Could a back injection ease the need for life support in pancreatitis?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion Criteria: 1. Age 18 to 75 years, inclusive. 2. Diagnosis of acute pancreatitis based on at least two of the following three criteria: typical acute upper abdominal pain; serum amylase and/or lipase at least three times the upper limit of normal; or imaging findings consistent with acute pancreatitis. 3. Time from symptom onset to randomization of 72 hours or less. 4. Early respiratory, cardiovascular, or renal organ dysfunction, defined as a SOFA-2 subscore of 2 or greater in at least one of these three organ systems, requiring ICU admission for continuous monitoring and treatment. The SOFA-2 score will be calculated using the worst available values during the 24 hours before randomization; for participants admitted to the ICU for less than 24 hours, values available since ICU admission will be used. The organ dysfunction must be newly developed or clearly worsened from the participant's previous stable baseline. 5. Written informed consent provided by the participant or legally authorized representative. Exclusion Criteria: 1. Pregnancy or lactation. 2. Chronic pancreatitis or acute pancreatitis associated with a pancreatic tumor. 3. Prior retroperitoneal drainage, endoscopic drainage, surgical necrosectomy, or other invasive intervention before randomization that may substantially alter the natural course of the disease. 4. Invasive mechanical ventilation before randomization. 5. Any contraindication to thoracic epidural analgesia, including allergy to local anesthetics; infection at the puncture site; epidural abscess or central nervous system infection; severe spinal deformity or prior spinal surgery that prevents catheterization; intracranial hypertension or severe central nervous system disease; uncorrected coagulation disorder; or anticoagulant or antiplatelet therapy that does not meet neuraxial safety requirements. 6. Uncorrected shock or persistent hemodynamic instability despite adequate fluid resuscitation and vasoactive drug support. 7. End-stage renal disease requiring maintenance dialysis before randomization. 8. Participation in another interventional clinical study within the previous 3 months. 9. Any other condition that, in the investigator's judgment, makes the participant unsuitable for enrollment.