New diabetes pill icovamenib enters Mid-Stage trial

NCT ID NCT07502495

Recruiting now Disease control Sponsor: Biomea Fusion Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests whether a new drug called icovamenib can help people with type 2 diabetes who still have high blood sugar despite taking other medications. About 60 adults aged 18 to 70 will receive either icovamenib or a placebo daily for 12 weeks. The main goal is to see if icovamenib lowers HbA1c, a key blood sugar measure, better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: icovamenib
What this could lead to: If it works, this could offer a new daily pill option for people with type 2 diabetes to better control their blood sugar.
What could go wrong: This is an early Phase 2 trial with only 60 participants, so results may not apply to everyone. The drug may not work better than placebo or could have side effects.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYPE 2 DIABETES

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Ark Clinical Research
RECRUITING

Long Beach, California, 90815, United States
Catalina Research Institute, LLC
RECRUITING

Montclair, California, 91763, United States
Central Research Associates, LLC dba Flourish Research
RECRUITING

Birmingham, Alabama, 35205, United States
Clinical Site Partners, LLC dba Flourish Research
RECRUITING

Winter Park, Florida, 32789, United States
David Kavtaradze MD, Inc
RECRUITING

Cordele, Georgia, 31015, United States
Diabetes and Endocrinology Associates of Stark County
RECRUITING

Canton, Ohio, 44718, United States
Elligo Health Research, Inc.
RECRUITING

Austin, Texas, 78704, United States
Epic Clinical Research
RECRUITING

Lewisville, Texas, 75057, United States
Excel Clinical Research
RECRUITING

Las Vegas, Nevada, 89109, United States
Hope Clinical Research
RECRUITING

Canoga Park, California, 91303, United States
Manassas Clinical Research Center
RECRUITING

Manassas, Virginia, 20110, United States
Panax Clinical Research
RECRUITING

Miami Lakes, Florida, 33014, United States
Paradigm Clinical Research Centers, LLC
RECRUITING

San Diego, California, 92108, United States
Southwest General Healthcare Center
RECRUITING

Fort Myers, Florida, 33907, United States
Synergy Groups Medical
RECRUITING

Houston, Texas, 77061, United States
Zenos Clinical Research
RECRUITING

Dallas, Texas, 75230, United States

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