Massive study seeks to unlock how your surroundings and DNA shape disease risk

NCT ID NCT00341237

Recruiting now Knowledge-focused Sponsor: National Institute of Environmental Health Sciences (NIEHS) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 06, 2026 · Updated 12 times

Summary

This study looks at how your genes and your environment—like what you eat, breathe, and experience—work together to influence common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires, genetic data, and other information from 25,000 adults. The goal is to better understand why some people get sick while others don't, which could lead to new ways to prevent disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help identify which environmental factors interact with genes to cause or protect against common diseases, pointing toward new prevention strategies.
What could go wrong: This is an observational study, not a treatment trial. It may not directly lead to any new therapies, and findings may need confirmation in larger, more diverse populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma diabetes mellitus heart disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA DIABETES HEART DISEASE

Contacts and locations

Locations

NIEHS Clinical Research Unit (CRU)
RECRUITING

Research Triangle Park, North Carolina, 27713, United States
University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27599-7030, United States

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