Second chance: repeat islet transplants tested for type 1 diabetes

NCT ID NCT07666789

Recruiting now Disease control Sponsor: University Hospital, Montpellier Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a second islet transplant can safely improve blood sugar control in adults with type 1 diabetes whose first transplant stopped working. Researchers will follow 20 patients for up to 5 years, checking graft function, insulin use, and severe low blood sugar events. The goal is to understand if re-transplantation is worth the risks, including possible immune reactions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: islet cells (from donor pancreas)
What this could lead to: If successful, this could show that a second islet transplant helps people with type 1 diabetes regain blood sugar control after the first transplant stops working.
What could go wrong: This is a small, retrospective study (20 people) that looks back at past data, not a controlled trial. Repeated transplants may increase immune reactions that could harm the new graft.

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ISLETS OF LANGERHANS TRANSPLANTATION TYPE 1 DIABETES (T1D)

Contacts and locations

Locations

Montpellier University Hospital
RECRUITING

Montpellier, 34000, France

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