Can tailored fluid dosing tame pancreatitis?

NCT ID NCT07756476

Recruiting now Disease control Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial tests whether giving fluids based on real-time changes in stroke volume—a measure of how much blood the heart pumps—can improve outcomes in people with moderate to severe acute pancreatitis. Standard care uses a fixed weight-based amount, which can sometimes lead to fluid overload. The study will compare the two approaches in 80 adults, tracking whether the personalized method reduces systemic inflammation (SIRS) at 48 hours and lowers complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lactated Ringer's solution, dosed based on changes in stroke volume
What this could lead to: If successful, this could lead to a more personalized fluid resuscitation strategy that reduces complications and improves recovery in acute pancreatitis.
What could go wrong: This is a small, early-stage trial, and the approach may not prove better than standard weight-based dosing. There are risks of fluid overload or adverse events in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACUTE PANCREATITIS (AP) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute pancreatitis pancreatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PANCREATITIS (AP)

Contacts and locations

Locations

Ohio State University
ACTIVE_NOT_RECRUITING

Columbus, Ohio, 43210, United States
University of Southern California
RECRUITING

Los Angeles, California, 90033, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.