New drug combo aims to protect kidneys in diabetes

NCT ID NCT07271186

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 4 times

Summary

This Phase 2 trial tests two experimental drugs, ALN-ANG3 and evinacumab, in 270 people with diabetic kidney disease. The drugs block a protein called ANGPTL3 to lower blood fats. Researchers will measure changes in urine protein and kidney function over time to see if the drugs are safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ALN-ANG3 and evinacumab (two experimental drugs that block a protein called ANGPTL3 to lower fats in the blood)
What this could lead to: If successful, this could point toward a new treatment option to slow kidney damage in people with diabetic kidney disease.
What could go wrong: This is a Phase 2 trial with only 270 participants, so results are still early. The drugs may not improve kidney function or could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic renal failure syndrome diabetic kidney disease type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC KIDNEY DISEASE (DKD)

Contacts and locations

Locations

AGA Clinical Trials
RECRUITING

Hialeah, Florida, 33012, United States
AME Clinical Research
RECRUITING

Huntington Beach, California, 92647, United States
Amicis Research Center
RECRUITING

Northridge, California, 91325, United States
Amicis Research Center
RECRUITING

Santa Clarita, California, 91355, United States
Amicis Research Center
RECRUITING

Valencia, California, 91355, United States
Apogee Clinical Research, LLC
RECRUITING

Huntsville, Alabama, 35801, United States
Applied Research Center of Arkansas
RECRUITING

Little Rock, Arkansas, 72205, United States
Arlington Nephrology, PLLC.
RECRUITING

Arlington, Texas, 76015, United States
Bolanos Clinical Research
RECRUITING

Pembroke Pines, Florida, 33026, United States
Brookview Hills Research Associates, LLC
RECRUITING

Winston-Salem, North Carolina, 27103, United States
CDC Research Institute
RECRUITING

Port Saint Lucie, Florida, 34952, United States
CHEAR Center LLC
RECRUITING

The Bronx, New York, 10455, United States
Central Coast Nephrology
RECRUITING

Salinas, California, 93901, United States
Central Florida Kidney Specialists Oakwater
RECRUITING

Orlando, Florida, 32806, United States
Clinical Advancement Center
RECRUITING

San Antonio, Texas, 78212, United States
Clinical Research Consultants, LLC
RECRUITING

Kansas City, Missouri, 64111, United States
Clinical Trial Network, LLC
RECRUITING

Houston, Texas, 77074, United States
Convenient Medical Center
RECRUITING

Hialeah, Florida, 33013, United States
D&H Doral Research Center
RECRUITING

Doral, Florida, 33122, United States
D&H National Research Centers, Inc
RECRUITING

Miami, Florida, 33155, United States
D&H Pompano Research Center
RECRUITING

Margate, Florida, 33063, United States
D&H Tamarac Research Center
RECRUITING

Tamarac, Florida, 33321, United States
DaVita Clinical Research
RECRUITING

Las Vegas, Nevada, 89107, United States
Eastern Nephrology Associates - Greenville West
RECRUITING

Greenville, North Carolina, 27834, United States
Eastern Nephrology Associates - New Bern
RECRUITING

New Bern, North Carolina, 28562, United States
El Paso Kidney Specialists-Davita Clinical Research
RECRUITING

El Paso, Texas, 79902, United States
Elixia Hollywood
RECRUITING

Hollywood, Florida, 33024, United States
Elixia MNA
RECRUITING

City of Saint Peters, Missouri, 63376, United States
Elixia Michigan Kidney Consultants
RECRUITING

Pontiac, Michigan, 48341, United States
Epic Medical Research LLC
RECRUITING

DeSoto, Texas, 75115, United States
FOMAT - Vista del Mar Medical Group
RECRUITING

Oxnard, California, 93036, United States
Gulf Coast Clinical Research
RECRUITING

Katy, Texas, 77450, United States
IMA Clinical Research
RECRUITING

Monroe, Louisiana, 71201, United States
Innovia Research Center
RECRUITING

Miramar, Florida, 33027, United States
Juno Research, LLC
RECRUITING

Houston, Texas, 77040, United States
LCC Medical Research Institute
RECRUITING

Miami, Florida, 33126, United States
M3 Wake Research Dallas - Internal Medicine
RECRUITING

Dallas, Texas, 75224, United States
Metabolic Research Institute
RECRUITING

West Palm Beach, Florida, 33401, United States
National Institute of Clinical Research, Inc.
RECRUITING

Victorville, California, 92392, United States
North America Research Institute
RECRUITING

San Dimas, California, 91773, United States
Northeast Clinical Research Center
RECRUITING

Bethlehem, Pennsylvania, 18017, United States
Ocean Blue Medical Research Center - Internal Medicine
RECRUITING

Miami Springs, Florida, 33166, United States
Privia Medical Group of Georgia, LLC
RECRUITING

Savannah, Georgia, 31406, United States
Progressive Medical Research
RECRUITING

Port Orange, Florida, 32127, United States
Prolato Research LLC
RECRUITING

Houston, Texas, 77054, United States
R & H Clinical Research, Inc.
RECRUITING

Katy, Texas, 77450, United States
Regenerate Primary Medical Research, LLC
RECRUITING

Miami, Florida, 33155, United States
Research by Design, LLC - Internal Medicine
RECRUITING

Chicago, Illinois, 60643, United States
Revival Research Institute, LLC
RECRUITING

Dallas, Texas, 75231, United States
Southeast Renal Research Institute
RECRUITING

Chattanooga, Tennessee, 37404, United States
Suburban Research Associates
RECRUITING

West Chester, Pennsylvania, 19380, United States
Sunbeam Clinical Research
RECRUITING

McKinney, Texas, 75069, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Texas Health - San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Valiance Clinical Research
RECRUITING

Tarzana, California, 91356, United States
Velocity Clinical Research
RECRUITING

Binghamton, New York, 13905, United States
Yale University
RECRUITING

New Haven, Connecticut, 06510, United States

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