New drug AZD4248 tested for kidney disease in first human trials

NCT ID NCT07024823

Recruiting now Knowledge-focused Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This early-stage study tests the safety of a new drug called AZD4248 in healthy volunteers and people with chronic kidney disease and type 2 diabetes. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. The study also looks at whether people can reliably measure their kidney function at home using a simple test.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AZD4248
What this could lead to: If successful, this could pave the way for a new treatment option for chronic kidney disease in people with type 2 diabetes.
What could go wrong: This is an early Phase 1 trial focused on safety, so it's too soon to know if AZD4248 will work. The drug may cause side effects or prove ineffective in later studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome diabetic kidney disease type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE

Contacts and locations

Locations

Research Site
RECRUITING

Glendale, California, 91206, United States
Research Site
RECRUITING

Chicago, Illinois, 60643, United States
Research Site
ACTIVE_NOT_RECRUITING

Ann Arbor, Michigan, 48109, United States
Research Site
RECRUITING

Saint Paul, Minnesota, 55114, United States
Research Site
RECRUITING

San Antonio, Texas, 78215, United States

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