Engineered immune cells take aim at Hard-to-Treat cancers

NCT ID NCT05877599

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 4 times

Summary

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 is made from a patient's own immune cells, which are genetically modified to better recognize and attack cancer cells. The main goals are to check the treatment's safety and see if it can shrink tumors.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia breast cancer breast neoplasm cancer colorectal adenocarcinoma colorectal carcinoma colorectal neoplasm head and neck squamous cell carcinoma myelodysplastic syndrome myeloid neoplasm neoplasm non-small cell lung carcinoma ovarian cancer pancreatic adenocarcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER COLORECTAL CARCINOMA HEAD AND NECK SQUAMOUS CELL CARCINOMA MYELOID NEOPLASMS (AML/MDS) NON-SMALL CELL LUNG CANCER OTHER SOLID TUMORS OVARIAN CANCER PANCREATIC ADENOCARCINOMA

Contacts and locations

Locations

Research Site
RECRUITING

Gilbert, Arizona, 85234, United States
Research Site
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Duarte, California, 91010, United States
Research Site
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Newport Beach, California, 92663, United States
Research Site
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Santa Monica, California, 90404, United States
Research Site
RECRUITING

Jacksonville, Florida, 32224, United States
Research Site
WITHDRAWN

Miami, Florida, 33136, United States
Research Site
WITHDRAWN

Tampa, Florida, 33612, United States
Research Site
RECRUITING

Boston, Massachusetts, 02115, United States
Research Site
RECRUITING

New Brunswick, New Jersey, 08901, United States
Research Site
RECRUITING

New York, New York, 10065, United States
Research Site
WITHDRAWN

Charlotte, North Carolina, 28204, United States
Research Site
WITHDRAWN

Winston-Salem, North Carolina, 27103, United States
Research Site
RECRUITING

Portland, Oregon, 97213, United States
Research Site
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Research Site
RECRUITING

Nashville, Tennessee, 37203, United States
Research Site
RECRUITING

Houston, Texas, 77030, United States
Research Site
RECRUITING

Round Rock, Texas, 78665, United States
Research Site
RECRUITING

Milwaukee, Wisconsin, 53226, United States

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