Can a diabetes drug boost weight-loss surgery outcomes?
NCT ID NCT07732738
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This study investigates whether combining bariatric surgery with a GLP-1 receptor agonist (semaglutide) leads to greater and more sustained weight loss than surgery alone in people with obesity. Researchers will follow 400 participants across multiple centers in China for up to two years, measuring weight, metabolic health, and safety. The goal is to see if the combination can prevent the weight regain that sometimes occurs after surgery alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of laparoscopic sleeve gastrectomy and semaglutide injections
- What this could lead to
- If successful, this combination could offer a more effective long-term weight-loss strategy for people with obesity, reducing weight regain after surgery.
- What could go wrong
- This is an early-stage study without a control group receiving only surgery, so it is unclear how much benefit comes from the drug versus the procedure itself. Side effects from semaglutide, such as nausea or gastrointestinal issues, are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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China-Japan Friendship Hospital
RECRUITINGBeijing, China
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Sinopharm Tongmei General Hospital
RECRUITINGDatong, Shanxi, China
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The First People Hospital Of Yunnan Province
RECRUITINGKunming, Yunnan, China
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The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology
RECRUITINGBaotou, Inner Mongolia, China
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The Second Hospital, Cheeloo College of Medicine, Shandong University
RECRUITINGJinan, Shandong, China
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Xingtai Ninth Hospital
RECRUITINGXingtai, Hebei, China
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Zhengzhou Central Hospita
RECRUITINGZhengzhou, Henan, China
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