztyn, Poland
Saitama Medical University International Medical Center

Hidaka-shi, Japan
Samsung Medical Center

Seoul, South Korea
Sapir Medical Centre

Kfar Saba, Israel
Seoul National University Hospital

Seoul, South Korea
Shanghai Cancer Hospital of Fudan University

Shanghai, China
Shizuoka Cancer Center

Sunto-gun, Japan
St.Petersburg City Oncology Dispensary, Dept. Gynecology

Saint Petersburg, Russia
Sunnybrook Health Sciences Center

Toronto, Ontario, Canada
Szpital Specjalistyczny im. Swietej Rodziny SPZOZ

Warsaw, Poland
Tel Hashomer

Ramat Gan, Israel
The Christie NHS Foundation Trust

Manchester, United Kingdom
The First Affiliated Hospital of Soochow University

Suzhou, China
The Hospital of Central Connecticut

New Britain, Connecticut, United States
The Royal Womens Hospital

Parkville, Australia
The Tumor Hospital affiliated to China Medical Science Insti

Beijing, China
The Tumour Hospital of Harbin Medical University

Harbin, China
U.Z. Gent

Ghent, Belgium
UZ Leuven Gasthuisberg

Leuven, Belgium
Universitair Medisch Centrum St. Radboud

Nijmegen, Netherlands
University of Alabama at Birmingham

Birmingham, Alabama, United States
University of Colorado

Aurora, Colorado, United States
Universitätsklinikum Rostock

Rostock, Germany
Universitätsklinikum Schleswig-Holstein

Lübeck, Germany
Valencia, IVO, Oncología

Valencia, Spain
Valencia,H.C.U.Valencia,Oncología

Valencia, Spain
West China Hospital Affiliated to Sichuan University

Chengdu, China
Winthrop Gynecologic Oncology Associates

Mineola, New York, United States
Wojewódzki Szpital Specjalistyczny w Olsztynie

Olsztyn, Poland
Women's Hospital, Zhejaing University School of Medicine

Hangzhou, China
Womens Cancer Care Associates

Albany, New York, United States
Zhejiang Cancer Hospital, Huangzhou

Huangzhou, China

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